<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05289

Description Uncharacterized protein
SequenceMFNSTKSYKVPNWNTESTEKRPIRKASRGKHFDIFPQDSKQDEDNLSSHDRIRKGYLYPQHSYEHESLIYNQKTSKIDAKLDDTIKKANNFFITVMKKRSNDNPKSGKRPLVAKAFQVSEWNFLTKIPRCPSIPQFFEDLSKGKALYGLIRRFPQFEKNEDFLKYLFDYRVPIVRAIWFIKMVAIFKATHIPVVTKPPKKSQALQSALEYVQSLISGLIIHTFNNFYNKDKSEDEKNDRWNYFSLLIKHMCEEGVLDRQDFLTDMIDLLNKYQNYPLDKPQRFKILFLFVSQFIHYVTQNIIISRRMAFIICRRFQKYHYDYMNVAGKPITAGEALSEISKCENHRAIINNMTGMLYSIITECPQSLPRKYMIYVKKFTGIKIYDELGGSPLDELTCPFDTMCREGNLLPQNMIEIMKPKIQEIIDRSIDMKYQWHEVISGKTYCSEVIRMILKMYETLDNVFLLNDKEIVNLHEDIFKNTMNMDDEIEVVLRRRMLIHWSVTSQRDGTHRVSLVVRLLQVHLKDIKDKCGIMINILNDYIYSEAPKLGYCNYGYEFRNFILLLNDLQLYGIIEYKKLLDYWIKKGRIEIDNCLWAKTVKYIYGENYERDFHPSWNKNISMSSRYALQFYRRDSEKHTLLNLEGVTPEERIILQLPIIPSIQNREDIHFHDRLMFGISIQKNEHVNYIKEVARGIIKVWKKLYYFKVDINKSNVHFHEYHDIVRYKNCGDILRRFRRQTYYDQTLITYWVGDNFKEYIVNFIENTNSVLPGLDGLDYILRMFCISMNIGGMINYILEILPKISKLEDIMLGRCYNFIPGVITKGYAFVIVAYLSEHLMYFLNHPNTIGVLNGLYQTIENTIKLQGYPRTSYDSSISVFVSQCKYYLLVHGIAKPNDVMGCAEDFEKLYPRKSIETKIEQPRVQPKKHFFAKYLNSSPTLLPFNEIRSLIKGVNSNGISCRISFVLSAINIVKTLGRRVNKISAIANYCANVSALLNLESEWISAIVELCSITNNPHSMYRGVHKIFNVSRTTTHYALSTFVAILAARFTFRPHELIKKLIKSSLIYAFRGAYNRSKYGYQKVILSALICTKIVTGYHDPFKLPRGYSGLAEVKRPIVKKLSDFKACNVLFPRELDSVIFPLIKIFTMINRPMRKIRRNRAPKKIRVSHFLRACLLFISEQHWFYQKMHFGILNRSGDWEQFKKFLLKNFGLPGILLNYISRRKGDRRAKLMNIGCAENSSKKAYIERSLSSLNVWNFKAVFWDLWGIMMDGTRRPQMKNYPQRIYHCEQLVTEIAKGISDIFTNISNSFKRHVDFKTDTRFRLEEVKNSYLIEDLVMMFPKIWLPRTRSAYYKMQVTTLPSAVLKEFTYIITSTYSKTNYALRMEQMSHLLHITPFLRILQTICNSEPPQTSYALLQGLYGYLSSLIDDFDSRRLLRSSLISDKEGLILRVVMIAGMMDQLLTMEKIEPWAVLFWQLLYYEVFHPEREGKYYNICYDALTNVLFNSAFKFQSRHIHIEHAYYRARYLTYMQLCKRLKKEGQDRPFSADKQQLSQLLPLPKRTFDYISFDHYFKMVGKARNAYTVNSSSSNEMKLINRTGYYPVEKIKLTTFETVQSFFHELLGKRTVNYSFYSAVLADYVPKVSIDLLIRLSFHDHYRLFPRAPIIGEGKELIKDFMYRHPEVEITALPKEDKEKEKIKLMPPRPLMNPSISTNPTIASNPQIAAILSHTSDKSVSSPGGIIKDSNIPIDVKQSLSDMPKITKEVIHDINPRSTPKNVPNPINALQNKPPNLIDQVSHSIDMPNQSSSISKHRNESPIKNEIMSQQIQKNSIQQQSLHNRHLPPNGQQQLIQPTLSNVNKPPPPYNSSQHPMQKPFSSQDVRMGMPSSDVSGSNINQNKIHFNDESTYSRDMSQQEHMQIDSQPPLLVASGNLSKGNKRKPHPGTGSSMKTVAKKRKDNKGNDLLSPPNLLENQPTLGQHGQQPIGMRTFDNNQQNQQLPNFGNQGNFGSQGNIGMSQNMPHKNNIPNQGNIPNQGGIHGQGSIHNQSNIHNQGSLPNKSTMYNQGNVSQQSNLHEQGNHLNQNPHHQSQGIHQSQSNHLPQSTPHQQHQTSQLNQGPNNIGMGQQPQSGNMFINNSGPTKVQQQNQPSSRLPQQNVNSMNMGRNQQSGSMNVLSHQQPPSMNHPSHPQQQQSTLNMVGNQKSTTINVGSHQQQGNIMGMSNPQHGNVSNSQMSNMNISCHSQNSSGGRSNHPPQQPPPPYNMSTMGQQQSSSMNVPNAQQQSNSMPIQSGMGGSSISISSNQQRNMISMSDGRVNNPINISGNQQNTNISMSSSQQNMPMNMQTNQQQSSGMGKSNILQQVLNNPNSTQNIPQTQQYNKNIGITGNPQQQGNIQSQQQQQKSMIPPSNQQSNIPPHIQQNISSGMRQQPQQTAPPMQQGVNQKMYGQSGSGMTKPMGKNMMGLGMKPQNLPGPQPHQQQQSQQTSGSSMMSNMGNTMSGGMSSNMSSSSNMVNNLSSNMSSGTMHSNMSNQQRMMHQNMMNQQSQQQQVPQSRQIQESGISMGQQQQQRPQQIGNSQQQMSGTQGHMSGQRGQIHNPQQPPLSGMQQQMSGHHQQIPPSHQQQMHNQSQQSHSSQQQVGNPQQIMGNPNQSMMSTSQQQWNLQHPQQGSMGKEMQGMNAGRMPPMNPGMVRDRGNIRAGSEAPLEDTKKILKDMLKQKTNPGPVLHLSNQQHQQNMIVNQQGPSQHQHMGMSGQMQHNQGSIMNTYETNQRQEMLYRNSQQHPNVSMGMINQQQPQQGSQTQQQYNSQQMYP
Length2813
PositionKinase
OrganismStrongyloides papillosus (Intestinal threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.08
Grand average of hydropathy-0.654
Instability index58.73
Isoelectric point9.59
Molecular weight322970.09
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05289
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     216.33|      21|      21|    2070|    2090|       1
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 2024- 2047 (25.77/ 7.41)	NNIPNQ..GNIPNQGGIHGQG.sihNQ
 2048- 2071 (23.85/ 6.06)	SNIHNQ..GS.LPNKSTMYNQgnvsQQ
 2072- 2090 (31.21/11.23)	SNLHEQ..GNHLNQNPHHQSQ......
 2175- 2192 (30.37/10.64)	S..HQQ..PPSMNHPSHPQQQ.....Q
 2380- 2400 (25.35/ 7.11)	KNIGIT..GNPQQQGNIQSQQ....QQ
 2469- 2488 (24.75/ 6.69)	QNLPGP..QPHQQQQSQ.QTS....GS
 2527- 2547 (29.56/10.07)	SNMSNQ..QRMMHQNMMNQQS....QQ
 2611- 2632 (25.46/ 7.19)	SGHHQQipPSH.QQQMHNQSQ....QS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     738.75|      85|     103|    2153|    2255|       2
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 1719- 1820 (61.98/20.03)	.SN.................PQI.A...A...IL.........SHTSDKSVS..................................SPGGiikDSN..IP..I..DvkqslsdmpkitkevihdinprstP.K.....................NVP.N.PI...NALQNK....PPNL.ID.....................qvshSID..M.PNQ.......................SSS...ISK.................HRNESPIKN
 1823- 1911 (73.45/25.38)	MSQqiqknsiqqqslhnrhlPPN.G...QqqlIQP........T.LSNVNKPPPPY..N...........................S.......SQ..HP..M..Q.....................kpfS.S.....................QDV...RM...GMPSSD....VSGS..NI..........................N......Q.......................NKIHFNDES.................TYSR....D
 1912- 1986 (73.27/25.29)	MSQ.................QEH.........................MQIDSQPPllV...........................ASGN...LSK..GN..K..R.......................kP.H.....................PGTgS.SMktvAKKRKD....NKGN..DLL..................S....PPN..LLENQ.......................PT....LGQ.................HGQQP..IG
 2153- 2219 (64.34/21.13)	..................................................................................................................................P.Q.....................QNV.N.SM...NMGRNQ....QSGS.MNVLshqqppsmnhpshpqqqqS....TLN..MVGNQ.......................KSTTINVGS.................HQQQGNIMG
 2220- 2287 (123.00/48.48)	MSN.................PQH.G...N...VSN........SQMSNMNISCHSQ..N...........................SSGG...RSN..HP..P..Q.......................qP.P.....................PPY.N.MS...TMGQ.Q....QSSS.M............................N....................................VPN.................AQQQSNSMP
 2288- 2354 (76.00/26.56)	IQS.................GMG.GssiS...ISS........NQQRNM.IS.MSD.................................G...RVN..NPinI..S........................GnQ.....................QNT.N..I...SMSSSQ....QNMP.M............................N..MQTN...................................................QQQSSGMG
 2355- 2463 (57.69/18.03)	KSN.................ILQ.....Q...VLN........NPNSTQNIPQTQQ.yNknigitgnpqqqgniqsqqqqqksmipPSNQ...QSN..IP..PhiQ..............qnissgmrqqP.Q.....................QTA.P.PM...QQGVNQkmygQSGSgM..............................................................TKPMG..................K....NMMG
 2494- 2569 (52.16/15.45)	MGN.................TMS.G...G...MSS......nmSSSSNM.VNNLSS..N...........................MSSG....TM..H..................................snmsnqqrmmhqnmmnqqsqqQQV.P.Q......SRQI....QE.........................S....GIS..M..................................GQ.................QQQQ.....
 2570- 2647 (64.05/20.99)	..R.................PQQiG...N....SQ........QQMSGT..QGH................................MSGQ...RGQ.iH......N........................P.Q.....................QPP.L.S......GMQQ....Q.........................................msghhqqippshqqqmhnqsqqsHSSQQQVGN.................PQQ...IMG
 2648- 2727 (57.65/18.01)	..N.................PNQ.S...M...MST........SQ.QQWNL............................................Q..H...P..Q.....................qgsM.G.....................KEM.Q.GM...NAGR...........M.....................P....PMNpgMVRDR.......................GN..IRAGSeapledtkkilkdmlkqKTNPGPVLH
 2728- 2794 (35.18/ 7.53)	LSN.................QQH.Q........QNmivnqqgpSQHQHMGMSGQMQ..H...........................NQGS...IMNtyET..N..Q................rqemlyrnS.Q.....................QHP.NvSM...GM.INQ....Q...................................................................................................
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.00|      23|      35|    2091|    2114|       3
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 2091- 2114 (42.35/21.07)	GiHQSQSNHL..PQSTP...HQQHQ.TSQL
 2124- 2152 (29.65/ 9.87)	G.QQPQSGNMfiNNSGPtkvQQQNQpSSRL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     294.13|      98|     104|     585|     688|       4
---------------------------------------------------------------------------
  564-  634 (71.55/58.22)	....................................LNDLQLYGI.IEYKKLLDYwI...kKGRIEIdnclWAKTvkYIYGENYER...DFHPSWNKNISMSSRYALQFYRRDS
  635-  739 (161.54/106.71)	EKHTLLNL.EGVTPEERIILQLPIIPSIQNRED.IHFHDRLMFGISIQKNEHVNY.IkevaRGIIKV....WKKL..YYFKVDINKsnvHFHEYHDIVRYKNCGDILRRFRRQT
  741-  795 (61.04/33.16)	YDQTLITYwVGDNFKEYIVNFIENTNSVLPGLDgLDYILR.MFCISMNIGGMINY.I.........................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.00|      16|     146|     250|     269|       5
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  250-  269 (24.92/22.82)	MCEEGVLDRQdfltDMIDLL
  402-  417 (32.08/18.02)	MCREGNLLPQ....NMIEIM
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.14|      36|      41|     858|     893|       6
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  817-  855 (37.15/19.06)	.....IPGVITKGYAFVIVAYLSEHLMYFLNHpntigvlnGLYQ
  858-  893 (63.22/38.03)	ENTIKLQGYPRTSYDSSISVFVSQCKYYLLVH........GIAK
  902-  931 (50.76/28.97)	EDFEKL..YPRKSIETKIEQPRVQPKK....H........FFAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.11|      19|      35|    1364|    1382|       7
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 1364- 1382 (32.75/21.18)	LKEFTYIITSTYSKTNYAL
 1397- 1415 (34.36/22.65)	LRILQTICNSEPPQTSYAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.33|      21|     146|     149|     169|       8
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  149-  169 (39.33/24.97)	LIRRFPQFEKNEDFLKYLFDY
  302-  322 (41.00/26.37)	IISRRMAFIICRRFQKYHYDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.75|      43|      43|    1623|    1665|      10
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 1576- 1622 (47.68/33.75)	GKarnaYTVNSSSSNEMkLINrtgYYP...VE.KIKLTT.FETVQSFFHELL
 1623- 1665 (73.17/56.92)	GK....RTVNYSFYSAV.LAD...YVPKVSIDLLIRLSF.HDHYRLFPRAPI
 1669- 1706 (55.90/41.22)	GK....ELIKDFMYRH..........PEVEITALPKEDKeKEKIKLMPPRPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.81|      19|      43|    1162|    1180|      13
---------------------------------------------------------------------------
 1119- 1134 (16.18/ 7.62)	...KLSDF..KACnVL.FPREL
 1162- 1180 (34.19/25.53)	KKIRVSHF.LRAC.LL.FISEQ
 1202- 1222 (22.44/13.84)	KKFLLKNFgLPGI.LLnYISRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.93|      28|      42|     953|     981|      14
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  953-  981 (42.66/34.84)	NSNGISCRISFVlSAINIVKTLGRRVNKI
  998- 1025 (51.27/37.26)	ESEWISAIVELC.SITNNPHSMYRGVHKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.99|      14|      41|    1479|    1495|      15
---------------------------------------------------------------------------
 1479- 1492 (27.41/24.97)	YYEVFHPEREGKYY
 1509- 1522 (26.58/12.15)	KFQSRHIHIEHAYY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05289 with Med12 domain of Kingdom Metazoa
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