<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05522

Description Uncharacterized protein
SequenceMAAFGVLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINNWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKYSGEFVQSAYLSRRLAYFCTRRLAMQLDGAGGHPPHILSAQTGNALPSTPTPQPAAGNPPPSPFSDLLLCPQHRPVVYGLSCILQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGLGPTKDSHEISPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSISSGSLSAASAPVFQDVLMQFLDTQAPMLTDPGKENEKVEFFNLVLLFCELIRHDVFSHNIYMCTLISRGDLAMDSHGPRPPSPFDDPAEEHDRKETEGNSGIKLEDTGLSEPIDIDHNSSMLFDDMEKTDFSMFSPPMHCESKASPSPEKPDPEKEAKPLLKDKSVEGMLASLYDQPRHIQYATHFPIPQEESCSHECNQRLVVLFGVGKXRDDARHTIKKITKDILKVLNRKSTAETGGEEGQKRKKSKPEAFPTAEDIFAKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPEFMIDTIENPSAHNFTYTNLGKSLNENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHLGGVDDLMDDELGARKSGSRVVTVETASLDIYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTTNNEMNSLLENIAKATIEVFQQSAETSSASCAGNGVNNISSSASATPASNKSKPILSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKXRDRQKQKSELFTTVLDMLSVLINGTLAADMSSISQGSMEXNKRAYMNLVKKLRKELGDRQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRKVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVALEPEKKAAEPAKSDKTSSNPATSTEERKKKQSKTKKRNQSASKTEDFVLGPSRGVSYGVGMPTDLLHHQPGSTMSRXAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPXSGVLPPGMGSMMGIDPSYKPAVYRQQPPVSQGQILRQQLQAKLGYTSYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLGNTQRFPHQSIQQTPMMSGMNHLGPQGVPSGIRPSQILPDQQQQQYLRQQQQQQQQMLRFQRQGLQQTQQQQQTAALVRQLQQQLSNTQTQQNNNPFGRY
Length1814
PositionKinase
OrganismAmazona aestiva (Blue-fronted Amazon parrot)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Psittaciformes> Psittacidae> Amazona.
Aromaticity0.07
Grand average of hydropathy-0.465
Instability index51.57
Isoelectric point7.52
Molecular weight201287.34
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05522
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.25|      13|      15|    1757|    1770|       1
---------------------------------------------------------------------------
 1767- 1783 (20.17/ 9.78)	QQQQmlrfQRQGL.QQTQ
 1784- 1797 (16.09/12.18)	QQQQ....TAALVrQLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.62|      26|      27|    1672|    1697|       2
---------------------------------------------------------------------------
 1672- 1697 (48.59/24.01)	YSGQPYQNSH..PSS.NPALVD....PVRQMQQ
 1702- 1727 (32.96/13.73)	YVHQQA......PGY.GHTLGNtqrfPHQSIQQ
 1731- 1759 (37.07/16.43)	MSGMNHLGPQgvPSGiRPSQIL....PDQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.01|      15|      15|    1219|    1233|       3
---------------------------------------------------------------------------
 1219- 1233 (27.01/18.43)	SASCAGNGVNNISSS
 1235- 1249 (26.00/17.41)	SATPASNKSKPILSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      16|     680|     694|       4
---------------------------------------------------------------------------
  680-  694 (26.85/16.82)	LEQITSFALG.MSYHL
  696-  711 (23.14/13.46)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.73|      15|      16|    1046|    1060|       5
---------------------------------------------------------------------------
 1046- 1060 (24.84/16.35)	FAVLKAVFVLGDAEL
 1065- 1079 (27.89/19.31)	FSHLGGVDDLMDDEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.54|      10|      16|    1457|    1467|       6
---------------------------------------------------------------------------
 1457- 1467 (16.54/12.37)	KPkPRSYYLEP
 1476- 1485 (20.00/10.07)	EP.PTPVALEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.29|      21|      26|    1116|    1141|       7
---------------------------------------------------------------------------
 1116- 1141 (30.77/26.78)	RCLKSLCEDSNDLQDPvlsstQAQRL
 1145- 1165 (38.53/21.87)	ICYPHRLLDNEEGENP.....QRQRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.12|      23|      27|     985|    1009|       8
---------------------------------------------------------------------------
  985- 1009 (38.79/28.45)	CSEQDSEP..GARLTCRilLHLFKTPQ
 1013- 1037 (38.33/21.95)	CQQDGNKPtvGIRSSCD..RHLLAASQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.54|      14|      17|    1390|    1406|       9
---------------------------------------------------------------------------
 1390- 1406 (16.85/18.90)	KIAGFDsIFkkEGLQVS
 1410- 1423 (28.68/17.05)	KISPWD.LF..EGLKHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.48|      10|      25|     204|     213|      11
---------------------------------------------------------------------------
  204-  213 (20.46/ 7.35)	AGGHPPHILS
  230-  239 (23.02/ 9.14)	AGNPPPSPFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.71|      16|      27|    1620|    1635|      12
---------------------------------------------------------------------------
 1620- 1635 (30.94/14.77)	SYKPAVYRQQPPVSQG
 1650- 1665 (27.78/12.48)	SYVSHIGLQQHPSQSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.00|      23|     217|     311|     363|      13
---------------------------------------------------------------------------
  337-  360 (37.54/66.81)	HEiSPDDDAVVALLCEWAVSYKRS
  892-  914 (43.46/10.03)	HH.DPDRVNDIAILCAELTGYCKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.82|       9|      17|     854|     863|      14
---------------------------------------------------------------------------
  854-  863 (13.42/ 9.64)	ENPsAHNFTY
  872-  880 (16.39/ 6.77)	ENP.ANRYSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.17|      12|      26|    1565|    1576|      19
---------------------------------------------------------------------------
 1565- 1576 (24.17/15.51)	PVGLYAQNQP.....LP
 1592- 1608 (17.01/ 8.25)	PLGKLVQSRPpxsgvLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.64|      12|      26|     148|     159|      20
---------------------------------------------------------------------------
  148-  159 (22.56/18.59)	KYTVPVMRAAWL
  174-  185 (21.08/16.73)	KYSGEFVQSAYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      22.54|       7|      26|     749|     759|      21
---------------------------------------------------------------------------
  749-  759 ( 8.27/16.38)	LClcivAVLRH
  778-  784 (14.27/ 7.89)	LC....GVVKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.52|      24|      26|    1333|    1358|      22
---------------------------------------------------------------------------
 1335- 1358 (38.63/24.98)	NKRAYMNLVKKLRKELGDRQSDSL
 1360- 1383 (40.88/21.91)	KVRQLLPLPKQTRDVITCEPQGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.55|      17|      19|    1491|    1508|      23
---------------------------------------------------------------------------
 1491- 1508 (22.57/17.11)	EPAKSDKTSSNpATSTEE
 1512- 1528 (26.98/14.94)	KQSKTKKRNQS.ASKTED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05522 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPPMHCESKASPSPEKPDPEKEAKPLLKDKSVEGM
2) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN
3) LAMDSHGPRPPSPFDDPAEEHDRKETEGNSGIKLEDTGLSE
4) SHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLGNTQRFPHQSIQQTPMMSGMNHLGPQGVPSGIRPSQILPDQQQQQYLRQQQQQQQQMLRFQRQGLQQTQQQQQTAALVRQLQQQLSNTQTQQNNNPFGRY
5) SYYLEPLPLPPEEEEPPTPVALEPEKKAAEPAKSDKTSSNPATSTEERKKKQSKTKKRNQSASKTEDFVLGPSRGVSYGVGMPTDLLHHQPGSTMSRXAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPXSGVLPPGMGSM
530
15
467
1653
1462
565
61
507
1814
1614










Molecular Recognition Features






MoRF SequenceStartStop




NANANA