<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05402

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMKGARSMGDLAPGTKSYGSSAPRSAGQPIKPGLPYPPPDMQTTLARPVAGTGAHVPDRQDDRTYIRNGSLQDREAASCAPQRGSAEQRELASPEASTSAVPLGASDESTDLHVLSKDHPTQFGQHLLRSERARKKARLREQPGVSVEALQQELLEETDGLVPLGAIVARLANYGFESFGNLAETLPSLSSSERKSKIFDTALDVRRQLVKLLVLVRWSRAAPDLMMARNLVGLLRAHTIQANDATDALRKMQSELPGARLRKADLVSATDILGTGKYQRLPSHIKDYIVPPRELTDRQALDVISDMDAALRTRLTLSEVVPSPLTCYSIEDGRVTFEVAKLFAASMTLSGNSPEDRWFLLSAKFDFRITGVGADLFPRRPRKRARTILISQADFELAPRSVALASEEDGAAVAAAAVAGGRDAEQFEATHPAPGEQRDECQRRDAPLVRAYNFLQSQALEYQLDILHYQAVELARVGWAPTVSAGFEPILKAGDPRTLTVSYWRKNRSERAGTASRGSAKAAKPVLDPLAGASIKIRAVDRSRRPAKLVALDRALCKDLSAIEAVPGQKLKQQDLVVEWALDPALREHMEDTQLVVNALDLDIEKLLRHAVSLHAAAAVAELRARLSASSLRAAVESPACSSTVTDEGGRSCHLLRLPLHPRLLVVLRIDTMSGRIQLEHSTAASTEAVASTPSNDGMFHRLKEASTQLNDDPTLLVEILQQQRALAILEGFEQKASFLGLHCTRRLPIRSTEYTRLGPETSLLFLPLPQCPNYYVVLRIGDDSVKVGLMCTTAFLDGFNTVLGVHSVEWLDRDRLAKGGALGKRKREEVETGGEPSSELSLEELSLLHHYSVALVCYHQIEQQLRVRGLPFVHVGSASEISSPPARAVALHLTRQDVAKDSTHASMVPSLCVRADHLLGASSSLVRRNVSIELRDWSDPLSCSVKFTVRLRRSLSTSSRKLVLNEATGDVLELESQQSALTFSTRSIDGCVALFLNAWDRVSRIMSLAREVASASRADKLDGLELRSFDLQQVVFAYEGGLTASVSLQDDPQTPRGSSYRLQLASSAGTSQPNPHEVIIDSLSRMLNGRFDGAPTFWPSFLQLLHDTLPYLRVVAPMMDQCLEDVLAPEPDVRSATWLRLTFIDSFVLDVRLLRGSKVLILDGATPLEPSTELQGHGSGSEFLENSSIEKPQDQSSSARRRSNGASHSAALLDGAVSKPIPSFPEILQAVMREFRQRKRTTEAAEAEQHGSTADPKVKFAKPTIRHTSDPAVIHLESGLVCDAMDHLVGPLLSAVIRKIKQRIASELDE
Length1310
PositionTail
OrganismCeraceosorus bombacis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Ceraceosorales> Ceraceosoraceae> Ceraceosorus.
Aromaticity0.05
Grand average of hydropathy-0.242
Instability index52.58
Isoelectric point6.93
Molecular weight143159.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05402
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.03|      35|      64|    1200|    1238|       1
---------------------------------------------------------------------------
 1200- 1238 (53.48/46.26)	RRRSNGAS.HsaaLLDGAVSKPIPSF..PeILQAVMREFRQR
 1266- 1303 (53.55/33.80)	RHTSDPAViH...LESGLVCDAMDHLvgP.LLSAVIRKIKQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.06|      21|      65|     727|     747|       2
---------------------------------------------------------------------------
  727-  747 (36.33/28.32)	AILEGFEQKASFLGLHCTRRL
  775-  792 (22.13/13.76)	YVVLRIGDDSVKVGLMCT...
  794-  811 (30.60/22.45)	AFLDGFN...TVLGVHSVEWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.46|      27|      65|     370|     396|       3
---------------------------------------------------------------------------
  370-  396 (48.21/27.16)	GVGADLFPRR..PRKRARTILISQA.DFEL
  434-  463 (41.25/22.20)	GEQRDECQRRdaPLVRAYNFLQSQAlEYQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.77|      19|      69|    1085|    1103|       4
---------------------------------------------------------------------------
 1085- 1103 (39.86/26.76)	RMLNGR....FDGAPTFWPSF.LQ
 1152- 1175 (24.91/13.53)	RLLRGSkvliLDGATPLEPSTeLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.45|      34|      62|      69|     104|       5
---------------------------------------------------------------------------
   69-  104 (55.03/46.26)	SLQDREAASCAPQRG.SAE..QRELAspEASTSAVPLGA
  129-  165 (48.42/32.60)	SERARKKARLREQPGvSVEalQQELL..EETDGLVPLGA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05402 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPSTELQGHGSGSEFLENSSIEKPQDQSSSARRRSNGASHS
2) MKGARSMGDLAPGTKSYGSSAPRSAGQPIKPGLPYPPPDMQTTLARPVAGTGAHVPDRQDDRTYIRNGSLQDREAASCAPQRGSAEQRELASPEASTSAVPLGASDESTDLHVLSKDHPTQFGQHLLRSERARKKARLREQP
1169
1
1209
142










Molecular Recognition Features






MoRF SequenceStartStop




NANANA