<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05423

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMPRSSSERNGDWLRPVDDEEDDAFLSGPEDAEAKGCLEDGGRSTLNLTPEALPVYMTIHRVRRLVLASIDDPYTLEHFRDPKMNALVVRPLVDRLYNPDDISVVYCLLANRVSFLRDQSKTVHQSVNVARATLCELLASRVLRRFHEDNPGPQGLLLLAHILVEGFDPFQGAPDHVARRGRNRGGQSQWPGQEKNANEKKVTALELAILSESKTFISSSACQRAVDAVHDGEIVYTPQSLMDILPDHYKRRPISLYDPRKAPLLNHHRLIVPRTRNLVEMLQFIILLGLYVMTMVSRHSEFNPWEFAFIIYSAGWVLEKLAAIIEHGWGVHAQNLWAFLDITFTAIFGAYLLARLSDLLLDQLHSGWGLPILCIAAPIMLTRVAFNLLPNNIVFISLHAMMRDFTVLTFLATWCFTGFLLALQWLVAAGNDGREEFSWVVVGKWMLWIWFGLDGEGIEESVRFHTILGPALMISFAFLGNTLFLTILIAMLTNTFSKIIADETAEIMFRRAVLTFEGVKSDSIFAYPPPFNIVALIVLLPLKLVVSARVFHIINVALIRTLNFFTLLMISFFERRRFAAQTNPAKKHSKWQFMSFSPYGDVQAVFRAAPPPDIADIIDQLDPLSEVPILEDDLMPTMLGDNPRSKLRRWRLLRRETTGPDESAEEERPGHSRGASLDENLKNRHNHDPLHPPHSFTHHRYRHAPPLQLPARERTMASGDDGPPLSLRPHPVADRKPKNLAEFIGRVNAQPGGFRAVTEAKLREEIRLREESARDGDVADDDDVDMSEGGDDEDDEDKDPNEARIEVLRNIDVAGNTALLTLDFLSLLLSKQNPTQAGVTLSQGLREMVGIGTMGADKLDDSNVTPAKVKEQEEVAVGWTLMEINKTRDAADAASSFLQREIAAEGKYWEEIVAVQKSGWSISKVPQERHSLGVRFGFSEAAPEFRSNGLAPMRRGVDGAVQLDCGRLGGVSERLVVTYEKDGQVTGRSSLPAQTTDDAPLEARVLEARNTIFSQELWHELTREARTLAAYDVKPHGSSITCALDETTSIAVELVPLGSQPSEASLPDNEMAEAISLALHILLSYAHRHNELMRTRPMPPHIPRNRGQSTCALLRPIIARLMHMRNIRACTEHIGALVQSLQKAGMLARFTLRTSPSATADADIGSRGPNQPSASQTMIRNMLQPIDFLTDITLLPDMSLTVRGRTFLFPVTATYFHVLLPPGSPLASICPPYKDGYPDLKALADYLRTVTARALTEHFLPTLPPPPPGSEWIKSIRGTSIRDFEKEDFELRFDIVDVSAAPSLRVTRTSLVDGRPASRDWTWSSGPSTASETNSVQDTVAQVFNEVLS
Length1348
PositionHead
OrganismNeonectria ditissima
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Neonectria.
Aromaticity0.08
Grand average of hydropathy-0.173
Instability index48.67
Isoelectric point5.77
Molecular weight150432.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05423
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.02|      31|      34|     746|     778|       2
---------------------------------------------------------------------------
  746-  778 (47.29/38.16)	VNAQPGGFRAVTEAKLREEIRLreESARDGDVA
  783-  813 (53.72/36.60)	VDMSEGGDDEDDEDKDPNEARI..EVLRNIDVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     172.25|      36|      36|     317|     352|       3
---------------------------------------------------------------------------
  261-  292 (30.18/12.26)	....APLLNHHRLIvpRTRNLVEMLQ..FIIL..LGLYVM
  317-  352 (62.47/32.37)	LEKLAAIIEHGWGV..HAQNLWAFLDITFTAI..FGAYLL
  356-  388 (46.99/22.73)	SDLLLDQLHSGWGL..PILCIAAPIMLTRVA...FN..LL
  394-  420 (32.61/13.77)	FISL............HAM.MRDFTVLTFLATwcFTGFLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.26|      48|      68|     989|    1043|       4
---------------------------------------------------------------------------
  989- 1043 (67.68/64.22)	SLPaqttDDAPLEARVLeARNTIFSQELWH.ELTReARTLAAYDVKPHGSSiTCAL
 1064- 1112 (85.58/55.03)	SLP....DNEMAEAISL.ALHILLSYAHRHnELMR.TRPMPPHIPRNRGQS.TCAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.99|      70|      79|     472|     544|       5
---------------------------------------------------------------------------
  472-  544 (108.09/70.57)	MISFAFLGNTLFLTILiaMLTNTFSKIIADET..AEIMFRRAVLTFEGVKS.DSIF.AYPPPfNIVALIVLL.PLKLV
  552-  626 (104.91/59.27)	IINVALIRTLNFFTLL..MISFFERRRFAAQTnpAKKHSKWQFMSFSPYGDvQAVFrAAPPP.DIADIIDQLdPLSEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.19|      36|      40|     866|     904|       7
---------------------------------------------------------------------------
  866-  904 (50.51/40.55)	AKVKEqEEVAV...GWTLMEINKTRDAADAASSFlqREIAAE
  905-  943 (60.68/37.46)	GKYWE.EIVAVqksGWSISKVPQERHSLGVRFGF..SEAAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.91|      25|      40|    1195|    1224|       8
---------------------------------------------------------------------------
 1195- 1224 (42.99/31.57)	PDM.SL.....TVRGRTFlfpvtATYFHVLLPPGSP
 1237- 1267 (37.91/17.85)	PDLkALadylrTVTARAL.....TEHFLPTLPPPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.12|      65|      68|      25|      92|       9
---------------------------------------------------------------------------
   25-   92 (97.73/84.38)	LSGPEDAEAKGCLEdGGRSTLnLTPEALPVYMTIHrVRRLVLASIDDPYTLEHFRD....PKMNALVVRPLV
   95-  163 (102.40/72.94)	LYNPDDISVVYCLL.ANRVSF.LRDQSKTVHQSVN.VARATLCELLASRVLRRFHEdnpgPQGLLLLAHILV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05423 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RWRLLRRETTGPDESAEEERPGHSRGASLDENLKNRHNHDPLHPPHSFTHHRYRHAPPLQLPARERTMASGDDGPPLSLRPHPVADRKPKNLAEFIGRVNAQPGGFRAVTEAKLREEIRLREESARDGDVADDDDVDMSEGGDDEDDEDKDPNEARIEV
648
806










Molecular Recognition Features






MoRF SequenceStartStop




1) RNGDWLRPVDDEED
8
21