<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05270
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MNYDGGNDSVPFGVLLKYSCHKISQELIVISELLPKYKDYNRKITITEFSYMARCLVSKILAIVKWLRSYNEHKRCKEIQSFLETQEHYFRDTADALCAIARNELVIARVPMYEVDAAVRLSYGQDIVMPLAIKKRFVPEKRLTKSERSRILSAINKNIYNRLSVISSILPSKIDGITIKNGVVTLTVPGEFEVSLTLFNDDLSTKWTLLDIKILVEQYDVGYGTKLVHPMQLFSMHQYLQQKMLISKNPIIDLYNYLHDFCTSLQLDVLFCETSQLIGAQYKNKLIIEKYDQDGGVLVISFWPVLKRKQYFPSQYKIKVFKDTSKLNSGLRVMQYPLRRNMPTLDLDTGRLSMCRLINETVLIYAKEKLFNLKKKLTCLKPYTYVEVTGGNYPKIDYWLFEESEHPEEECLTIHVNMFTGKFVPTLPSFKCKDMLEKLADMLNNDAPNRDLEVFLRNLKMQFLVNRIKKVYAEIKLPLIKENIDLKGVNITCDDDKKIFGRITNTDNFIVTQLVASKDTNEILFNFFVYEKRKEILTKYFGFHGDELNIENKRLNKAGSLWEKSTEGLCNNVQMFSQTSSNYIGKRDVWIGNYKNLLSSCYVILHEWQLNAISMAYSKGSYGEKDIKRECNNVPYLTLNSIKSLPGGGTGNVLAYEKCFMRMDDRWCYPKPGAYTVELFIRNVALKVDYYMNCPARENLSHKYGIKGTTIGIPYNIYWLYPLNFTKKIAEILALERCRILNFYKLLEDIAPHYYKFFNQYCSVKHLSNYKVVFAYGEDRKYLLYLIFSGSKAESYKFYFGQDSSINYVNGTVLDITSPWKKGFNAHNNVHEHLLKWKLDKKHLHHLLLYVVKTCTPINILYNVNIPQMYSGVFVNEMVNRNYQMKKLAPARLVAIDEYHIRLIFADAVVEFWVGSEDNVLICDVSKDSSKISGLHSVIYTYSSKMKLYNKPFFEMTNDECNGFFEVRNEHFQVNSNTLKKLCLDVEPCNQYGVLIEYLHSQHIINHIKLLTKVYSLEKAECPPILNFFNISTTQGSVSFNVQYLLLDTETRDHNNINTIIYIDTNYFALRIVLDIDAGFPVQESLIQISQKYFEKIICYNYNNLSFFGFFKLLLTPSQDALNAIENIFRYELESTISSDRTSVSIQWIRESLRSGHNANILSSFVESNFDEGYIVIPIKITDVVKEKRMLLNTNVFHLKYHYHTGLVESTDDEEVYPNLNSYLLTYSKEARTYKKDPVLLSIQNIIKNYIPVLKS |
Length | 1256 |
Position | Tail |
Organism | Strongyloides papillosus (Intestinal threadworm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida>
Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae>
Strongyloides.
|
Aromaticity | 0.12 |
Grand average of hydropathy | -0.207 |
Instability index | 38.96 |
Isoelectric point | 8.68 |
Molecular weight | 146171.32 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP05270
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 1313.58| 285| 287| 544| 830| 1
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15- 240 (185.31/112.16) ........................................................................LLKySCHKISQE..LIVISELLPK..Y....KDYNRK.......ITITEFS.YMARCLVSKILAI..VK.WLRsyNEHKRCKEiQSFLETQ..EHY......FRDTA...DAL......CAiARNELviarV.PMYEV.DAAVRLSYGQDIVMPLAIKKRfVPEkrLT...KSER.....S.RILsainkNIYNRLSVIS...............SilpskidgitIK...NGV.VTLTVPGEFEVSLTL.F...N.................DDLSTKW.......TLLD..IkilVEQYDVGygtklvhpmqlFSMHQYL....
252- 547 (341.84/215.11) I..DLYNYLHDFCTSLQLDVL..FCETS.........QLIGAQYKNklIIEKYDqdggvlvisFWpVLKRKQYFP.SQYKIKVFKDTSKLNSGLRVMQY.....PLRR....NMPTLDLDTGRlSMCRLINETVLIYakEKLF.N..LKKKLTCL.KPYTY.V..EVT......GGNYP.KIDYWLfeesEHP.EEECL....TiHVNMFTG.KF.VP.TLPSFKCKDMLEK.LAD..MLnndAPNRdlevfL.RNL.....KMQFLVNRIKKVYAEI..KL....PL..........IKENIDLKgVNITCDDDKK.....IF....G.....RITNTDNFIVTQLVASKDTN....EILFNffV...YEKRKEI...........LTKYFGFHGDE
548- 834 (480.17/311.28) L..NIENKRLNKAGSLWEKSTegLCNNV.........QMFSQTSSN..YIGKRD.........VW.IGNYKNLLS.SCYVILHEWQLNAISMAYSKGSY..GEKDIKRECN.NVPYLTLNSIK.SLPGGGTGNVLAY..EKCFMR..MDDRWCYP.KPGAYTV..ELF......IRNVALKVDYYM....NCP.ARENL....S.HKYGIKGTTIGIPYNIYWLYPLNFTKK.IAE..IL...ALER.....C.RIL.....NFYKLLEDIAPHYYKFFNQY....CS..........VKHLSNYK.VVFAYGEDRKYLLYLIF...SG.....SKAESYKFYFGQDSSINYVN....GTVLD..I...TSPWKKG...........FNAHNNVHEHL
835- 1128 (306.26/191.83) LkwKLDKKHLHHL.LLYVVKT...CTPInilynvnipQMYSGVFVN..EMVNRN.........Y....QMKKLAP.ARLVAIDEYHIRLI.FADAVVEFwvGSEDNVLICDvSKDSSKISGLH.SVIYTYSSKMKLY..NKPFFE..MTNDEC....NGFFEVrnEHFqvnsntLKKLCLDVE.......PC.............NQYGVL.....IEY.LHSQHIINHIKL.LTK..VY...SLEK...aeCpPIL.....NFFNI..STTQGSVSFNVQYllldTE..........TRDHNNIN.TII.YIDTNYFALRIVLdidAGfpvqeSLIQISQKYFEKIICYNYNNlsffGFFKL..L...LTPSQDA...........LNAIENI....
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