<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05286

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMDQNQGTINVSPFPFPPEYAQEYTTENIKSGRFRYPPPIPKKYKLFGIEYDRDNDKEPSLLDLKIPQLYNSKEDIKKELKKLNMSMIAAYLDLLDVLIRCPSDPERIQRIEQLRLLFINFHHLCNQLRPIQARDNLVAICEDQVIDIVRVAESLRQIVRLGKSDTYDLFKKYVKALKDKKDRYYKKKKSLIKEKKLEQVQQKMASEINYPSTDINIENMDEVGSLNNEINTMETCDKDMVFSTSNGVDNVNTSEHQGKESSLIFSRDEQLANIFNSLDIF
Length280
PositionMiddle
OrganismStrongyloides papillosus (Intestinal threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.08
Grand average of hydropathy-0.661
Instability index40.91
Isoelectric point6.05
Molecular weight32698.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05286
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.15|      17|      18|       7|      23|       1
---------------------------------------------------------------------------
    7-   23 (33.78/19.23)	TINV..SPFPFPPEYAQEY
   25-   43 (29.37/15.95)	TENIksGRFRYPPPIPKKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.51|      18|      18|     220|     237|       2
---------------------------------------------------------------------------
  220-  237 (32.88/22.11)	DEVGSLNN...EINTMETCDK
  238-  258 (27.63/17.64)	DMVFSTSNgvdNVNTSEHQGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.84|      14|      18|      50|      65|       3
---------------------------------------------------------------------------
   50-   63 (24.72/19.28)	YDRDND..KEPSLLDL
   69-   84 (19.13/ 6.17)	YNSKEDikKELKKLNM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05286 with Med7 domain of Kingdom Metazoa
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