<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05419

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLILDNAMPVGLNDVDDLFGDGVGLSLPAGRTQSKQLHQRMDELRSRGCCQAVAWSRTGTIASITPDGLSVELRCLRRNPENGSWDLSDPTKCHLVSGSATIPIVHLAWAGTSTPDLAVIDSIGRVTIVSFSIALNHPYLQRKWDTDSIDDMHGVMGAYWLGIAPASQQSYNVMYGPANKHGNGYTYESSFVHASGPTHPTPAKSALFTVSSNGTLRMLWSQSNNRIEETTMELESVNSSDDQVTHATFGSEKKSLILALATTSKQLSLVKIEIQWGAAAQSDKSSAQQAKVLSPSLVEKHLATTNWLQGGTSDISHNEYMAELSHLEVLPSLIDNTGKNIAPPMIVAIRSRAPSEGSYQMAQSILDRWEAVEQRQNLHPAFEQLGRRNSVSSEVPNGTQLRKIDPIVINKVVIGFHAINFGKVLVLAFADGSVEYRDRFTFEELYTTEDTTKVMSLRQVGWTFADEGPCQQVAFSPTYCSMIQMGDDGKVRWNRLHRPLDDIGESMQDAPYSASVAGLTVSAAPSIFYSNNYDDILAIARPFTTKKRFIQDWVTELIRMLKIQVDYSEDTHHDSLVRNGSLQSCLSIMNALGFRGEFNPRSFQGKLSMLSLNVRNVVVLITIASNTPLTAREKLSPLDEPEVVETLAGCAKWSLDLLAWLIDCLFELMNDDKFMALMTPQRFNEIAPYLSNTNNVALHFLLSSSSRGFLSAVCRRLGHLEALSARAIDFYRRQSAAPDQSSSGKAAPQLQQAYQRMQHATSSGLVKVGEFEKLLTVLGNDIRQAYQNILPALVKAQANAPQGKQIDMAVKTTRVQFELALLLSASPPPAFLQIMIKIFNKDLRAFRNLTDPSRLFFANYDLLEAQDDKRSLAAKKAAGMMYVDVFKRLEIKPGSKQWRRCTRCSGVMVDVFGSRPGFTFVLGQQRRCSCGGHWTLLQKGKLS
Length944
PositionTail
OrganismNeonectria ditissima
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Neonectria.
Aromaticity0.08
Grand average of hydropathy-0.203
Instability index47.35
Isoelectric point7.87
Molecular weight104445.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05419
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.70|      23|      24|     884|     907|       1
---------------------------------------------------------------------------
  884-  907 (41.33/32.97)	VDVF.KRLEIKPGSKQWRRCTrCSG
  910-  933 (41.37/27.88)	VDVFgSRPGFTFVLGQQRRCS.CGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.05|      37|     327|      29|      75|       5
---------------------------------------------------------------------------
   33-   69 (68.03/60.50)	TQSKQLHQRMDELRSRGCCQAVAWSRT.GTIASITPDG
  453-  490 (66.02/35.06)	TKVMSLRQVGWTFADEGPCQQVAFSPTyCSMIQMGDDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.35|      12|      29|     750|     761|       8
---------------------------------------------------------------------------
  750-  761 (22.66/16.27)	QLQQAYQRMQHA
  782-  793 (21.69/15.25)	DIRQAYQNILPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.30|      29|     684|     108|     136|      10
---------------------------------------------------------------------------
  108-  136 (48.38/29.82)	LAWAGTSTPDLAVIDSIGRVTIVSFSIAL
  794-  822 (47.93/29.48)	LVKAQANAPQGKQIDMAVKTTRVQFELAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05419 with Med16 domain of Kingdom Fungi
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