<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05305

Description Uncharacterized protein
SequenceMSVSTENMTSASSITAAVGNDAEKLQWIVVNQVEGVQMREMFWDLSKDVDVGELVCNEAVKLLRTMTEEEKAHCCKSSLSLLSNKEEPRYVHYERILSSIFMTACNEGVLSLSDCCELLILSTNFTLTTPMDARKFEYMQKNLHLIDYKGLRNILKLLVVERMQEVPSTITHHHRHMLLPVENMLLTLIDRRLNLLPCLFTITELHRVSSNSRAFLLPRVAKKFNDMFISFRPLTEMVTVIGRSWLYPVATHISFPVSTSSWRLEVTTTRLHQRAHLPYRSELFAPQSSLLYTLLRQPRGKDTISYVMRQNASLTPQRLQCDELLHMIILEAMSEMEKTDTRLDDPANQYQWMNITHTVTFSLLHGNASFSRLLKILNESLSETVYRKGRDELMWVILQYVAVYIDRVSNEEMARVADIYNLLYSDEQTWSGTSHSEVLPKPSESLWRQIQFLQERTADSDPNIQNVADHNAVLAAVANAFSSDMPNFQKLVLTAVDVFLDGSQEEVNTVWHLPHGIISYSKKTPLPLSLIDSLTFHARNHLFQLCLLKLTAMLSVQQTQKLPSPATVDTLVRLAVTTEFEYGVKQVLALLSSTLASVNKNAGLGPAQQDRSRDLLYVLCDILSYRFISYPFPVGSKVNLMLWCYTALGNNQIQMNIALCAALEQVILRFWMWNSPQEMFYLSNAFLGKQGKLASMFNTSNSSYCDPQHGTAAHERQYVNSHVSPELLRCLLLSMFRCLKMTGIEMTTEMIQRCNANFCWPVSVSRVYSSQLTGCTVDDGVADAGMCDELMHRVVQEVHQVQEIIYAQGLAAEDQLLKFFSGERRQTIFCVVYNMLFETKKIHPVVYSVLNSMSNKELTASINKFTDYFVFIFKKSLPSDDQQFAAMIGILNDMVFNLHLISLDRLFTSLVLHPTDDGGTEIAMLIIHSLVGSYSDLHNRITALVHIIPSNKIVNTGAAFFNKMSEYYSQFPELTYREMEAKMRREMQLELGMRPMEQPIVSPELHMPIYYGNIMERILPVVDIILLRAMETVVADQLFTTLLMSFKPCYRYHPQPAAYMYSVLYCLDKTVSHTVRARDFVLEICGQLEDRDGKYALLTPSFISDNHQLSLPSQFCQALVDRILQASNYPHQPPSFAYKDWRFAEMPPVGQALTGACIELLASPHAPSITARSLIDLVFNRPLHQPYATINAVALILTALPLSFQQVFYEHIVSVLDSEALHGDPSACFGSLESECFLLTENQLLTNLALGHAYLQHCNTSSLAALPEFVRDQLAPKLVTEAQLIFVLRLVVPILQRLYDAKERSKQIQDLAVDVYKMTVKVNERVGILKYEDSICDFLYHMKYMYVGDFVKNEAEQAIQRLSPSMRDKLQYISHSQANVTGDLPYKLDPGPSNLLHYIIMEHGDVDLSFSERMKVVRQSTWYWGNMSWRDAEKVLINQLPGTYLVRDSASDRHIFTISYRTESSVHHTRVSQYGGNYCLGGPNSLLKSKSLVSFIEHALQNYGKRKFSMLMHSKSDHTGIELLELNHLLHRHELLPSLKYLCRVVIRNYVDKDLLSYLPLPPNMIRYLQDAKYFVPSCGTMTFNNTILKQRFISMVNPMVMTFEVLKCLKRSCSIFALSSGALPAAISIIRVSGKESRYCLEELTGNRKISPRRLFFANIRWEGELIDQGMAVFLKGPKTATGEDMAEFYVHGSPAVVDCLLNTLAKFDNLRPAKAGEFTRRAFFNGKMTLHDVQSLRHLLAARTQRQRRLALHANSIDEAMEKVRKRLVEIRSVVEAFIDFGDDVEFDWKNIRSSIHLLISDLSSMEKGLYRGTLVINGLSIVILGHTNVGKSSLFNRLVNRDVAIVSDIEGTTRDALEATLHLSSLPVTIVDTAGIRKTPLDAIEAAGIQRTLQRAAEADIVIVVLDSSACGNVEVEVRSVLLHCQLKKDVSVIVVLNKCDLNTVPINSHLSWRIVRTSCTSDVGIDSLFDAVCETIDELCPSANDHVFLSSQQHQLLINKIHRTLSEALKVEDIAIIAELLRDASDYVGEISNLVVNEEILDQIFSSFCIGK
Length2056
PositionTail
OrganismThelazia callipaeda (Oriental eyeworm) (Parasitic nematode)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Thelazioidea> Thelaziidae> Thelazia.
Aromaticity0.08
Grand average of hydropathy-0.019
Instability index44.38
Isoelectric point6.32
Molecular weight233156.63
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GTP binding	GO:0005525	IEA:UniProtKB-KW
GTPase activity	GO:0003924	IEA:InterPro

GO - Biological Process
intracellular signal transduction	GO:0035556	IEA:InterPro
negative regulation of signal transduction	GO:0009968	IEA:UniProtKB-KW
regulation of growth	GO:0040008	IEA:UniProtKB-KW
tRNA modification	GO:0006400	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05305
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.91|      31|      36|    1117|    1151|       1
---------------------------------------------------------------------------
 1088- 1109 (27.56/ 8.68)	LEDR...DGKYALLTPSFISD..NHQL........
 1119- 1151 (52.65/41.59)	LVDRILQASNYPHQPPSFAYK..DWRFAEmpPVGQ
 1153- 1185 (44.70/22.19)	LTGACIELLASPHAPSITARSliDLVFNR..PLHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.18|      21|      34|    1521|    1554|       2
---------------------------------------------------------------------------
 1521- 1543 (32.86/32.03)	IELLELNHLLHRHelLPSLKYL...C
 1556- 1579 (35.32/10.59)	LSYLPLPPNMIRY..LQDAKYFvpsC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.55|      20|      38|    1238|    1257|       3
---------------------------------------------------------------------------
 1238- 1257 (34.66/21.97)	LLTENQLLTNLALGHAYLQH
 1278- 1297 (32.89/20.44)	LVTEAQLIFVLRLVVPILQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.13|      34|      36|     878|     911|       4
---------------------------------------------------------------------------
  130-  159 (42.03/25.07)	PMDARKFEYMQK..........NLHLIdykGLRNILKLLV
  878-  911 (59.70/38.94)	PSDDQQFAAMIGILNDMV...FNLHLI...SLDRLFTSLV
  914-  945 (43.41/26.15)	PTDDGGTEIAMLIIHSLVgsySDLH.......NRI.TALV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.14|      25|      34|    1427|    1451|       6
---------------------------------------------------------------------------
 1427- 1451 (43.76/27.70)	MSWRDAEKV...LINQLPGTYLVRDSAS
 1458- 1485 (40.38/24.97)	ISYRTESSVhhtRVSQYGGNYCLGGPNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.65|      12|      34|     993|    1005|       8
---------------------------------------------------------------------------
  993- 1005 (18.78/16.35)	MRPMEqPIVSPEL
 1027- 1038 (19.87/11.38)	LRAME.TVVADQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.50|      33|      34|     522|     555|       9
---------------------------------------------------------------------------
  522-  555 (52.28/39.39)	KKTPLPlSLIDSLTFHARNHLFQLCLLKLTAMLS
  560-  592 (53.23/35.34)	QKLPSP.ATVDTLVRLAVTTEFEYGVKQVLALLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.68|      18|      21|      56|      73|      10
---------------------------------------------------------------------------
   56-   73 (29.96/23.07)	CNEAVKLLRTMTEEEKAH
   75-   92 (30.72/23.88)	CKSSLSLLSNKEEPRYVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.09|      12|      21|    1851|    1862|      11
---------------------------------------------------------------------------
 1851- 1862 (19.63/12.99)	DIEGTTRDALEA
 1875- 1886 (20.46/13.87)	DTAGIRKTPLDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.49|      14|      21|    1938|    1952|      12
---------------------------------------------------------------------------
 1938- 1952 (20.12/16.06)	VVLNKCdLNTVPINS
 1958- 1971 (24.37/14.13)	IVRTSC.TSDVGIDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.85|      20|      21|     387|     406|      13
---------------------------------------------------------------------------
  387-  406 (35.42/22.61)	RKGRDELMWVILQYVAVYID
  407-  426 (33.43/20.93)	RVSNEEMARVADIYNLLYSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.55|      21|      23|    1362|    1384|      14
---------------------------------------------------------------------------
 1362- 1384 (32.31/26.65)	LSPSMRDKLQYISHSQANVtgDL
 1388- 1408 (39.24/25.13)	LDPGPSNLLHYIIMEHGDV..DL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.82|      12|      15|     240|     251|      15
---------------------------------------------------------------------------
  240-  251 (23.66/12.73)	VIGRSWLYPVAT
  257-  268 (20.16/ 9.78)	VSTSSWRLEVTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     495.62|     164|     969|     622|     807|      19
---------------------------------------------------------------------------
  622-  807 (257.13/231.71)	ILSYRFISYPFPVGSKVNlMLWCYT......ALGNNqiqmniALCAALEqvIL.......RFWMWN.......SPQEMFYlsnAFLGKQGKLasmFNTSNSSYCDPQHGTAAHERQYVNSHVSPELLrcLL..LSMFRCLKMTgieMTTEMIQRcnANFCWPVSVSRVYS.SQLTGCTVDDG...VADAGMCDELMHRVVQEVHQVQEIIYA
 1588- 1779 (238.48/164.94)	ILKQRFISMVNPMVMTFE.VLKCLKrscsifALSSG......ALPAAIS..IIrvsgkesRYCLEEltgnrkiSPRRLFF...ANIRWEGEL...IDQGMAVFLKGPKTATGEDMAEFYVHGSPAVVdcLLntLAKFDNLRPA...KAGEFTRR..AFFNGKMTLHDVQSlRHLLAARTQRQrrlALHANSIDEAMEKVRKRLVEIRSVVEA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05305 with Med23 domain of Kingdom Metazoa
Unable to open file!