<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05508

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMSIPYACKIRHLPPHPKIKQKDESSSHECNQRLILLYGVGKERDEARHQLKKITKDILKILNKKSTTEMGVGDEGQKARKTKQEAFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNSEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAGKLFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSNNVNSSKSEDFHMRGLLDELNEDEVWGSSHALKARGKAVSIETASLSEYARYVLRTICQQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDLQTNNELFTTVLDMLGVLINGTLASDLSNASQGGPEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHMHNKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGEFSDQGKHAMDDEKKAKSRKRKSKSSSRADEYPQNNLYRVPPTYSPVSSQVMHPPQPALWGYSIMGQPQQPGFFVQNQPLPPEAFLVELHGAVYNQATHVWEDLFSLICGNYHCSEVNEHFTKLACLLSLLLKPALAKLTPENPSEVHMVQSSACSLDWGLPQRDACMVLQIRNTSLGSLQ
Length1145
PositionKinase
OrganismAmazona aestiva (Blue-fronted Amazon parrot)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Psittaciformes> Psittacidae> Amazona.
Aromaticity0.07
Grand average of hydropathy-0.292
Instability index51.06
Isoelectric point6.51
Molecular weight127648.35
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05508
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.68|      42|     217|     308|     350|       1
---------------------------------------------------------------------------
  308-  350 (72.13/59.30)	DNAANRYSFVCNALM.NVCMGHQDAGRINDIANLCAELtACCTV
  528-  570 (69.55/51.77)	DQWTLRQSWLELQLMiKQCMKEPGSGSVAEMNSLLDNI.AKATI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     183.67|      51|     217|     641|     702|       2
---------------------------------------------------------------------------
   10-   47 (58.09/24.51)	..........RHLPPHPKI...KQ.KDESSSHECNQRLI.LLYGVGKERDEAR
  641-  692 (80.69/58.23)	KAAGEELEKGQHLGSSSKKERDRQ.KQKSMSLLSQQPFLsLVLTCLKGQDEQR
  961-  997 (44.89/18.51)	RKSGEFSDQGKHAMDDEKKAKSRKrKSKSSSRADEYP................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.17|      50|     321|     734|     791|       3
---------------------------------------------------------------------------
  734-  791 (75.84/66.57)	NLVGGMFDtvqrstQWTTDWALLLLQIitSGTVDLQTNNELFTTVLDMLGVLINGTLA
 1052- 1101 (90.34/59.05)	ELHGAVYN......QATHVWEDLFSLI..CGNYHCSEVNEHFTKLACLLSLLLKPALA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.19|      17|     189|     209|     225|       4
---------------------------------------------------------------------------
  209-  225 (31.48/17.74)	QVFEGLCGVVKHV....VNPS
  254-  274 (24.71/12.57)	DLFSSACSKVKQTiysnVQPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.78|      37|     101|     908|     945|       5
---------------------------------------------------------------------------
  908-  945 (64.96/43.12)	VDRKVIkYEEQQHLLLYHMHNKPKPRSYYLEPLPLPPE
 1011- 1047 (72.82/44.46)	VSSQVM.HPPQPALWGYSIMGQPQQPGFFVQNQPLPPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05508 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGEFSDQGKHAMDDEKKAKSRKRKSKSSSRADEYPQNNLYRV
933
1004










Molecular Recognition Features






MoRF SequenceStartStop




1) MSIPYACK
2) RLILLY
3) YYLEPLPL
1
32
935
8
37
942