<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05362

Description "Uncharacterized protein, isoform F"
SequenceMTEELKVVLRRSEQHSGFGFSLLGTTGPPHVIYDIVENSPAADCGAVEAGDVILKVNGTDVHCYTTKEVLKCLRLSDQLVTLELKRDPKLKARIKEQLANTQSPHYVDIESPNIYDYHSSSSTHSSPNHRPAGPGGGKGTATTPTQTGLRYKSPTHLPSLRQNQNQNSSPLQASGSTTTTTTHTHTHTHSRNSSASSTKIKVVEQSITTSTTSSTGIVGPMSPTGGSGGGGGGGGEEATSPTFRPSRIPQARKANAPKPVPVLHSPQHKRPRPSQIPTKASNGTGNGHPAAQPPLQHSNSYSGSPVTRPRFSAEREPDQDREPEPNSAPPQPAKAPRFEAYMMTGDLILNLSRTPQTSNPLPVQTKKVDSLRDSPCRLANPRVNGALAPRASGESSPTSSSSVDSPTNTSSDSMKRDAKMQRKQQKQQPLQQQQQQQQRDSINNSYNRKDSLTNDTLLMCEELERDEEGEYVLDEENRQQAQQQRQQRYIRQQQNQQRYEYYQNEDELEEQEEVEVEEEREEDQTHYGITNIETYQSGMGRGDEDDSDRQCLVDDDDDDEPYDEEENDAGDEDYSTNSVGSGSAKQRLRALKQRTATRHQQRARDAVDCAARSGSGSSSTTVKSEAGGLALDEISFSVPTSPISLSTPLIDKETANSVPTSPEPSSLAPESSSGAGAGAGAGAGVVVRRHNGHVVRKCDAAGFRTSKSEDHLQQIQREGIAAVIPIDIDEDVNSSLNTLLDTRQDSEDSQSMATVIVNNSSSSALNNNELEPNNNTSSSSSGSSSSNSSNNSSSNNNSSSNITNRSATAVATSTIPPATRTTMNCSSKLNYILCKKASDRDRIVWTYNAPLAPHQLAALQRQQQQQEQQFQHQQQQLQQQHLQQQQQLQQQQQLQQQQQQFYGQQSHSNSHSSSISSSVGSPASPTSVSSSVMSSSGSKGALGSSSNGPVALQQQQQREREQGGGQSAVVQPPNGIPGLLSCPGNNGAGGSGLGGGIGVGVHVGGGDQSVSEAISNISSPDYQDDDNLLSSRDILGGMVLSDPSDSDSTILVSDAATLQRQQMKQQLRAQQQRDKERDRDRDQSEHKVVIQVRGLDSNHSNSSGRSDDDVVTLTDEPIGTNPVGLRDGSPPVSDDGSDVESLHSYHYSPKAVDMPSAIRLAKRLHSLDGFKKSDVSRHLSKNNDFSRAVADEYLKHFNFKDKSLDQALREFLQQFSLSGETQERERVLVHFSKRFLDCNPGTFNSQDAVHTLTCAIMLLNTDLHGQNINRKMSCAEFVDNLVDLNDGENFPKDILKYLYQAIKTKPLEWALDEETVDMQQQRANNAALANVGENPFLDPPESATAVEYKKGYVMRKCCYDSNFKKTPFGKRSWKMLYCTLRDLVLYLHKDEHGFGKSQMSDNLHNAIRIHHALATMANDYTKKQHVFRLQTADQAEYLFQTSDSKELQSWIETINYVCAAISAPPLEGGVGSQKRFQRPLLPSKQSKLMLKEQLESHEQQLAQLEQDLNEHKRGPIPSKGLPLQNYKEKESYLQYELRRYRTYVSILSAKLLEDQQQLELQAQKPSPAALEEEADTFPVGTTTPQSIILQQPKEQALKEPQQQQPANRKEKKKK
Length1614
PositionKinase
OrganismDrosophila ananassae (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.908
Instability index63.40
Isoelectric point5.85
Molecular weight177326.48
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
adherens junction	GO:0005912	IEA:EnsemblMetazoa
axon	GO:0030424	IEA:EnsemblMetazoa
cell body	GO:0044297	IEA:EnsemblMetazoa
cell cortex region	GO:0099738	IEA:EnsemblMetazoa
membrane	GO:0016020	IEA:UniProtKB-KW

GO - Biological Function
guanyl-nucleotide exchange factor activity	GO:0005085	IEA:InterPro
microtubule binding	GO:0008017	IEA:EnsemblMetazoa
phospholipid binding	GO:0005543	IEA:InterPro

GO - Biological Process
axoneme assembly	GO:0035082	IEA:EnsemblMetazoa
compound eye morphogenesis	GO:0001745	IEA:EnsemblMetazoa
negative regulation of microtubule polymerization	GO:0031115	IEA:EnsemblMetazoa
regulation of ARF protein signal transduction	GO:0032012	IEA:InterPro
response to alcohol	GO:0097305	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05362
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     101.29|      15|      15|     865|     879|       1
---------------------------------------------------------------------------
  422-  435 (25.17/ 9.19)	RKQQ...KQ.QPLQQQQQ
  480-  494 (26.40/10.01)	QAQQ...QRQQRYIRQQQ
  876-  892 (24.61/ 8.83)	QLQQqhlQQQQQLQ.QQQ
 1059- 1072 (25.11/ 9.15)	QRQQ...MKQQ.LRAQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     155.70|      28|      28|     241|     268|       2
---------------------------------------------------------------------------
  109-  147 (29.79/11.10)	IESP.NiydyH...ssssthssPNHRP...........AG.PGGGKGTATTPTQT
  241-  262 (33.28/13.34)	......................PTFRP...........SRIPQARKANAPKPVPV
  263-  290 (38.30/16.57)	LHSP.Q....H.........krP..RP...........SQIPTKASNGTGNGHPA
  291-  330 (31.54/12.23)	AQPPlQ....HsnsysgspvtrPRFSA...........EREPDQDREPEPNSAPP
  331-  363 (22.78/ 6.58)	.QPA.K....A...........PRFEAymmtgdlilnlSRTPQT..SN...PLPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      97.62|      16|      17|     774|     789|       4
---------------------------------------------------------------------------
  772-  787 (28.11/12.60)	PNNNTSSSSSGSSS.SN
  788-  804 (21.81/ 7.96)	SSNNSSSNNNSSSNiTN
  906-  921 (25.29/10.53)	SHSNSHSSSISSSV.GS
  922-  937 (22.41/ 8.40)	PASPTSVSSSVMSS.SG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.95|      14|      17|     629|     642|       5
---------------------------------------------------------------------------
  629-  642 (26.28/15.14)	LALDEISFSVPTSP
  649-  662 (25.68/14.63)	LIDKETANSVPTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.24|      43|      44|    1214|    1256|       6
---------------------------------------------------------------------------
 1185- 1230 (60.14/36.08)	FSRAVADEYLKHFNFKD..KSLDQALreflqQFSLSGETQERERVLVH
 1231- 1276 (69.14/42.59)	FSKRFLDCNPGTFNSQDAVHTLTCAI..mllNTDLHGQNINRKMSCAE
 1277- 1315 (42.96/23.66)	FVDNLVDLNDGENFPKDILKYLYQAIktkplEWALDEET.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.40|      37|      40|     504|     540|       7
---------------------------------------------------------------------------
  504-  540 (65.29/33.79)	NEDELEEQEEVEVEEERE...EDQTHYGITNIETYQSGMG
  543-  582 (54.10/26.81)	DEDDSDRQCLVDDDDDDEpydEEENDAGDEDYSTNSVGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.61|      28|      29|     155|     182|       8
---------------------------------------------------------------------------
  155-  174 (29.67/13.73)	........THLPSLR....QNQNQNSSPL......QAS
  175-  196 (27.25/11.96)	GSTTTTTT.......hthtHTHSRNSS.........AS
  806-  838 (39.69/21.11)	SATAVATSTIPPATR....TTMN.CSSKLnyilckKAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.41|      27|     631|      37|      63|       9
---------------------------------------------------------------------------
   37-   63 (50.22/37.58)	ENSPAADCGA.VEAGDVILKVNGTDV.HC
  670-  698 (40.19/28.34)	ESSSGAGAGAgAGAGVVVRRHNGHVVrKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.21|      17|      29|    1094|    1113|      10
---------------------------------------------------------------------------
 1094- 1113 (24.20/17.27)	GLdsnHSNSSGRSDD..DVVTL
 1124- 1142 (26.01/11.07)	GL...RDGSPPVSDDgsDVESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.74|      17|      29|     718|     737|      11
---------------------------------------------------------------------------
  718-  737 (22.16/23.32)	EGIAAVIpidIDEDVNSSLN
  750-  766 (27.58/17.66)	QSMATVI...VNNSSSSALN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.95|      34|      40|     963|     999|      12
---------------------------------------------------------------------------
  216-  235 (32.25/ 9.55)	............GIVG........PMSPTG..GSGGGGGGGG
  963-  996 (67.74/37.94)	GGGQSAVVQPPNGIPG........LLSCPGNNGAGGSGLGGG
 1004- 1040 (34.95/13.68)	GGGDQSVSEAISNISSpdyqdddnLLS..SRDILGGMVL...
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05362 with Med12 domain of Kingdom Metazoa
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