Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MNRNEIESDLEDDYWNDALDETGNKIPSPELREDNEGDEGKKKSNVTSNNFRFVDPEDAKFEKLELDLGRFIEDVRQLGVTASDPGENANEIIRAKLRKIAAGLQNMNEVSSQFMNHQIPVKIFDFVDEMKNPNVYSKAVFEETDAKNSEVNGKIEQYKKYKSKILAKWAEEMPDAALQYMIMRKESESDKGPPFL |
Length | 196 |
Position | Middle |
Organism | Strongyloides papillosus (Intestinal threadworm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.923 |
Instability index | 42.02 |
Isoelectric point | 4.69 |
Molecular weight | 22517.84 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP05283 No repeats found |
MoRF Sequence | Start | Stop |
1) EIESDLEDDYWNDALD 2) IIRAKLRKI 3) LQYMIMRKE 4) NKIPSPELR | 5 92 178 24 | 20 100 186 32 |
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