Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MAASAAPPPVNLGHLQWRSPEYLLTTGGALQTAEQALDYFSYSPFFDKRSNNATLRMQMMFANGGMHGVDEERELRRLTGLEFAVSPLSRPQDDLFIIVKRQRSSPDDATVLGAFYILNGNVYQAPSLFEVVNERVLTSIHALSTSFSALTALKPAWTPQRGGAWEIKPPPAAVASLADASAAATTTDEPVPPVEGAEAQSLVEGELDAAAEDKVNGVVAPKAATADVERPGDAFNPLLFRALQATAARTTMEAMQDGQGAQGA |
Length | 264 |
Position | Head |
Organism | Rhodotorula graminis (strain WP1) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Sporidiobolales> Sporidiobolaceae> Rhodotorula. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.170 |
Instability index | 51.71 |
Isoelectric point | 4.74 |
Molecular weight | 28100.22 |
Publications | PubMed=26441909 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP05451 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 125.70| 39| 61| 159| 198| 1 --------------------------------------------------------------------------- 159- 198 (63.14/35.52) PQRGGAwEIKPPPAAVASL...ADASAAATTTDEPVPPVEGAE 221- 262 (62.56/30.40) PKAATA.DVERPGDAFNPLlfrALQATAARTTMEAMQDGQGAQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DLFIIVKRQR 2) FNPLLFRALQ | 94 235 | 103 244 |
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