<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05400

Description CDK8 kinase-activating protein cyclin C
SequenceMASDYWLSSQCNHWLFTRSQLITARAEDLRYADSSDDVAAIGIWICNAIAALTKRLSQRQRVTATACIFFRRFYAKIGNSYCSTDPAMVATACFYIAAKIEETPVHVRVVASEAAKLWSELGHPSFPSDVSSLGQMEFYLLEDLDFHLIVHHPYRVLLTFSNNVGKIALSKLDDDFSGSIGMDLNTHTAGKEGLGLGLGMDVESEHARLGDAAKNDGYASTFSDTELKAWEADRAALTKGDDGQPIARLPELDDAALQYAWFVLNDTYRTDIGLLYPPHLIAIAALYLGFTLHQPSRDSLVASAEKMRERRRKWAAAAAALSNPSNQDSESVGGSELAEQYSGSGSGPSAQTPNAHPSSAGSSPIKPSNLVDSPRASTSGSSLGATSAAPRGLASLPARPAHLPAKPGSYHTLSSAGPTSSPRASATGNLLHGTSDTITGQSLGLVSSPAGTLNVDFRLVAEVVQHILAGYEVWHRIDHASTARPEEAPQSHLDDLEDGKEKGATQASTSNGSGTNSVLSDGPAMFAKLHRMRERRRLELNLLNER
Length546
PositionKinase
OrganismCeraceosorus bombacis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Ceraceosorales> Ceraceosoraceae> Ceraceosorus.
Aromaticity0.07
Grand average of hydropathy-0.288
Instability index42.91
Isoelectric point5.88
Molecular weight58588.66
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IEA:InterPro
kinase activity	GO:0016301	IEA:UniProtKB-KW

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05400
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.21|      41|      42|     173|     213|       1
---------------------------------------------------------------------------
  173-  213 (65.80/39.22)	DDDFSGSIG.MDLNTHTAGKEGLGLG.LGMDVESEHARLGDAA
  215-  256 (54.60/31.32)	NDGYASTFSdTELKAWEADRAALTKGdDGQPI.ARLPELDDAA
  265-  304 (58.81/34.29)	NDTYRTDIG.LLYPPHLIAIAALYLG.FTLHQPSRDSLVASA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.10|      40|      45|     324|     365|       2
---------------------------------------------------------------------------
  324-  364 (72.86/38.15)	PSNQ.DS..ESVGGSEL.AEQYSGSGSGPSAQTPnAH.P.........SSAG..SSP
  367-  422 (44.25/15.48)	PSNLvDSprASTSGSSLgATSAAPRGLASLPARP.AHlPakpgsyhtlSSAGptSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.93|      13|      23|      64|      79|       3
---------------------------------------------------------------------------
   64-   79 (19.78/22.94)	ATACIFFRrfyAKIGN
   90-  102 (24.15/15.91)	ATACFYIA...AKIEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05400 with CycC domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DHASTARPEEAPQSHLDDLEDGKEKGATQASTSNGSGTNSVLSDGPAMF
2) KWAAAAAALSNPSNQDSESVGGSELAEQYSGSGSGPSAQTPNAHPSSAGSSPIKPSNLVDSPRASTSGSSLGATSAAPRGLASLPARPAHLPAKPGSYHTLSSAGPTSSPRASATGNLLHGTSDTITGQSLGL
478
313
526
445










Molecular Recognition Features






MoRF SequenceStartStop




NANANA