<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05288

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDGSNFSDDSSSDGKEEFARFSSDKFTDNIKRNWSLEKEFSRNNNKHDEEFEEILSYLPSVPQSHNSGMIPFGSLLQFASHKISQELIVLSELIPKAYDQSKKISLVEFSFVAMNLFSKILAILKWYRYFKKYRLCTPIQYFLDQQSQIFRDTADALYTIAKVELRGARLPYFEMEAALNNIWQNFNCLPLAIKKRFIPDPPVSKIDQKIILSRLNHVLKNRLSLISTKIPIVITDITIRNGTVSLKVNGEYETVLTLLSSDVSEKWTLLHIKILVEQHDIGYGTTLVHPLQLHNVHQHLQKLMNESDNPINTLHDFMHKFCLSLQLDVIFCEATQLIQNQYNRKLIIEKYDMDGGKLIISYWPKYNGKKISPSQYKLIITHSKSTSFHGLRVYHMPYKSNMPQLDTNTGRLSLNTLIGTTTAIRAKEKLQILRKKLNKINPIAGTFISGELLQIIKFPLLDDTNISEDEYLYFTVNRFTGAYFCSFKYDDSDENINKLSETLNNNGHVNEIQRLINNIRVNFLMKKYKEIISLNYLIVSEAILPEKAREFLKDKEKDRICIKFHQDLPYYCIFFFTKHISNGISISQYIVFKNNNDEVLIFPFNDVIQESKEEDIESNINTKLLFRNSSNPPKISHLSSEIKNLILVMDMKVRHLRLTEDFKKKGIAVEPINHEKPNDPIKLKINFIPFLQPKDLEFLNNIKNLLVFCDNRAKLLWPFEFYIQNIPIIADFCKHTLLEDISTKHCGKRNFILSSRTSSSMACTSASLDIVSTNFIEKIAICTMIYKQVFHFSKYYYAYYRKFCNIKIFNFQKLIIAYGKNRDQLMFLTYKPSRKTYIMSFGVGSPKNFVNGVNDVYQSSNQTYINIHNSVSLYIHEMTRKEYFLRDVIHYLVNTTDALTYLYRSIKPKFISTEAFGQISRETIFHNQEFQFELFIVDEHSFRLSNGIFSLGIYVYDINFVYIKDCSYGEPSLIGLQNFLKVQTQNAASKSLNQMNSVERNTYFTTSRKVYRLSLSAFERLTALNTVDNNYSVIGKYLINLRSFDKLRIIFSQQKEKTISKGCNIRFSDFQRTSFYTKVTFQGATLPNGTIPCTIHFTVYLEPNTFDLKAKIEYEGSFKPSESEIKMAEKYFEKVLSNGNCPQGVYSFMNILRLTYPMSFANLTLLMELEMKPPSNHYYRLSLDLVSNDHRNSDQTVQYSPSFLIDEKSFRVLVPVSLRPQKRESKDSKCIDPDRLKLNAVWDIKNNRLNLHKPATDLMKFINDKITKHNEIAKENNDCVIESCIKILLIHQLKEPVVIT
Length1301
PositionTail
OrganismStrongyloides papillosus (Intestinal threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.12
Grand average of hydropathy-0.291
Instability index37.13
Isoelectric point9.03
Molecular weight151519.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05288
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.67|      17|      25|     816|     839|       1
---------------------------------------------------------------------------
  818-  839 (27.40/32.26)	AYG....KNrdqlmFL.....TYKPSRKTYI
  841-  866 (21.27/ 6.31)	SFGvgspKN.....FVngvndVYQSSNQTYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.96|      18|      21|     691|     710|       2
---------------------------------------------------------------------------
  691-  710 (28.84/20.44)	FLQPkdLEF.LNNIKNLLVFC
  716-  734 (32.11/16.65)	LLWP..FEFyIQNIPIIADFC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.17|      15|      23|     342|     363|       3
---------------------------------------------------------------------------
  342-  361 (20.90/32.48)	QYN.RKLIIEKYdmdggKLII
  366-  381 (23.27/ 9.43)	KYNgKKISPSQY.....KLII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.00|      10|      21|     783|     795|       4
---------------------------------------------------------------------------
  783-  795 (15.32/18.71)	CTMiykQVFHFSK
  805-  814 (19.68/11.72)	CNI...KIFNFQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.50|      20|      23|    1000|    1022|       5
---------------------------------------------------------------------------
 1000- 1022 (24.99/21.96)	ErNTYFTTSRkvYRLSLSAFERL
 1029- 1048 (34.51/18.55)	D.NNYSVIGK..YLINLRSFDKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.54|      20|      23|     416|     438|       6
---------------------------------------------------------------------------
  416-  438 (27.06/24.78)	N...TLIGTTTairAKEKLQILRKKL
  439-  461 (29.49/18.10)	NkinPIAGTFI...SGELLQIIKFPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.31|      19|      26|     552|     577|       7
---------------------------------------------------------------------------
  524-  546 (27.25/ 8.60)	FLMKKYKEIISLNYlivsEAILP
  552-  570 (35.06/34.75)	FLKDKEKDRICIKF....HQDLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.10|      57|     549|     576|     687|       8
---------------------------------------------------------------------------
   27-   86 (92.75/39.56)	FTDNIKRNWSLEKEFSRNNNkHDEEFeeILSYLPSVPQSHNSGM...IPFGSLLQFASH..KISQ
  577-  638 (86.35/137.24)	FTKHISNGISISQYIVFKNN.NDEVL..IFPFNDVIQESKEEDIesnINTKLLFRNSSNppKISH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.97|      12|     266|     928|     944|      12
---------------------------------------------------------------------------
  928-  939 (21.12/23.57)	NQEFQFELFIVD
  947-  958 (20.85/ 6.17)	NGIFSLGIYVYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.61|      13|      28|      95|     107|      14
---------------------------------------------------------------------------
   95-  107 (22.79/12.68)	IPKAYDQSKKISL
  124-  136 (25.82/15.33)	ILKWYRYFKKYRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05288 with Med14 domain of Kingdom Metazoa
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