<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05454

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEESYLGLRELVEKSQAESEGKGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLMTPRPKEVSNVSVTDGIAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKGGPIKLAESRRFVLGDDIERRMAVSDNPFSVLYTILHELCISLGMDTIIRQANVLRQGRWKEAIRSELISDSTTGQTANAAPMQLGQDGEFDSSGFRLPGLKVNYWLDEKNSGTAESDLSPFIKIEAGQDLQIKCQHSSFILDPLTDKEANISLDMCCIDVEKLILRAIACNRHTRLLDIQRQLCKNVQISQSPKDVILKRDVEVAREPHKVMKAEKMGFADCCGNEVLQVRAYGQAYIGLGLNIRSGRFLLQSPKNILPPSALLDWEEALNKGSATATEVFSSLRTRSILHLFAATGSFFGLKVYQQSQGTLKIPKAILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDTSNKANENIDAKEAMRVNKIDVDQMHIMKYENSTNLFDTKLHTLQSIESCDDMMDNGLPIQNMGDPLPLLPACSPSFSSIVDEIFECEHDSTLPSASHVGSCSLGLQGASTRAMSPMQDGASSHAQANVTSIVHPSVSLNSYFPSSSRHLQSTNTFSSSPVRNSSAIKLSGSKSNRDLSSLSSPSEHGSADGNNTLQLIPSSKVNSNQNPGQSSYSGGLRNSLPGHLAHVSSTIGGLGKAIPEGSDCASRKRSLSDFLLNLPSLQGLKSSEPSKRRKLSESMQSSPPLQAQRSNLQSRTKLTYGNILAERNNCVPATVYASVLLHVIRHSSLCIKHAQLTAQMDSRAIPYVEEVGMRSPSSNLWLRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNAGSTTTPWGAGVRIANTSEMDSHISFDADGVVLTYSTVDADSVKRLVSDLHRLANARAFARGMRTSIGVKLDDKLDDSQTSMGIKSQPVHKGNSDAADRLSEQAGKPFRIEAVGLMSFWFSYGPTHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVPSFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYTSMQKQTNNVPTQGPLTNGSSATTMHHASAPSNVAAAHLGNHNLHAAAMLSAAGRGGSGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQAAPHLNTSAPQSAASANRLNVTPGVHMSRPTSGVANQMAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELTAAEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLITWKKGFSQAHGDIATAQRARIELCLENHSGSASDDNTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNSHISFLAMDGSHGGRACWLQYEDWERCKQKVARAVETVNGSAAVGELGQGRLRMVAEMIQKQLQLCLQQLRDGSLSAGSTAS
Length1763
PositionTail
OrganismBrachypodium distachyon (Purple false brome) (Trachynia distachya)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Brachypodieae> Brachypodium.
Aromaticity0.06
Grand average of hydropathy-0.222
Instability index50.66
Isoelectric point7.97
Molecular weight192494.95
Publications
PubMed=20148030

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05454
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     317.65|      91|     137|    1173|    1269|       1
---------------------------------------------------------------------------
  738-  789 (60.17/25.39)	.................................QSTNTFSSSPVRN.SSAIKL..SGSKSNRDLS.........SLSSPSEHG....SAD.GNNTLQLIPSS.............
 1173- 1269 (139.19/86.66)	GPllALGGAI.....RPARMPvTVSSGYTSMQKQTNNVPTQGPLTNgSSATTMhhASAPSNVAAA.........HLGNHNLHAAAMLSAA.GRGGSGLVPSSLLPFDV...SVVL
 1306- 1408 (118.29/58.32)	GP..SVGGSLpcpqfRPFIME.HVAQGLNALEPAFMNATQAAPHLN.........TSAPQSAASAnrlnvtpgvHMSRPTSGVANQMAASlSRAGNAMLSSSGLASGIggaSVRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     200.77|      51|     137|     967|    1024|       2
---------------------------------------------------------------------------
  971- 1021 (92.36/72.63)	KAGSMSW....D.VRINDPHFKELWELNAGSTTTPWGAGVRIANTSEMDSHISFDA
 1655- 1688 (53.87/34.94)	..................PHM....NVAGGAAWLPYCVSVRLRYSFGDNSHISFLA
 1693- 1739 (54.54/38.32)	HGGRACWlqyeDwERCKQKVARAVETVNGSAAVGELGQG.RLRMVAEM........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     264.90|      92|     109|     166|     273|       3
---------------------------------------------------------------------------
  168-  273 (139.12/116.83)	TSVRY.KVLMTPRPKE.VSNVSVTDGIAVFRV.........DGEFKvllTLGYR..G.NLDLWrilhmellVGEKGGPIKLAESRRFV...LGDDIerRMAVSDNPFsVLYTIL.HELCISLGM
  275-  384 (125.78/72.29)	TIIRQaNVLRQGRWKEaIRSELISDSTTGQTAnaapmqlgqDGEFD...SSGFRlpGlKVNYW........LDEKNSGTAESDLSPFIkieAGQDL..QIKCQHSSF.ILDPLTdKEANISLDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.64|      12|      16|     800|     811|       4
---------------------------------------------------------------------------
  800-  811 (21.78/13.69)	SSYSGGLRNSLP
  818-  829 (19.86/11.65)	SSTIGGLGKAIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.81|      21|      23|     836|     856|       5
---------------------------------------------------------------------------
  836-  856 (35.23/20.22)	SRKRSLSDFLLNLPSLQGLKS
  860-  880 (36.58/21.29)	SKRRKLSESMQSSPPLQAQRS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.24|      15|      15|     611|     625|       7
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  611-  625 (26.85/16.67)	QMHIMK.YENSTNLFD
  627-  642 (22.39/12.75)	KLHTLQsIESCDDMMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.10|      19|      23|    1435|    1454|       8
---------------------------------------------------------------------------
 1435- 1454 (31.90/24.30)	Y.GGGWV....PlAALKKVLRGILK
 1455- 1478 (25.20/13.60)	YlGVLWLfaqlP.ELLKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.98|      30|    1113|     502|     531|       9
---------------------------------------------------------------------------
  502-  531 (50.60/28.67)	GSATATEVFSSLRTRSILHLFAATGSFFGL
 1616- 1645 (51.38/29.22)	GSASDDNTESSLAKSNIHHDRAHSSVEFAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05454 with Med14 domain of Kingdom Viridiplantae
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