<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05300

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMGDDDWPSQRFRDHVISRLEPELARNRQNAPNLPVPGDARQVEEYVFNKCVSKDEYMRTIAKVINAINCNSKAAAVPSFLQTSHMPSTTQNYQTVPGSSIPPDPQPTHQQQQRIMERYHAPLLGQPPPMIHSQQSSPGAVSVSNGSMLPAQSVMQPSPVAQSGVSQQSPYNMLSPVPSVPGPQSSSPSHQMYNHVKSEPKGSNGMPGTAEVPLSDAMPLNMWKREAFPSNSYYLAGTCGVVSSGQYVERTHLSAPFGTSVPCSQNRKASPQQQQPSVLENLINSPHYGSPTLSPGHLNGSGNQNVADAPSGNAVQPNEERLYTEKLRSLRPYAETLRARAQQCLLEGNEVVASKFDTMCNVLDGKSRVSYEYLLQIEAWIYKKQEFLQLSLNVGPSQPQPLVDAVNAVLLNTETQAGYTDRIQTNTAVPSVTHWPLSASQPPQHQQTSQILPSMVPSVVSISSLQDTMMQSSVPLQSTCQQLARHSMEHTYQRHAPYPNPNAAVRSSSQMQSIMLHRGSVKVQQARTPAASLSSFSESSRIPTIDCSAVDDLYVMDDFLPTPIEAVTNSTLPQMESQLPEVVYQELLALGDRFVADSSIEEIPDSHSFIVKFTLTSHNVPPLRLIIPKAYPNGEVLVGRGALDLVISPDSFFFDDLQNVVHERLARPGLRTVTDFLEVWESTVRGYYMGQHQQSLLPNSFDDILQSTNFGDFLS
Length714
PositionTail
OrganismThelazia callipaeda (Oriental eyeworm) (Parasitic nematode)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Thelazioidea> Thelaziidae> Thelazia.
Aromaticity0.07
Grand average of hydropathy-0.440
Instability index63.14
Isoelectric point5.73
Molecular weight78567.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05300
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.22|      44|      44|     443|     486|       1
---------------------------------------------------------------------------
  443-  486 (75.70/38.72)	QHQQTSQILPSMVPSVVSISSLQDTMM.QSSVPLQSTCQQLARHS
  489-  533 (71.52/36.21)	HTYQRHAPYPNPNAAVRSSSQMQSIMLhRGSVKVQQARTPAASLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     251.65|      46|      48|     133|     178|       2
---------------------------------------------------------------------------
   81-  128 (63.08/26.24)	.QTSHMPSTTQNYQTVPGSSIppdPQPTHQQQQRIMERYHAPLLG..QPPP
  133-  178 (76.63/33.46)	QQSSPGAVSVSNGSMLPAQSV...MQPSPVAQSGVSQQSPYNMLS..PVPS
  183-  229 (69.76/29.80)	QSSSPSHQMYNHVKSEPKGSN...GMPG.TAEVPLSDAMPLNMWKreAFPS
  245-  275 (42.18/15.10)	QYVERTHLSAPFGTSVPCSQN...RKASP......QQQQP...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.53|      19|      44|     590|     608|       3
---------------------------------------------------------------------------
  590-  608 (33.91/20.98)	GDRFVADSSIEEI..PDSHSF
  633-  653 (28.62/16.62)	GEVLVGRGALDLVisPDSFFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.07|      16|      16|     541|     556|       4
---------------------------------------------------------------------------
  544-  561 (24.11/15.00)	IDCSAVDDLYVMDdfLPT
  563-  580 (21.96/13.00)	IEAVTNSTLPQMEsqLPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05300 with Med15 domain of Kingdom Metazoa
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