<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05276

Description Uncharacterized protein
SequenceMANSLKNYKIPYWKSENYERRGIRKNSINRSFDIFYQDAMQDEDNISSIERITNGYVSNSLPHEYDSLILNQRNKISEDYIDNTTKKAHVFFDRLIEKRQLDSSKSHRKVLVPKVFQVSEWNYKVPKNQNISQFFENLAKEKDLFSLVKKFPSLGLRENFLEYLYEYNVPVLRAIWFIKILAILKATQTEDGKTPKKSQAQQTALEYVQCLISGYVIYTFKNLYTNGRCDEKKIEKWNYFALLIKHMFEEGVLDRQDFLTDVIDLLNIYVDYKLEDSTKFRILFLFVSQFSNYITQNIILARRMAFVICKRLRKYHLDYMNICGRPITCPEVMIELMKCQKHRPIILGMISMFYTIINECIQSITVKYITIDKKFTAITCYKDLTDTPLQYLTCRIDVMCEEAKLLPQNMVNLMRKKIEEFKRRSIDMKYNLHNVISHDNNCSEFSLMILKIFSILDGIYLVNEINMKKIYGSIFNLETNIDKEIEILIKLRIIIHWCITSQRSGSYRVIVVVKLLSLYLAGKKNPIKTMISIFNDYLCTEGPQLGYCNFGYEFRNIILLLNDLQQYGILKYEDLLNYWISMGKININECLWGKTLKYVYGENYERDLHPSWNRHIQMSSRYALMFYRRDSEKHTLINIETTTMEERIFLQMPIIPSIENRDIILFRDNIIYGISILRKERLNYLKEVARNIIKVWKKLYYFKIRINNGKSYFYEYHDIKRYNDCGDVLKIFRRQTYYDQTLITYWVGNDFKNCIKDFIENANNILPGSDGLDYILRMFCISMNIGGMIEYVVGLLELIAKLEDIMTTRGYNLISGMITKSYAFTIVGYLSEHTNYFLFHKNVVNVLNGLFRTIENTCMLENYPRTCYDTSIGMFICYCKNLLVREGIAGCNSILGCPKHFSKLYPSPFIEVKLDVPKMRAKKLFFGKYLRVSPQGMSITEFQHMSKKINKCGIPSRIEFILGVLQTVKELGRDINKISMLANYVGNVSVQLRMENEWLSVISEMCSLTSIPNTLYKGVHRTVNVGRTMTHYAISSFITILGAKYVFRPCELIKNLIKTTLVSVFKGSYLRSRYGYEKVILAALICTKLLTGYHDPFKLPRGYSGISEVKRPPVRRLADFKACNVLFNHEFNEIIFQFIQLLSFANRPIRKVKAKRASKRIRINHFFKACLLCLSEQPWFYQHMKFSILQTNLCTLNNENNLFKKYKITGTLLNFISRERGDRQNKLQILSCAEKLSKKSFIEKTLESLNIWNFRSVLLSLFGMVNDIARNPTKSNYARKIYNCNEAIADIAEGIKNIFIAPSKTYGKSIIFKTDTYFRLKDVSNLWLMEYFISEFPKITVHNYNIQFSKMSVIPLSKSVFIKLSSIVTESYSKNEYGKKTEQISHLFHIPPFSKLIQTLANAEPLCSHALLQGVYSYLTNIVKEFNTRRILCPQLSKEKDGIILRVLLVCGMIDQILTMPAVEPWAYLLWQLLYLEIISKEREEKYYFICYEALSTILFISTFKIQQRHNEKLHYRTRYKAYNHFCKKIRRECQDRPFPIEKMELSQLLPLPKRTFDYIIFDYYHKAIEKIHNSLSIEGPKEDGVKLNSRTGYYPIDKIKLTTFEIIPSFFHENLGRRPINYSFYQAQLVDYNPRAELNVFTKLLFHSHHRIFPKVPMYGGNNILKNSIFYQPPQIEYDKKEEKRKHSPLRELINMTSKPITENGTPKEQLKPNTTIKLTSPPKKDLQEKNINIGNSNNLKNQNFDHVKENEMKRNLNPSQQVFNGNGPNVPIPQQHSTQHVNQNQLVSQNSKIENNKYNYNPSQSSSVSGTQKVLKRSSSPISAMSVKKRKDDSENIPLPSKVNQQNTYLNMNPTNMLPRPPTNVYMQPPGTQKIMTSQPSGMPQHNFQQSNQMQMTINQQPPMSSNIENSNNQQRIPQQVKTMMNPQLRGNGMEQQRLMHQNPQQQRQNLALHNFMNPQQKGMLPGERQNMVGGYENPNMLKEMAQQRNNFGPNMPHQQQYNVPMNNQTLNQGPMMNQFQISQRKEMLYRNAQQHSQMQFQDPNMTRLYHQENPQQPLNGNQMFPR
Length2069
PositionKinase
OrganismStrongyloides papillosus (Intestinal threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.11
Grand average of hydropathy-0.406
Instability index47.61
Isoelectric point9.45
Molecular weight242881.16
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05276
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     346.82|      50|      54|    1845|    1894|       1
---------------------------------------------------------------------------
 1698- 1741 (36.76/13.41)	TSKPiteNGTPK..........E........QL..K.....PNTT.I.KL.TspP..KKDL....QEKNINI..............GN.......SNNL
 1742- 1781 (30.78/10.01)	KNQ..............NFDH............vkE.....NEMK.R.NL.N..P..SQ..qvfnGNGP.NV...PI.....pQQHST.......Q...
 1783- 1817 (24.28/ 6.30)	...............................VN..QnqlvsQNSK.I.EN.N..K..YNYN....PSQSSSV.............SGT.......QKVL
 1820- 1878 (72.43/33.74)	SSSP..iSAMSV....KKRKDDSeniplpskVN..Q.....QNTY.L.NM.N..P..TNML....PRPPTNV...YM......QPPGT.......QKIM
 1879- 1942 (59.27/26.24)	TSQP...SGMPQ....HNFQQSN...qmqmtIN..Q.....QPPMsS.NI.E..N..SNNQ....QRIPQQV..kTM......MNPQLrgngmeqQRLM
 1943- 1987 (36.47/13.25)	HQNP...QQQRQnlalHNF...............................mN..PqqKGML....PGERQNMvggY.......ENPNM.......LKEM
 1988- 2023 (37.13/13.62)	AQQR...........................................nNF.G..P...NMP....HQQQYNV...PMnnqtlnQGPMM.......NQFQ
 2024- 2062 (49.71/20.79)	ISQR...KEMLY....RNAQQHS......................qM.QF.Q..D..PNM.........TRL...YH......QENPQ.......QPLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     210.40|      55|      60|     426|     480|       2
---------------------------------------------------------------------------
  426-  476 (82.78/48.31)	............IDMKYNLHNVISHDNNCSEFSLMILKIFSILD.....GIYLVNEI....NMKKIYGSIFN
  477-  535 (71.35/40.55)	LETNidkeieilIKLRIIIHWCITSQRSGSYRVIVVVKLLS.........LYLAGKK....NPIKTMISIFN
  538-  601 (56.27/30.30)	LCTE..gpqlgyCNFGYEFRNIILLLNDLQQYG..ILKYEDLLNywismGKININEClwgkTLKYVYG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.88|      39|     114|     727|     776|       3
---------------------------------------------------------------------------
  727-  766 (64.13/36.03)	DVLKIFRRqTYYDQTLITYWVGNDFKNCIKDFIENANNIL
  850-  883 (56.83/29.29)	....LFR..TIENTCMLENYPRTCYDTSIGMFICYCKNLL
  896-  910 (14.92/15.43)	GCPKHFSK..LYPSPFI.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.58|      41|      44|    1309|    1351|       4
---------------------------------------------------------------------------
 1309- 1351 (65.97/58.67)	SIIFKTDTYFrLKdVSNLWLMEYFISEFPKIT...VHNYNI.QFSKM
 1352- 1396 (60.61/43.04)	SVIPLSKSVF.IK.LSSIVTESYSKNEYGKKTeqiSHLFHIpPFSKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.09|      14|      44|    1625|    1638|       5
---------------------------------------------------------------------------
 1625- 1638 (26.00/17.51)	FYQAQLVDYNPRAE
 1671- 1684 (27.09/18.63)	FYQPPQIEYDKKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.95|      33|      55|     952|     986|       6
---------------------------------------------------------------------------
  952-  986 (49.97/50.60)	CGIPSrIEFIL..GVLQTVkELGRDINK..ISMLANYVG
 1006- 1042 (49.98/38.79)	CSLTS.IPNTLykGVHRTV.NVGRTMTHyaISSFITILG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.32|      16|      32|    1190|    1205|       7
---------------------------------------------------------------------------
 1190- 1205 (28.02/17.26)	QTNLCTLNNENNLFKK
 1224- 1239 (24.23/13.78)	QNKLQILSCAEKLSKK
 1243- 1255 (17.07/ 7.19)	EKTLESLNIWN..FR.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.07|      14|      46|    1110|    1123|       9
---------------------------------------------------------------------------
 1110- 1123 (25.72/20.73)	KRPPVRRLADFKAC
 1145- 1158 (20.25/14.20)	ANRPIRKVKAKRAS
 1159- 1170 (22.10/16.41)	KRIRINHF..FKAC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.31|      21|     187|    1257|    1278|      18
---------------------------------------------------------------------------
 1257- 1278 (32.69/26.99)	VLLsLFGMVNDIARNPTKSNYA
 1447- 1467 (39.62/27.81)	VLL.VCGMIDQILTMPAVEPWA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05276 with Med12 domain of Kingdom Metazoa
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