<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05435

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGSDGQLVSLGGPPQAPQPPGAHGVRLSLLIDFLLQRTYHDITLLAELKIEIVQFASRTRQLFVRLLALVKWAGNAGKVEKCAMISNFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPSCIRDKIIPPDPITKLEKQTTLNQLNQILRHRLVTTDLPAQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLRILVEDKETGDGRVLVHSLQVNFIHELVQSRLFADEKPLQDMYNCLHSFCLALQLEVLHSQTQMLIRERWGDLVQVERYVPAKCLTLSVWNQQVLGRKTGTASVHKVDIKVDEADTSKPLQISHEPPLPACDSRLMERAMRIDHLSVEKLLIDSVHARSHQKLQELKAILRSYNPNDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGTDQSMLDDIEKSINDDMKRIISWLQQLKFWLGEQRCRQSVKHLPTVCSNTLHLANTTSHPVGALSKHLLFIKLTRLPQYYIVVEMFEVPGCPTELEYKYYFLSVSQLENEDGLSSAQLLQQYKPNLEELVMETTSSRGPRLGTKRKLSGDRGAVEPKKPKRSGEMCAFNKVLAHLVAMCDTNMPFIGLRCELSNMGIPHQGVQVEGDGCSHAIRILKIPPSKGVSEDTAKTLENCLLDCTFRLQGRNNRTWVAELVFSNCPLSSTSSKDQTPTRHVYLTYENPLSEPVGGLKVVEMFLSDWNSISQLHQCVLELARSLQDMPSYLSLFSEIRLYNYRKLVLCYGSTKGSSVTIQWNSATQRFHLSLGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLYDTLAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGVDMMDSLMPQLQPQQFPKQQPGPSVYPPLTSPPTPYHQNVTPSPSMMPTQSPGALDPSSPYTMVSPSQRAGTWPGSPQVSGPSPGARILGMSPGNPSLHSPVPDASHSPRAGPSSQAMPTNMPPPRKLPQRSWAASIPTVLTHTSLHVLLLPSPMPASCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQENLTIVSSNEPGVIMFKTEVLKCRVALNPKTYQTLQLKVTPENVGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRLPLAQEPACIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILKRFNDMHPPRQGECTIFASVHELMASLTLPPGGRP
Length1375
PositionTail
OrganismScleropages formosus (Asian bonytongue) (Osteoglossum formosum)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Osteoglossocephala> Osteoglossomorpha> Osteoglossiformes> Osteoglossidae> Scleropages.
Aromaticity0.07
Grand average of hydropathy-0.151
Instability index50.49
Isoelectric point8.58
Molecular weight153126.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05435
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     228.55|      38|      38|     995|    1032|       1
---------------------------------------------------------------------------
  962-  990 (43.45/17.24)	........SLMPQLQ.....PQQFPKQ..QPGPSVYPPL...TSPPT
  995- 1032 (74.86/35.30)	NVT.PSP.SMMPTQS.....PGALDPS..SPYTMVSPSQRAGTWPGS
 1034- 1071 (46.72/19.12)	QVSgPSPgARILGMS.....PG..NPSlhSPVPDASHSPRAG..PSS
 1076- 1104 (31.99/10.65)	TNM.PPP.RKLPQRSwaasiPTVLTHT..SLH..............V
 1105- 1131 (31.53/10.38)	LLL.PSP...MPASC...lvPGL...A..GSY.LCSPLER.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     382.87|     121|     209|     447|     624|       2
---------------------------------------------------------------------------
  447-  587 (191.50/137.70)	KSINDD.MKRIISWLQQLKFWLGEQRCRQSVKHLptVCSNT.................LHLANTTSHPVGALSkhllfikltrlpqyyiVVEMFEVP.GCPTELEYKYYFLSVSQLENEDGLSSAQLLQQYkpNLEELVMETTSSRGPRLGTKRKLSGDR
  658-  797 (191.37/143.36)	KGVSEDtAKTLENCLLDCTFRLQGRNNRTWVAEL..VFSNCplsstsskdqtptrhvyLTYENPLSEPVGGLK................VVEMFLSDwNSISQLHQCVLELARSLQDMPSYLSLFSEIRLY..NYRKLVLCYGSTKGSSVTIQWNSATQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     262.01|      66|     453|     798|     869|       5
---------------------------------------------------------------------------
   10-   53 (52.42/28.21)	..LGGPPQAP..QPPGAHGVRLSL.LIDF........LLQRTYHdiTLLAELKIEIV...................
  798-  869 (103.77/79.45)	FHLSLGTVGPNSGCSNCHNIILHQlQEMFnktpnVVQLLQVLYD..TLAPLNAINKLPTV.PM.LGLTQRTNTAYQ
 1260- 1325 (105.82/65.67)	FCLTIPPSAPPIAPPGTIAVVLKS.KMLF.....FLQLTQRL....PLAQEPACIIVPIVyDMaTGLTQQADIPRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.97|      32|     149|      60|      98|       7
---------------------------------------------------------------------------
   60-   91 (54.91/28.90)	RQLFV.....RLLALVKWAGNAGKVE.....KCAMISNFLDQ
  213-  243 (46.70/22.77)	RLLKL.....RILVEDKETGD.GRVL.....VHSLQVNFIHE
  270-  309 (38.36/23.35)	LQLEVlhsqtQMLIRERW.GDLVQVEryvpaKCLTLSVW.NQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.79|      27|     280|     906|     933|       8
---------------------------------------------------------------------------
  906-  933 (45.14/32.31)	GAYSLfDNTKIVEGFYPA....PGLK.TFLNMF
 1193- 1224 (40.65/23.62)	GPWSQ.EELQVLEKFFETrvagPPFKyNTLNAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.47|      30|     225|     159|     188|       9
---------------------------------------------------------------------------
  159-  188 (49.84/30.24)	LNQLNQILR......HRLVTTDLPAQLANLTVANGR
  380-  415 (44.63/26.31)	LQELKAILRsynpndNSFIETALPTLVIPILEPCGR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05435 with Med14 domain of Kingdom Metazoa
Unable to open file!