<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05505
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSVEKREEKQLELTLEALISQVADLKNSLVSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLLRNQVIIPLVLSPDRDEEIMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLITDAARISPDVAQKQIQSLNKMCSNLLEKISKEERESESGGLRQNKQTFNPADTNALVAAVAFGKGLSNRRPPGSGGSVQSGQPGAGAIIAGASGMQQVPMSGAPAQQQPMLAGVQMAQAGQPGKMPTGIKTNIKSASMHPYQR |
Length | 271 |
Position | Head |
Organism | Amazona aestiva (Blue-fronted Amazon parrot) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda>
Coelurosauria> Aves> Neognathae> Psittaciformes> Psittacidae> Amazona.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.492 |
Instability index | 54.14 |
Isoelectric point | 6.93 |
Molecular weight | 29625.45 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP05505
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.89| 25| 29| 70| 95| 1
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70- 95 (39.22/31.48) KTPLLRNQViIP..LVLSPDRD.EEIMRQ
99- 126 (35.67/23.38) RVPVFSHEV.VPdhLRTKPDPEvEEQEKQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 101.05| 30| 36| 179| 212| 2
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160- 191 (26.15/14.86) ....EERESESGG..LRQNKQTFnpadtNALVAAvAFG
192- 222 (50.11/20.94) KGLSNRRPPGSGG..SVQSGQPG....aGAIIAG.ASG
229- 251 (24.79/ 6.90) SGAPAQQQPMLAGvqMAQAGQPG...............
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.66| 25| 28| 5| 29| 3
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5- 29 (37.55/28.29) KREEKQLELTLEALISQVADLKNSL
35- 59 (42.11/32.56) KLENEYDRLTWPSVLDSFALLSGQL
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