<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05431

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTSRTPMGVQPRPPQRTVSSSSLPVQRPAQQRSLSQQHQQFMPASPVRKDSSFIDLTGDSTDVAPNRFAPTPRRGGSRLKLELSNELSSGHMSITGSPQSLTPSRMLPVSDPFETNTSSPAVSRASHQDLDNMPMPMPRRRPRASQPISVPKIVKPAPALTTTKKDSRPKPYTVEIPPLAPRFITPRTDAPNRTPVDPFSKGLSSGYADFFPWNGAHHEDEWNGEAITKGTWDKVNLNVPETASAKLAIFPALKQKSGLNALSTIFMGVLNQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPVISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVSAFGESEWKARVTYAVRLATNLYSEQLLDRDHYLDWVVSGVENSPQSKLPMWILIAQIYWRDLMRLRKYGRRLSFALLSHLHVIHNDPDQDILVQLSSRLSALLSSLLRTNPESFVYPSVWPKYRETLQHVLSSDDETIQNTINAIQIRNSRLLVSSSNSLPAGRNQLVKLLDAALKEPIDRELARKCWATSDSKPLIIKTLVEWATSFHRPGLAKVYVAANLIRAWSPFRVNPTTAILEILDGIAAHDKTRKELVYLLVTELVRTGQFSVPQYIQWVIARGGYHDAADIDPDDGPCSTRLLLELPLHALSDKRRAERGNLLRRAGNYSIADEEQNIMNAVKCLKHSLGLPLPPGDPLCGRKPLSLQKLLRRIRNSSKALRSCVGAQLRDILTIRFSRKEPSPMSLAMFTSVREIMETVEDFTMLSDVLKASAKSGDAEILASCADTINSNLQIFLAIGSAENLFNSLIQRLKSINQEQGIVPRPLLAALSTLSRRMAGHEDIAHSLSDELLQSDRNNAIDACSPVSDIMSIPAQSAEGEVAEEIEKLLSSGTRLDPPTMNRLFRTIIPRLERGWAKKDDARRIFATLLARTRVFDAQHFDKLMMDWTSHVRSMTERPRLSDLFPLLISTGCLAMPIILGTASAPSPAPAPNMEAATKQHGSATYLQELLQLIITPLPAATGLSPEEGYRFRTEQRCAKSEQSKGLLNLVKNALLEYSGLRHHSSGIDLPLNNTACQESLLETLRLLVLVDSIGVSHALSLKSLPEAGDLVQKVTTNLLVPGEPGESFMSFDRILQLANELTLPFCQLKLNLDLSMSQQHLGGAEDHGTRFDLFAKAMDRAIEAGNIMWTSLLPCLSDDITQHLKSQAQTSFLDLIPSTKASNLTESASNQSIHMAENLLEVVEAIVSGHPPPKMAQLSIAMVEKLTDLWEIIASGPQERPGVHAAALRHWLPAMLRFVTLHSLSSEPPSAPLPSASATRPPIPAGHDTRARIVLVLCGLMLELETLPPGTTGSLPQQVMDIAILLVDALPEDLRAQCAKSILLTPGSTPSLHTSSDPRLYYLFSAPHPGPAEHLMLSHREKPATAHSAAARGMGAMYGIGPAVQERLSPFVLRRWELLSEPTPNVGENDTSLSLGLFEAIKIQ
Length1534
PositionKinase
OrganismNeonectria ditissima
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Neonectria.
Aromaticity0.05
Grand average of hydropathy-0.222
Instability index47.78
Isoelectric point9.02
Molecular weight169403.75
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05431
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.69|      32|      41|     136|     169|       1
---------------------------------------------------------------------------
  136-  169 (55.09/30.67)	PM.PRR.RPRASQPISVPkiVKP.APALTTTKKDSRP
  178-  212 (48.60/22.00)	PLaPRFiTPRTDAPNRTP..VDPfSKGLSSGYADFFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1265.47|     364|     383|     579|     961|       2
---------------------------------------------------------------------------
  303-  544 (240.64/169.20)	..................................................................................................................................................................KDLANPVISLR.R.LSRTIPHG..IRGRTLLD.QCLN...KNV.PTERAvwLAKC..VGAN.....EIRaFKRKGVNG.AFVMggeLKWARDWTVFVEQF......VD...AVVSA...FGESEWKARVtyAVRLATNLyseQLldrdhYL...dwVVSGVENSPQSKL........PMWILIAQ...IYWRDLM.RLRKYGRRLSfallSHLHVIHNDPDQdiLVQlSSRLSALLSSLLRTNPESFVYPSVWPKYRETLQHV......LSSDDETIQNTINAIQIRNSRLL
  579-  961 (569.80/486.99)	WATSDSKPLIIKTLVEWATSFHRPGLAKvyvaanLIRAWS.........PfRVNPTTAILeILDGIAAHD...KTRKELVYLLVTEL.VRTGQFSVPQYIQWVIAR..GGYHDAADIDPDDGpcsTRLLLElPLHALSDKRRAERgNLLRRA.GNYSiadeeQNIMNAVKCLK.HSLGLPLPPGDPLCGRKPLSLQKLL...RRIRNSSKA..LRSC..VGAQLRDILTIR.FSRKEPSPmSLAM...FTSVREIMETVEDFTM....LS...DVLKASAKSGDAEILASC..ADTINSNL...QI.....FL.....AIGSAENLFNSLI........QRLKSINQEQGIVPRPLLAALSTLSRRMA....GHEDIAHSLSDE..LLQ.SDRNNAIDACSPVSDIMSIPAQSAEGEVAEEIEKL......LSSGTRLDPPTMNRLFRTIIPRL
  965- 1343 (455.04/339.99)	WAKKDDARRIFATLLARTRVFDAQHFDK......LMMDWTshvrsmterP.RLSDLFPLL.ISTGCLAMPiilGTASAPSPAPAPNMeAATKQHGSATYLQELLQLiiTPLPAATGLSPEEG...YRFRTE.QRCAKSEQSKGLL.NLVKNAlLEYS.............GLRhHSSGIDLPLNNTACQESLLETLRLLvlvDSIG.VSHAlsLKSLpeAGDLVQKVTTNL.LVPGEPGE.S......FMSFDRILQLANELTLpfcqLKlnlDLSMSQQHLGGAE........DH.GTRF...DL.....FAkamdrAIEAGNIMWTSLLpclsdditQHLKSQAQTSFLDLIPSTKA.SNLTES.A....SNQSI.H.MAEN..LLE.V..VEAIVSGHP.......PPKMAQLSIA.MVEKLtdlweiIASGPQERPGVHAAALRHWLP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.96|      38|     222|      20|      73|       3
---------------------------------------------------------------------------
   28-   73 (64.65/58.70)	PA.QQRS.LSQQHQQFMPASPVRKDSSFIDltgdstdvAPNRFAPTPR
  251-  290 (59.31/26.80)	PAlKQKSgLNALSTIFMGVLNQRRHRGQIN........APSTFKPPPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.95|      51|      99|    1347|    1399|       4
---------------------------------------------------------------------------
 1347- 1399 (83.70/42.96)	RFVTLHSLSSEPPSAPLPSASATRPpiPAGHDTRARIVLVLCGLMLEL.ETLPP
 1449- 1500 (87.25/39.99)	RLYYLFSAPHPGPAEHLMLSHREKP..ATAHSAAARGMGAMYGIGPAVqERLSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05431 with Med12 domain of Kingdom Fungi
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