Description | Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MEAPPVTMMPVSGGTINMMEYLLQGSVLDQCLESLLHRLRGLCDNMEPETFLDHEMVFLLKGQQASPFVLRARRSMDKSGMPWHLRYLGQPEIGDKSRHALVRNCVDIATSDNLTDFLVEMGFRMDHEFVAKGHVFRKGIMKIMVYKIFRILMPGNTDSIEPLSLSYLVELNVVAPAGQDIVSDDMRNFAEQLKPLVHLEKIDPKRLM |
Length | 208 |
Position | Head |
Organism | Amazona aestiva (Blue-fronted Amazon parrot) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Psittaciformes> Psittacidae> Amazona. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.084 |
Instability index | 44.45 |
Isoelectric point | 5.97 |
Molecular weight | 23705.56 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP05530 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 132.32| 39| 63| 19| 58| 1 --------------------------------------------------------------------------- 19- 58 (65.08/50.49) MEYLLQGSVLDQCLESLLHRLRGLCDNMEPETFLdHEMVF 85- 123 (67.24/47.09) LRYLGQPEIGDKSRHALVRNCVDIATSDNLTDFL.VEMGF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FVLRARR 2) MPWHLRYLGQ | 68 81 | 74 90 |
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