<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05270

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNYDGGNDSVPFGVLLKYSCHKISQELIVISELLPKYKDYNRKITITEFSYMARCLVSKILAIVKWLRSYNEHKRCKEIQSFLETQEHYFRDTADALCAIARNELVIARVPMYEVDAAVRLSYGQDIVMPLAIKKRFVPEKRLTKSERSRILSAINKNIYNRLSVISSILPSKIDGITIKNGVVTLTVPGEFEVSLTLFNDDLSTKWTLLDIKILVEQYDVGYGTKLVHPMQLFSMHQYLQQKMLISKNPIIDLYNYLHDFCTSLQLDVLFCETSQLIGAQYKNKLIIEKYDQDGGVLVISFWPVLKRKQYFPSQYKIKVFKDTSKLNSGLRVMQYPLRRNMPTLDLDTGRLSMCRLINETVLIYAKEKLFNLKKKLTCLKPYTYVEVTGGNYPKIDYWLFEESEHPEEECLTIHVNMFTGKFVPTLPSFKCKDMLEKLADMLNNDAPNRDLEVFLRNLKMQFLVNRIKKVYAEIKLPLIKENIDLKGVNITCDDDKKIFGRITNTDNFIVTQLVASKDTNEILFNFFVYEKRKEILTKYFGFHGDELNIENKRLNKAGSLWEKSTEGLCNNVQMFSQTSSNYIGKRDVWIGNYKNLLSSCYVILHEWQLNAISMAYSKGSYGEKDIKRECNNVPYLTLNSIKSLPGGGTGNVLAYEKCFMRMDDRWCYPKPGAYTVELFIRNVALKVDYYMNCPARENLSHKYGIKGTTIGIPYNIYWLYPLNFTKKIAEILALERCRILNFYKLLEDIAPHYYKFFNQYCSVKHLSNYKVVFAYGEDRKYLLYLIFSGSKAESYKFYFGQDSSINYVNGTVLDITSPWKKGFNAHNNVHEHLLKWKLDKKHLHHLLLYVVKTCTPINILYNVNIPQMYSGVFVNEMVNRNYQMKKLAPARLVAIDEYHIRLIFADAVVEFWVGSEDNVLICDVSKDSSKISGLHSVIYTYSSKMKLYNKPFFEMTNDECNGFFEVRNEHFQVNSNTLKKLCLDVEPCNQYGVLIEYLHSQHIINHIKLLTKVYSLEKAECPPILNFFNISTTQGSVSFNVQYLLLDTETRDHNNINTIIYIDTNYFALRIVLDIDAGFPVQESLIQISQKYFEKIICYNYNNLSFFGFFKLLLTPSQDALNAIENIFRYELESTISSDRTSVSIQWIRESLRSGHNANILSSFVESNFDEGYIVIPIKITDVVKEKRMLLNTNVFHLKYHYHTGLVESTDDEEVYPNLNSYLLTYSKEARTYKKDPVLLSIQNIIKNYIPVLKS
Length1256
PositionTail
OrganismStrongyloides papillosus (Intestinal threadworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Strongyloides.
Aromaticity0.12
Grand average of hydropathy-0.207
Instability index38.96
Isoelectric point8.68
Molecular weight146171.32
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05270
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1313.58|     285|     287|     544|     830|       1
---------------------------------------------------------------------------
   15-  240 (185.31/112.16)	........................................................................LLKySCHKISQE..LIVISELLPK..Y....KDYNRK.......ITITEFS.YMARCLVSKILAI..VK.WLRsyNEHKRCKEiQSFLETQ..EHY......FRDTA...DAL......CAiARNELviarV.PMYEV.DAAVRLSYGQDIVMPLAIKKRfVPEkrLT...KSER.....S.RILsainkNIYNRLSVIS...............SilpskidgitIK...NGV.VTLTVPGEFEVSLTL.F...N.................DDLSTKW.......TLLD..IkilVEQYDVGygtklvhpmqlFSMHQYL....
  252-  547 (341.84/215.11)	I..DLYNYLHDFCTSLQLDVL..FCETS.........QLIGAQYKNklIIEKYDqdggvlvisFWpVLKRKQYFP.SQYKIKVFKDTSKLNSGLRVMQY.....PLRR....NMPTLDLDTGRlSMCRLINETVLIYakEKLF.N..LKKKLTCL.KPYTY.V..EVT......GGNYP.KIDYWLfeesEHP.EEECL....TiHVNMFTG.KF.VP.TLPSFKCKDMLEK.LAD..MLnndAPNRdlevfL.RNL.....KMQFLVNRIKKVYAEI..KL....PL..........IKENIDLKgVNITCDDDKK.....IF....G.....RITNTDNFIVTQLVASKDTN....EILFNffV...YEKRKEI...........LTKYFGFHGDE
  548-  834 (480.17/311.28)	L..NIENKRLNKAGSLWEKSTegLCNNV.........QMFSQTSSN..YIGKRD.........VW.IGNYKNLLS.SCYVILHEWQLNAISMAYSKGSY..GEKDIKRECN.NVPYLTLNSIK.SLPGGGTGNVLAY..EKCFMR..MDDRWCYP.KPGAYTV..ELF......IRNVALKVDYYM....NCP.ARENL....S.HKYGIKGTTIGIPYNIYWLYPLNFTKK.IAE..IL...ALER.....C.RIL.....NFYKLLEDIAPHYYKFFNQY....CS..........VKHLSNYK.VVFAYGEDRKYLLYLIF...SG.....SKAESYKFYFGQDSSINYVN....GTVLD..I...TSPWKKG...........FNAHNNVHEHL
  835- 1128 (306.26/191.83)	LkwKLDKKHLHHL.LLYVVKT...CTPInilynvnipQMYSGVFVN..EMVNRN.........Y....QMKKLAP.ARLVAIDEYHIRLI.FADAVVEFwvGSEDNVLICDvSKDSSKISGLH.SVIYTYSSKMKLY..NKPFFE..MTNDEC....NGFFEVrnEHFqvnsntLKKLCLDVE.......PC.............NQYGVL.....IEY.LHSQHIINHIKL.LTK..VY...SLEK...aeCpPIL.....NFFNI..STTQGSVSFNVQYllldTE..........TRDHNNIN.TII.YIDTNYFALRIVLdidAGfpvqeSLIQISQKYFEKIICYNYNNlsffGFFKL..L...LTPSQDA...........LNAIENI....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05270 with Med14 domain of Kingdom Metazoa
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