<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05359

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSFEGAPPAPAHAHATSSNWASTHISLEPIPWGPLSRDRSSILRDAPRLRDVASAAQETDELLRGGQDEEEEEGAGEDGALLRDTSAAQAAVQRDGLIWDFSSHQAPLSDRVAQLWAARGAFDKLDVGELRKKVHKQDKRKRRRLLRAAQKAGNTVVDEDDDGDEDDEKSKQEKDWGIPPEQEDEKEGDGLLHSRTDEDQKDHAAGTAQSKERQQKTLDPQQVQNLKGPMLAELNYAQESIYSAHCAVSLILLSRPTQISSGSSSTGLGRQGSERGTPLPREREGTATSTRAGAGAGAAAAAAAAGWAGRGVSAAQPGTAMALFEETGLEAEHVSVELLGSFQPDASAQAEDASEGSVYSSSDEGAERSGQNKDRKGVLGKKKERGAEEQEGEEADSLYSAKRNARYLRENDDKLSKEQMEDRTKSLVISAQAARDGILGAIGVLRRGARELDQVCAQKASPTSGSTLTKGLGEGSNVREEGSGATYADRRGTLSAAEREANRWECLARVKSCDWTLSGVANADLDVVLQDEEEAPEREGRAALTTLIEADRNKGARDAWIGWAITEAHADYKQRSLARVHSAEVWSPSAEAAASDAQRKEEMSEKLEQKEESEGRVPAPVSFVYRPNKRLQVSFELSCTGGSLPEQLEARRRDADGQEKVRNMHVDGHGKRRTLFVSSDANVPARWQRSKAGDEASMTRRELNEAQLELADEELFGNLVSEARALSNRGEAHVKITTSSLTIFVSNQVSMLIELIPTRSPQSFDKPTSPTMKDDAAPKGDEVQNIERVASAMPDAILGFLRLGLVGRYKDRACGSSAFGSRRASQGKIEMLHPLLSVLRLLKLRSGVFERVQTLMESFESRTAKSGRVRLEQSAVTFKSFGKKTSKLARAERAEGSEEGGWVSRVFGGRALGAFTSLQSHLALHVDDEMVAVVSTSFPSNITLHLQFPPAPTHLQAAAASNKSAHDPKDDERPESAAQRLDKACDQAGTCIDALGLDTALELLEHEVSRRLRIRD
Length1016
PositionHead
OrganismCeraceosorus bombacis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Ceraceosorales> Ceraceosoraceae> Ceraceosorus.
Aromaticity0.04
Grand average of hydropathy-0.690
Instability index52.14
Isoelectric point5.47
Molecular weight110261.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05359
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     663.76|     182|     189|     116|     304|       1
---------------------------------------------------------------------------
   64-  255 (237.33/101.84)	....................RGGQDEEEEEGAGEDgalLRDTSAAQAAVQRDGliwdfsshqaplsdrvaqlWAARG..AFDKLD.....VGELRKKVHKQDKRKRRRLLRAAQKAGNTVVDED.DDG......DEDDEKSKQEKDWGIPPEQEDEKEGD.GLLHS.RTDEDQKDHAAGTAQSKERQQKTLDPQQVQNLKGPMlaElNYAQESIYSAHCAVSLIL.....LSR
  256-  447 (239.00/104.49)	PTqisSGSSST.GLGrQGSERGTPLPREREGTATS...TRAGAGAGAAAAAAA.................agWAGRGvsAAQPGT.....AMALFEETGLEAEHVSVELLGSFQPDASAQAEDA.SEGsvysssDEGAERSGQNKD.........RKGVL.GKKKE.RGAEEQEGEEADSLYSAKRNARYLRENDDKLSKEQM..E.DRTKSLVISAQAARDGILgaigvLRR
  462-  618 (187.43/74.29)	PT...SGSTLTkGLG.EGSN....VREEGSGATYA...DR..RGTLSAAEREA.................nrWECLA..RVKSCDwtlsgVANADLDVVLQDEEEAPE..REGRAALTTLIEADrNKG......ARD.....AWIGWAITEAHADYKQRSlARVHSaEVWSPSAEAAASDAQRKEEMSEKLEQKEESEGRVP...............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.55|      28|     119|     762|     789|       3
---------------------------------------------------------------------------
  762-  789 (49.33/32.96)	QSFDKPTSPTMKDDAAPKGDEVQNIERV
  879-  906 (47.22/31.17)	KSFGKKTSKLARAERAEGSEEGGWVSRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.46|      16|     940|       7|      22|       4
---------------------------------------------------------------------------
    7-   22 (32.09/19.04)	PPAPAHAHATSSNWAS
  949-  964 (29.37/16.80)	PPAPTHLQAAAASNKS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05359 with Med17 domain of Kingdom Fungi
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