<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05291

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMATLEDEDWPSQKFRDHVIQRLEPELQRNRQHAPNLPVPGNAREVEDYVFQKCTSKDEYMRTIAKVINAINCNSKSSSMPSVLSNHYNKNGLSPTTGNNPPSNIPPDPQPTQQSDIPLSVVGSGNVTTNTEVPSSRQLNQVSSSGVPIQRQSPLPSNNNITSHTPPVSGGIQQPSSGNSGFPNTQQQINSSTGYGSQIPQNMSQPQFMRNSQQIKNEYNGINEQVSYGIPQVNSMYPQTMNKPSMPTEDMMSGNPMIQRQRGWNVQQDNGQYMQNPMIQVPQPNMGMGQPMMQYINQQQPYTEYAYQNSTIPINNSMNFSNNCLPIQNEKMYEGKLKDLRQHANMIKGKANYYRSSGNPTAASRLDYIYEVLIGEKKPPYETIMKIEEEINKILLSQNIMVSNIGMSSQIGGPIMQEPKLLQQQYYSQPQWMGPQQISGMNSGPSPYSVTGANPMPHQQYNVPTSPSGSQQQQSLRHSPYQIPNKHSQGNYTSRQSSLPHSKTQSQPTNINTYQNNFHYPSQSLTTTITNNGSTLEELYSTSYDQMLGSKSGTVDEINSLYGQQQQSQNNPPNFTTYLTSNMNQEINTLKSQFTFKNICGTYDGNYINVDVVFNNFEKDFPPFRLVIPKTYPAVPVSFEQLPLDIESFLYEEVQSHMYSEIRKKNPKTITDILKIAESAALDFYSKQQCNQINTPGLDDIFRSSQYDSALQ
Length711
PositionTail
OrganismStrongyloides papillosus (Intestinal threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.08
Grand average of hydropathy-0.861
Instability index64.00
Isoelectric point6.16
Molecular weight80076.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05291
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.33|      18|      18|     446|     463|       1
---------------------------------------------------------------------------
  446-  463 (34.35/14.87)	PYSVTGANPMPHQQYNVP
  466-  483 (32.05/13.38)	PSGSQQQQSLRHSPYQIP
  499-  513 (21.93/ 6.82)	PHSKTQSQPTNINTY...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     347.70|      79|      80|      91|     169|       2
---------------------------------------------------------------------------
   75-  107 (35.50/ 6.59)	...........................................KSSSMPS...VLSNHYN.....KN.............GL.SPTTGNN..PPSNIP.PD
  108-  189 (120.47/39.15)	PQPTQQSDIPLSVVGSGNVTTNTEVPSSRQ.LNQVSSSGVPIQRQSPLPSN.NNITSHTPP...VSG.............GIqQPSSGNSgfPNTQQQ.IN
  190-  284 (106.69/33.87)	SSTGYGSQIPQNMSQPQFMRNSQQIKNEYNgINEQVSYGIP.QVNSMYPQT.MNKPS.MPTedmMSGnpmiqrqrgwnvqQD.NGQYMQN..PMIQVPqPN
  288-  348 (85.03/25.57)	GQPMMQY.INQQQPYTEYAYQNSTIPINNS.MN.FSNNCLPIQNEKMYEGKlKDLRQHANM...IKG..................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.91|      20|      24|     566|     589|       3
---------------------------------------------------------------------------
  526-  544 (28.02/12.85)	TTITN..N.GSTLEEL.....YST....SYD
  545-  575 (16.48/15.23)	QMLGSksGTVDEINSLygqqqQSQnnppNFT
  576-  594 (34.41/17.63)	TYLTS..NMNQEINTL.....KSQ.....FT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.58|      16|      25|     609|     631|       4
---------------------------------------------------------------------------
  606-  623 (26.28/25.71)	YinVDVVFNNFEKDFPPF
  631-  648 (24.30/ 7.54)	YpaVPVSFEQLPLDIESF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.45|      31|     318|      39|      71|       5
---------------------------------------------------------------------------
   39-   71 (46.16/33.59)	PGNAREVeDYVFQK..CTSKDEYmRTIAKVINAIN
  359-  391 (50.29/27.83)	PTAASRL.DYIYEVliGEKKPPY.ETIMKIEEEIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.66|      18|      25|     657|     674|       7
---------------------------------------------------------------------------
  657-  674 (30.59/16.18)	MYS..EIRKKNPKTITDILK
  683-  702 (29.06/15.04)	FYSkqQCNQINTPGLDDIFR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05291 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MATLEDEDWPSQKFRDHVIQRLEPELQRNRQHAPNLPVPGNAREVEDYVFQ
2) SSMPSVLSNHYNKNGLSPTTGNNPPSNIPPDPQPTQQSDIPLSVVGSGNVTTNTEVPSSRQLNQVSSSGVPIQRQSPLPSNNNITSHTPPVSGGIQQPSSGNSGFPNTQQQINSSTGYGSQIPQNMSQPQFMRNSQQIKNEYNGINEQVSYGIPQVNSMYPQTMNKPSMPTEDMMSGNPMIQRQRGWNVQQDNGQYMQNPMIQVPQPNMG
3) WMGPQQISGMNSGPSPYSVTGANPMPHQQYNVPTSPSGSQQQQSLRHSPYQIPNKHSQGNYTSRQSSLPHSKTQSQPTNINTYQNNFHYPSQSLTTTITNNGSTL
1
77
431
51
286
535










Molecular Recognition Features






MoRF SequenceStartStop




NANANA