<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05433

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGSDGQLVPLGGPSAPQPPPPGAPAAHGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAFLFVDTADRLASXXXARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPIMKQEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHTLQVNFIHELVQSRLFADEKPLQDMYSCLHSFCLSLQLEVLHSQALMLIRERWGDLVQVERYIPAKCLTLSVWNQQVLGRKTGTASVHKVTIKIDEADGSKPLQISHEPPLPACESKLMERAMKISHLSVEKLLIDSVHARSHQKLLELKAILKAHNVNDSSFIESALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYALDQSMLDDIEKSINDDMKRIISWLQQLKFWLGKQRCRQSVKHLPTVCSDTLNLANASSHPAGSLSKHHLFIKLTRLPQYYIVVEMFDVPGCPTKLEYRYHFLSVAQLEGDDGPPSAQLLQQFKPNVDELVLDAIPSKGVRPGTKRKLSGEQAAAIEPKKPKRSGEMCAFNKVLAHLVAMCDTNMPLIGLRCELSNMGIPHQGVQVEGDCCSHAIRILKIPRCKGVSEETQRALECSLLDCTFRLQGRNNRTWVAELVFCNCPLGSTSSKDQASTRHVYLTYENPLSEPVGGRKVVEMFLSDWNSISQLYECVLEYTRCLPDVPSYMSIFSEVRLYNYRKLVLCYGSTKCSSVTIQWNSANQRFHLSLGTVGPNSGCSNCHNIILHQLQEMFNKMPTVVQLLQILADTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPMHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLSMFMDSSQDARRRSVNEDDNPPSPVGMDLLDPLASQIQPQLQFLKQQPGAGIYPALTSPPSAYHQNIAPSPSMMPTPSPGALDPSSPYPMVSPGQRAGTWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDVSQSPRAGASKYQCNVVKVLAGFTVTSLTAVFVPAVKVPTNMPPPRKLPQRSWAASIPTVLTHSALNVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEANVSVFRLCWSH
Length1200
PositionTail
OrganismScleropages formosus (Asian bonytongue) (Osteoglossum formosum)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Osteoglossocephala> Osteoglossomorpha> Osteoglossiformes> Osteoglossidae> Scleropages.
Aromaticity0.07
Grand average of hydropathy-0.110
Instability index50.61
Isoelectric point8.69
Molecular weight132896.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05433
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     268.51|      67|      84|     968|    1050|       1
---------------------------------------------------------------------------
  968- 1050 (120.93/80.33)	PSpvgmdlldplasqiqPQLQFLKQQPGAGI..YPALTSPPSAYHQNIaPSPSMMPTPSPGA.............LDPS..SPYPMVSPGQRAGTWPGSP
 1055- 1086 (50.12/19.36)	PS........................PGARI........................PGMSPG...............NPSlhSPIPDVSQSPRAGA.....
 1089- 1167 (97.46/41.29)	.................YQCNVVKVLAGFTVtsLTAVFVPAVKVPTNM.PPPRKLPQRSWAAsiptvlthsalnvLLLP..SPTPCLVPGL.AGSYLCSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     372.08|     116|     231|     417|     552|       2
---------------------------------------------------------------------------
  277-  399 (181.67/121.64)	CLHSFCLSLQLEvLHSQAL..MLIRERWGDLVQVERYIPAKCLTLSVWNQQV...LGRKTGTASV.HKVTIKIDeAdgskpLQISHEPPLPACESKLMERAMKISHLSVEKLLIDSVHARSHQKLLELK
  428-  549 (190.41/139.38)	CGRSECLHIFVD.LHSGMFqpMLYALDQSMLDDIEKSINDDMKRIISWLQQLkfwLGKQRCRQSVkHLPTVCSD.T.....LNLANASSHPAGSLSKHHLFIKLTRLPQYYIVVEMFDVPGCPTKLEYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.99|      14|      83|     585|     598|       3
---------------------------------------------------------------------------
  585-  598 (26.14/14.75)	IP.SKGVRPGTKRKL
  670-  684 (21.85/11.16)	IPrCKGVSEETQRAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.25|      13|      95|     758|     774|       6
---------------------------------------------------------------------------
  758-  774 (21.51/16.86)	QLYECVleytRCLPDVP
  882-  894 (25.74/10.97)	TAYQCF....SILPQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.70|      47|     446|     159|     211|       7
---------------------------------------------------------------------------
  159-  211 (70.00/60.66)	IIPPDPimkqEKQTTLNQLNQILRHRLVTTD.......LPPQLANLTVANGRVkfRVEGE
  606-  659 (78.69/50.97)	IEPKKP....KRSGEMCAFNKVLAHLVAMCDtnmpligLRCELSNMGIPHQGV..QVEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.43|      13|      20|     846|     859|       8
---------------------------------------------------------------------------
  846-  859 (17.49/13.58)	PTvVQLLQILADTQ
  869-  881 (23.95/14.07)	PT.VPMLGLTQRTN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05433 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YHQNIAPSPSMMPTPSPGALDPSSPYPMVSPGQRAGTWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDVSQSP
1009
1082










Molecular Recognition Features






MoRF SequenceStartStop




NANANA