<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05411

Description Cyclin dependent kinase 19 variant
SequenceMDYDFKVRTSVERTKVEDLFEYEGRKIGRGTYGHVYKAKRKETFATSDINKLISADQKEYALKQIEGTGLSMSACREIALLRELKHPNVINLQRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKANKKAVYTPKAMVKSLLYQILDGIHYLHSNWILHRDLKPANILVMGEGIERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPHDKDWEDIKKMPEHPTLLKDFKRNNYQTCSLMKYMDRYKIKADTKAFHLLSKLLMMDPTKRFTSEAAMADPYFQEDPLPTSDVFAGCPIPYPKREFLSDEEQDDKSDSSKMIAKNPQGQNPAANAPNDQSHGPNAKRVRLAPPHPGNNSGSQMTGGPPDFHGQHVGQQQQPHVQQHPSAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHASQSGSSNHSHGHHPQHPAQQNNMQGVMHPNYSNHPGHPQQQSHPQQNNSFNQRF
Length547
PositionKinase
OrganismDaphnia magna
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia.
Aromaticity0.08
Grand average of hydropathy-0.944
Instability index52.84
Isoelectric point8.87
Molecular weight63232.35
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05411
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     115.65|      15|      15|     453|     467|       1
---------------------------------------------------------------------------
  436-  450 (26.90/ 8.23)	QHVGQQQQPHVQQHP
  453-  467 (32.32/11.25)	QQQQQQQQQQQQQQQ
  469-  483 (32.32/11.25)	QQQQQQQQQQQQQQQ
  484-  496 (24.12/ 6.67)	Q..QQQQQQQHASQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.55|      14|      27|     499|     515|       2
---------------------------------------------------------------------------
  499-  514 (25.98/14.47)	SNHShgHHPQHPAQQN
  522-  535 (30.57/ 7.96)	PNYS..NHPGHPQQQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     137.60|      26|      27|     376|     401|       3
---------------------------------------------------------------------------
  324-  343 (22.22/ 9.15)	......SKLLMMDPTKRFTSEA...AMAD
  348-  372 (39.32/21.77)	EDPLPTSDVFAGCPI.PYPKRE...FLSD
  376-  401 (41.39/23.29)	DDKSDSSKMIAKNPQGQNPAAN...APND
  405-  432 (34.67/18.33)	GPNAKRVRLAPPHP.GNNSGSQmtgGPPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.79|      16|      26|     250|     267|       4
---------------------------------------------------------------------------
  250-  267 (22.23/20.92)	EDIKtSNPyHHDQLDRIF
  279-  294 (30.56/17.20)	EDIK.KMP.EHPTLLKDF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05411 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLSDEEQDDKSDSSKMIAKNPQGQNPAANAPNDQSHGPNAKRVRLAPPHPGNNSGSQMTGGPPDFHGQHVGQQQQPHVQQHPSAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHASQSGSSNHSHGHHPQHPAQQNNMQGVMHPNYSNHPGHPQQQSHPQQNNSFNQRF
362
547










Molecular Recognition Features






MoRF SequenceStartStop




1) HSHGHHPQHP
2) QQQQQQQQQQHA
501
482
510
493