<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05274

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSENSNSDDNGYDKKDDSFEITIPEFPNDSSDDPSFSDNENLQVKKKLEKGEKLPNLPHVAEQHAPGTMPLAVLLQFVCQKINQELFSLTEIVCNTSDIGRKVALVQFSYTAKNLLSKLLAIVKWFRYFKRYRLCIPIQNFLDQQLQHYRETADTLCGIARGELTYARMPPYNIDSAIDVVCGVYARLPQSIKKRFIPEPELSTQEIANILARINLAIKTRLSFMAQSFPTQIKNIIVHNGTVTFVVPGEFEITLTLPGETLDVKWRLLRVRILVQDYEFGDGKELVHHLQLKKLHKFCQKLLDTSKKPIISVFNFLHDFCVTLQFDLIFGEILQLTQGTYRNKVFINTCNVQKRYISLKYWVKKRTKKTPSSYNQIVFYISNKSKDGGVVVEFRPSNSFPLDVYKEFEGKPSVHNILRSAIEYNIYRKLTILKEQLEKCRPKSSVKLTGDLLPKVTYYLLSKDFDGENDELSFGVNFSTGEYMYVGDNLKESLLLKAMVVGLNNNIEHKKLERCLDGIRTEFIMKKYVKSVNMLNVKLVPEKILPSISRKYAFFEHSVKLYFQIIKEPQHYVVLTFTDPKRKGLWVNFFLISLNEGKSTVVKLNPSEFYTPSKINTPDERYYLGEIGNSIKYSKKGCSLQYTPHEVGAIINGIENKVNMIAVCDEFLKKNVTLGFVKNDCISNSPYLEIPNISKLIGSDNSKFFDNMKRIILRNDARFKHIWPLEYLLINTPIVEDFYKRDINGQNLVRLTGKKRCFHDIRSSGIVLPIVSFYEVITSALVDKMKTFSMLYKHVFEFAHSYYRYYNNYCRIKLYSYHKLIIAYGEDRDQLVFLTYKASKDSFLLSFGQDSKQNFVNGDTNDSSDQEPSTLWNPHNLVANFLSEKSGRKNFLPELVDYLINTTRPLTSLCKGIRHKIICSSALTQILIGESMYSEEFDIQLVPHSEYIFKIICGHMIIEVFMYAKNYVYLKDSSYEKARLYGFKELLKGFGGNIIDMSAIVNDETSIEKGARSLPASNREEMEEVMRNPLSLPSSMSVDGKGNDNYTPMDDDTRSKEKYNEEYFSSSRDLIKMSHDSFDKLLYQDPKIKPISDLRNYLYSLRSFERITTILVHNYGKPILGGGGLMIHNVNVAHYMVRATFSAAKRSDGHVPCNINFIVFIEPDTFKIKLKLEYTGAFRPTDDEIKIAEEYFEYVLRYTESPQMVYSFMNLIRMIFPRFFSCITNLMSLQLNPDPLNFYTMNFEFVNLLHRKEDSMPKYVSQILINEHSGRILIPITIRPQNIYPNYKNNEPNSKIKLDFVWEAANNEVYIHNVNDDFFKMINQRIIQFNSTIKESMECTLEACIRYILKNEIKSI
Length1356
PositionTail
OrganismStrongyloides papillosus (Intestinal threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.12
Grand average of hydropathy-0.295
Instability index40.13
Isoelectric point8.73
Molecular weight157202.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05274
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     423.14|     145|     168|     105|     272|       1
---------------------------------------------------------------------------
   23-   91 (40.40/19.57)	..........................................................................................................IPEfpndssddPSFSDN...E........NLQVKKKLE.KGEKLPNLP.HVA....EQHApGTMPLAVLLQFvcqKINQELFSLT..........E
  105-  272 (222.48/231.73)	LVQ.FSYTAKNLLSKLLAIVKWFRYFKRY.....RLCIPIQNFLdqqlqHyretadTLC.....GIARGELTYARMPPYNIDSAIDvVCGV...YARLPQSIKKRFIPE........PELSTQ...EIANILARINLAIKTRLSfMAQSFPTQI.KNI....IVHN.GTVTFVVPGEF...EITLTLPGETldvkwrllrvR
  274-  416 (160.26/118.43)	LVQdYEFGDGKELVHHLQLKKLHKFCQKLldtskKPIISVFNFL.....H......DFCvtlqfDLIFGEILQLTQGTYRNKVFIN.TCNVqkrYISLKYWVKKRTKKT........PSSYNQivfYISNKSKDGGVVVEFRPS...NSFPLDVyKEFegkpSVHN....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     548.89|     152|     169|     659|     827|       2
---------------------------------------------------------------------------
  548-  656 (108.66/63.77)	...............................................................ISRKYAFFEHSVK..LYFQIIKE..P...............QHYVV.LT.....FTDPKRKGlwVNFFLISlnegkstvvklnpseFYT......PSKINTPDERY.Y....LGEIGNS..IKYSKKGCSLQ.YTPHEVgaIINGIEN
  659-  827 (249.85/200.09)	NMIAVCDEFLKKNVTLGF........VKNDCISNSpyleipniskliGSDNSKFFD..NMKRIILRNDARFKHIWP..LEYLLINT..PI...VEDFYKRDINGQNLVR.LTGKkRCFHDIRSSG..IVLPIVS...............FYEVItsalVDKMKTFSMLYKH....VFEFAHSY.YRYYNNYCRIKLYSYHKL..IIAYGED
  830-  993 (190.38/124.16)	QLVFLTYKASKDSFLLSFgqdskqnfVNGDTNDSS............DQEPSTLWNphNLVANFLSEKSGRKNFLPelVDY.LINTtrPLtslCKGIRHKIICSSALTQiLIGE.SMY....SEE..FDIQLVP...............HSEYI..........FKIICGHmiieVFMYAKNYvYLKDSSYEKARLYGFKEL..LKGFGGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.28|      41|     125|    1162|    1213|       3
---------------------------------------------------------------------------
 1162- 1205 (62.59/63.17)	EPDTFKIKLKLeYTGAFRPtdDEIKIAEEYFEYV..LRYTES..PQMV
 1216- 1260 (66.69/37.53)	FPRFFSCITNL.MSLQLNP..DPLNFYTMNFEFVnlLHRKEDsmPKYV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.47|      36|      39|    1002|    1039|       4
---------------------------------------------------------------------------
 1002- 1039 (52.05/44.35)	NDE.TSIEKGARSLPASNrEEMEEVMRNPLSLpSSMSVD
 1043- 1079 (60.43/40.40)	NDNyTPMDDDTRSKEKYN.EEYFSSSRDLIKM.SHDSFD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05274 with Med14 domain of Kingdom Metazoa
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