<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05404

Description MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12
SequenceMLYDSGSSNNTHGSKLNLIEAGSSPAAHLESSTARPGPSSAPITDFGPAINQGPTWRPRLHPGSTALGKPDFFPPDTDAEQLTEQVIRLGITNRPAVGNETMTANDMIYDRLTGANVLDTMGSMMDEILMRREELQRDKISSSSHRAPPRVTLNEVKLAAYMRDLGDPSVPLQRLARSVPHGYRGERMLDMLWMGGVAPTPASSSAAAAAAARSSATASQAASVLPQSPRNPVELHRAVWFIRVVGASEISSSRARQNSNYTAEWTSTFNGWLRKQLAELNIAPTASMYQAAHSSPASPAPTNRTPAHARSQPIAASSPYSASANGHSLISSRDSIILQQPDLEARWFAKWEYSIGLAQALVAESLLDIRVFALWIFEQLGTASLAQLPFVLTLAQEHAWVALDALILQRALLQSLCSCITELRKAELPEDNKNTHLILKEACALVRFLFDSDSDAFVSPKLWSQYGATIRKVVDDSHDDVETSRAAAHRREKLNNIDRRAQACLLGDLVVSSDEVSASRCDVELLDDFSVDDLDVEALADAYFARSKAQYSIQDKLCNVLIWATTQWRSGQHRPLLAARLVWTYHSRSQDASARLAHGWRAVDLQTVLFDWLSSVDKAQRDRGNPPSAVLQSLELESVIILVGELIRLGCFSFSKYLQRLTARGMTAGPTAPLKGTPPGSFQASQASSESEASLHQRVLRSVPLAAATPALSSQRRSAIYGTRLKESHEEASERRLRRELSNALPWLHGASPQEGNNASSSSVWKEQVPHLWSASRFTLAKVITSDLMPSIHSLERSLTVDEICILEVILAHARDHVALSQLLSSQLLLLAFMEDSEALEVLTSCICKHALCFAALDTLNQLSSAVSDLYIQCAGDDISPWGASCSEAFQRVAALRNLRRHISCNREEEQTSASKGHCRTESRPSGHLHDQFVEIARRLASDLDVRAAMRSVQAIAGPIAGQSILSAALHVVSEGASDGATIALVQWVRHATWTASDLHTVLRSWASQSEHNAANEGSELFLLRCVASGALRMRDLYASFVLPALELEAEENGAPPIEKQNKRSIKVATVAAIIKGSSSPRETSAALRLDSRHRLRLEAESATVTGSIGETSLLFRVLVLLLHLPNHDAAVLACNELLSNLSVRCCIMIKAFELFSIVSEVSRSVWGSNPSQVLSQVFASVNQAGLSTVNPSSIDAQMIFQRLDPWRCNLTVAEIAHITGKVATADASEHLRSQNALTSLSVAIFEPLCLASNSSLQNQLIRHTKHISTFQGRLVDLCIEELLRHLHSSSRRAGPTHSWLHDSLQTLAQVLHSQTRASISPHTLILASQLLNAIAAGFEITSSSRDCRDLSLIPLDVSVRASLGCARLAGLWTSADARSTAPRLLEAMCACAVNCSLEALNDFDVIVDAMSALMEDMPPDCVSSAQTSISSILAQVCVRSAIPDFAQARLQALAMPATITTQTHFAGATSDIILASSMTSAAVKGNFSQAPFKAWELHDHMDADTLSRAQARLPGSTILGGGSATSHPPSVSMIDADEVGYAAVNLANSGSVSLLQVGAVKTRERVASASGLNDYMYPTRSPHTSIGADEPEHWAAHESERTYGEGRAGDTTYARDARTGSDLLALDRAREDGGEAALIPEELRAADRALAQRALAAAAAEAAARAAEEAVKKAEAAAALAAAAKVVQTTPQRPKPVSKGTRQAPATSAKSRKRKEPPDSPDTASRSSTRGGRGRGRGRGKEAKAV
Length1747
PositionKinase
OrganismCeraceosorus bombacis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Ceraceosorales> Ceraceosoraceae> Ceraceosorus.
Aromaticity0.05
Grand average of hydropathy-0.150
Instability index49.23
Isoelectric point6.54
Molecular weight188412.65
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05404
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     628.39|     221|    1452|      10|     271|       1
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   10-  271 (320.83/256.50)	NTH..GSKLNLIEAGSSPAA..................HLESSTARPGPSSAPitdfGPAINQGptwrprlhpgstalGKPDFFPPDT...DAEQLTEQVIRLgiTNRPAVGNETMTANDmIYDRLTGANVLDtmgSMMDEILMRREELQRDKISS.SSHRAPPRVTLNEVKLAAYMRD..LGDPSVPLQRlARS.......VPHGYR.GERMLdmlwmggvaPTPASSSAAAAAAARSSATA...SQAASVL..........PQSPRnPVelHRAVwfiRVVGASEiSSSRARQ...NSNYTAEWTSTFNG
 1463- 1733 (307.57/166.91)	QTHfaGATSDIILASSMTSAavkgnfsqapfkawelhdHMDADTLSRAQARLP....GSTILGG..............GSATSHPPSVsmiDADEVGYAAVNL..ANSGSVSLLQVGAVK.TRERVASASGLN...DYMYPTRSPHTSIGADEPEHwAAHESERTYGEGRAGDTTYARDarTGSDLLALDR.AREdggeaalIPEELRaADRAL.........AQRALAAAAAEAAARAAEEAvkkAEAAAALaaaakvvqttPQRPK.PV..SKGT...RQAPATS.AKSRKRKeppDSPDTASRSSTRGG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     192.40|      62|      71|     868|     930|       2
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  868-  902 (43.80/24.44)	.......................................SDLYIQCAGDD..ISPWGASCSE..AFQRV..AALRNLRrH
  903-  971 (81.11/44.80)	ISCNREEEQTSASKGHCRTESRPSGHLHdqfveiarrlaSDLDVRAAMRS..VQAIAGPI....AGQSIlsAAL.....H
  973- 1025 (67.49/35.60)	VSEGASDGATIALVQWVRHATWTASDLH......................tvLRSW.ASQSEhnAANEG..SELFLLR..
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     379.80|     120|     194|     291|     418|       3
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  291-  418 (187.73/124.13)	AAHSSPASPAPTNRTPAHARSQPIAASSPYSASANGHSLIssrDSIILQQPDLEArwFAKWEYSIGLAQALVAESLLDIRVFAL..WIFEQLGTASLAQLPFVL.TLAQE......HAWVALDaliLQRALLQSLCS
  487-  615 (192.08/108.21)	AAHRREKLNNIDRRAQACLLGDLVVSSDEVSASRCDVELL...DDFSVDDLDVEA..LADAYFARSKAQYSIQDKLCNVLIWATtqWRSGQHRPLLAARLVWTYhSRSQDasarlaHGWRAVD...LQTVLFDWLSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     206.49|      53|     308|     750|     825|       4
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  750-  804 (81.37/39.78)	GASPQEG.NN..............ASSSSVWKEQVPHLWSASRFTLAKVITSDLMPSihSLERSLTVDEI
 1054- 1112 (55.45/18.30)	GAPPIEK.QNkrsikvatvaaiikGSSSP..RETSAALRLDSRHRLRLEAESATVTG........SIGET
 1151- 1204 (69.67/43.75)	KAFELFSiVS..............EVSRSVWGSNPSQVLSQVFASVNQAGLSTVNPS..SIDAQMIFQRL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.99|      19|      23|    1273|    1292|       5
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 1273- 1292 (29.65/19.00)	G....RLVDlCIEELLRHLHSSSR
 1295- 1317 (27.34/12.97)	GpthsWLHD.SLQTLAQVLHSQTR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.07|      16|      23|    1366|    1388|       6
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 1366- 1381 (28.92/10.34)	CA........RLAGLWTSADARST
 1390- 1413 (18.16/13.78)	CAcavncsleALNDFDVIVDAMSA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05404 with Med12 domain of Kingdom Fungi
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