<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05318

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMIEVSVIVNLQKSLFPEDRHACPKTPEVTTVKEKSPERQRVQVISKVGSCKPVYQNLSPTSRPRSPVCDISQTESMTRIQSKDCSRRDFISLSSSKHGLSLTQHRSSLMNNLSWKKGKKSNQRKRKLNGKIEWSNMEPLDVSYLSALAGEDDKDSIDYVFAYSSEWKSHVCMKGEAKSVEFSGKSLATHPTSCQVADNITHAQNTLRSLPLFSQSGSILSSSTTVNLSSGIFVSDCDTQQPSFLDDCNPVSIAVIERRSPVDSVVTDSVHLSPPASNERVEPSQILGGTVANIMARVGGPPSVGDYMIYPTPPSVDATQSQQFSPQNTLLQSNPTIMYPSAVPYMSATAMNLCHNLPLTQLSSSISSESDIITDTGSCVKRDPFFDDNKALGKLYYSINEKPVYSKFMKLELAQSGKFTGNIFAKDFFSFEPKGDRMLEGVYADQFKLITSAVAAREKRKKIGRAPDYLFMRERFRNLIPHSSFSAARHYRMACNSAHLLSLHCMPTSQVLSSGVSMNGLNFGVNGPSFAGNSYNGSSSIMNMMMGGGGCIQSGSNTMVQPITGSSKVGMIHINQQMPIAHLRPSARMPPLPSYAPSQSGIPQHPAFMSHSAQFSGPSAVINASGQICSLSGGTLCPVSTGPTQNIGSSPLQSQHMLSGLHSTTPSQPLGASNFHGSSGGQFPVQQPQQPFQQLSHFVKNANFSGHMGIAPGQPPVEPAPTFSQAVNHQYPPLHSVQSSSIVYSQSPHMLRPNTLITQTHNSNMMNGSRTSQNSLMSMSPSIGSPNSTGLFGNRVMNMPDAAVLTGNVRNYPEGKSLVLAVLLQDTVLDLHYDSVFDACPICSCNGNIRAKEIGVYITPPEVLRQPPAQQQLIVSKPTSGFYNNTSNSCNCGFSAVRHRYLSMKAGLFAEDAKEATDINETQSQPAIPHTIWFDSMSGRDMNFIALLREQTLVRDLGGLLDQVMLLSLQCERASQTEQIGSDSSKRCEYVISEVDQRELPLVFQAACEVACMEMNCRRPPHDIRSVLLHDWGVQMSNEMREPRESECMALLQEIGPILEESLRIARSSPLFGSNNIVEGPLTWRFFDRKALKACGGIEDDSGPEPVPNIVLASEKDAIVTSPQILRLWEKMSLEPYDQPKDVLYIGVVPDNLVCIEKTKKYLMDLSRMYEQCRFGRHIPFIREVLRDGLLRVPTRYPATNPGECDNFLNQVERHIGDNKSLIARLKVYMQYFENEMARILLTNDDVFDREKYRAALAENMFHVVPNSSIASFQCGGYSIPNNPSDQMLPLSMPGNILTSSQSCGTPQGSNNASGPNSAGVTTSNIGESFTPDSSGGDSSGQNISNISSFITEQLTSDGHLPEDETGTLPHVIVIYLVNPFLLGAEENPLVARVVTVALMRAFNALLYRLNNKRRPQLQLELIALQNIFDYCGLSADFLKDERGRLNGYDQGRLEKSQNERLSSSDSLKTIAFSVYTHSRVVLPDIVRGILPKSMTRFGPAAAMVDLLNELDRKDPVYYKVPSKPFILAPPSPVMQRPNCDLMQINTDEVVLFVSYCLIGNDWLAATVTDHQGHLLDNCLINLRLKPDHKRVNMRYKQSTQIRDSLYRLWSYILGILATGTKNWRLVIGRVGRIVWTQILSKPYLKQVGTRMKHVCRACHVMPGTSENPGLLSACLVSLEPEAHLRVFPSSFQHDDRFLKTSRYRTLTTPDDTSCTHILVFPTSPELNLDHQGGSGVAELEEDDFSNLLKENIGEEFNELIGNGEDLMTNTTGSASNAANFRVNGNTGIPSEYADVSIENQPLATGYYISTAPASDLPDWFWSACPAAKRRNPVHLKSSLHLNTPNVQLGDDISSFGKGAEACHHQLDSQATADVLRYVLETYNALSWLNIDLVTGERRSCLPVHIQALMRASKFVEEVRVC
Length1921
PositionMiddle
OrganismThelazia callipaeda (Oriental eyeworm) (Parasitic nematode)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Thelazioidea> Thelaziidae> Thelazia.
Aromaticity0.07
Grand average of hydropathy-0.306
Instability index57.78
Isoelectric point6.60
Molecular weight211720.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05318
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     409.16|     104|     139|     486|     624|       1
---------------------------------------------------------------------------
  276-  342 (68.42/20.19)	...............................................SNERVEPSQILGGtV..ANIMARVGGPPsvgdymIYPT...PPSVDATQSQQFSPQNTLLQSNPT.IMYPSAV....
  512-  624 (180.52/104.90)	SSGVS....MNGLNFGVNGPSFAGNSYNGSSsimnmmmGGGGCIQSGSNTMVQPITGSSK.VGMIHINQQMPIAH......LRPSarMPPLPSYAPSQSGIPQHPAFMSHSAQFSGPSAVINAS
  648-  746 (160.22/63.28)	SSPLQsqhmLSGLHSTTPSQPLGASNFHGSS.......GGQFPVQQPQ....QPFQQLSHfVKNANFSGHMGIAP......GQPP..VEPAPTF..SQAVNHQYPPL..HSVQSS..SIVYSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.10|      21|     372|     976|    1002|       3
---------------------------------------------------------------------------
  976- 1002 (29.41/34.51)	TEQIGSDSSkrceyvISEVDQRELPLV
 1351- 1371 (38.69/26.00)	TEQLTSDGH......LPEDETGTLPHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.25|      30|     464|    1159|    1190|       7
---------------------------------------------------------------------------
 1159- 1190 (52.40/38.55)	KKYLMDL.SRMYEQCRFGRHIPFIREvlRDGLL
 1641- 1671 (53.86/33.64)	KPYLKQVgTRMKHVCRACHVMPGTSE..NPGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.04|      11|     464|     499|     509|       8
---------------------------------------------------------------------------
  499-  509 (22.54/12.39)	LLSLHCMPTSQ
  965-  975 (20.50/10.58)	LLSLQCERASQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     283.27|      90|     931|     843|     940|       9
---------------------------------------------------------------------------
  843-  940 (142.39/122.71)	SCNGNIRAK.EIGVyitPPE.....VLRQPPAQQQLIVSKPTSGFYNNTSNSCNcgfSAVRHRYLSMKAGLF..AEDAKEATDINE.TQSQPAIPHTIwfDSMSGRD
 1775- 1873 (140.87/95.57)	SNAANFRVNgNTGI...PSEyadvsIENQPLATGYYISTAPASDLPDWFWSACP...AAKRRNPVHLKSSLHlnTPNVQLGDDISSfGKGAEACHHQL..DSQATAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.86|      39|     145|     202|     246|      13
---------------------------------------------------------------------------
  202-  246 (55.69/43.12)	AQNTLRSLPLFSQSGSIlSSSTTVNLSSGifvsDCDTQQPsFLDD
  349-  387 (72.17/38.00)	AMNLCHNLPLTQLSSSI.SSESDIITDTG....SCVKRDP.FFDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.80|      15|      15|      36|      50|      14
---------------------------------------------------------------------------
   36-   50 (26.68/15.66)	PERQRVQVISKVGS..C
   52-   68 (24.12/13.36)	PVYQNLSPTSRPRSpvC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05318 with Med13 domain of Kingdom Metazoa
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