<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05263

Description Uncharacterized protein
SequenceMSRRYEGDEDEEEFLRPILPTVPEKCGTPTITLGLLMDFAVQQTYHELTVLAELLPKKLDADRKISIIQFAHSTRTLFIKLLAVVKWIKSSKKFDSCSSICYFLDQQAQYFIDTADYLVTLAREELVHARLPAFQVPAAIDVLTLGDFPRLPVCITSQFVTDRSITKREETSVLYRLNQVLKTKLSQASPSLSHRIREISFKNGMVNLVVPGEFEVSLTLLGQKPTTKWTLLNIRFLVEDYEIGFGTQLIHPLQVNSVHNLLQLRMDQSEEPLKEVYNILHSVAQSLQLDILFCQATQVISGHMRKYAIIENYNREEGVLVIAYWLRWTQQKRYLSQYRIKIFIDSSDPHTGLRIRHYPPNKRLPSIDDRSGRLSMNKILSQTMSIRCHEKLLRIRKGLENIKPLTRVLLTGNATFTLTYPLLDKRSHISEKLVVSVNNFSGRIEAVVAALDDCKEVKELALLFNEDATLEKISTVIQRLRILVMMERFRKAVASLPVRIVDESFVYAQFSSLKIISPDRLCFQFIKEDIYFLVVSFKARSKGNVDLEIYLFSAVDGRTNRLQLHPSQMLETWTSANFRLDSSDPAAKRQRWLGSTKQLTSAISAIDDRLAFMRLCDELDKRKVKYLPLETERVVGGLILRITDFSEAIASGSKDFFELLVNCCLRLDTRARVIWPFEYTLSENPLTPDYYESNDRASSKAERTKTTVLEIYANAGFSQHSTSESVYCTMLERLIVYSHVYDVAKHFAKAYYSHFYKFCNISAFTYYKLVIAYGEFRNNLMLLTWKVQKIPKPAQYFHLTFGMYSFRDVANAKNFATPPKELLWNPHTILQSRLQDMFNRKRSLIDLMQYLIDTVEPLSCLCNFAHTRLQSLRTYAQIMSYETALPISLQTDLVVVNETTLRLIYGPVTLEFLLLGDSKVGIRDASRRMPAAAHLRGFCNKFMNQELIGAIHEGHSPGPGWLRSPSTQNTLSHHMGRSPAMRLTSSPISHVPLSVSTSDLEMSPMRPSENVSLSRVPLLIDHAALRRMTTVDSSGFCPLHEYLFASSYLARLGPALENYQVEHRNNAHSAIQFGYLRHTVDSVQFSVPCAVPSKRDFLTLNIYLDEKTMSLKSELKYEGDEVPSRNDVEIAERYFERCVAPLNNELAVIAFANACRLTTMGTFASMTQIMEAQMMWREDSSWKPSLQLVTSGTDSTTQRMRVTPGVIIDPSNVNVLILLCLRPSHPEYVDRAADPSKHLIQLIYNTQTNTVGRRSPAEDDSNNIASILSGVSEQYARTNERSLWPAVRTLAYKYVQS
Length1297
PositionTail
OrganismSyphacia muris
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Oxyuridomorpha> Oxyuroidea> Oxyuridae> Syphacia.
Aromaticity0.09
Grand average of hydropathy-0.170
Instability index46.42
Isoelectric point8.77
Molecular weight148236.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05263
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.94|      26|     206|     324|     373|       1
---------------------------------------------------------------------------
  344-  370 (46.93/72.99)	IDSSDPhTGLRIRHYPPNKRLPS....IDDR
  580-  609 (43.00/12.39)	LDSSDP.AAKRQRWLGSTKQLTSaisaIDDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     709.57|     188|     737|     109|     316|       2
---------------------------------------------------------------------------
  109-  300 (298.00/220.25)	QYFIDTADYLVTLAreELVHARLPAFQVPAAIDvlTLGDFPRLPVCITSQFVTDRSITKR...EETSVLYRLN.QVLKTKLSQAS...PSLSHRIREISFKNGMVNLVVPGEFEVSLTLL...........GQKPTTKWTLLNIRFLVEDYEIG.......FGTQLIH.PLQVNSVHNLLQLR......MDQSEE.PLKEVYNIL.HSVAQSL.QLDIL.FCQATQVI
  849- 1043 (248.78/170.88)	QYLIDTVEPLSCLC..NFAHTRLQSLRTYAQI....MSYETALPISLQTDLVVVNETTLRliyGPVTLEFLLL.GDSKVGIRDASrrmPAAAH.LR..GFCNKFMNQELIGAIHE................GHSPGPGWLRSPSTQNTLSHHMGrspamrlTSSPISHvPLSV.STSDLEMSP......MRPSENvSLSRVPLLIdHAALRRMtTVDSSgFCPLHEYL
 1085- 1237 (162.79/132.04)	.........................FSVPCAVP..SKRDFLTLNIYLDEKTMSLKSELKY...EGDEVPSRNDvEIAERYFERCV...APLNNELAVIAFANA.CRLTTMGTFA.SMTQImeaqmmwredsSWKPSLQLVTSGTDSTTQRMRVT.......PGV.IID.PSNVN.VLILLCLRpshpeyVDRAAD.PSK.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.86|      13|      27|     766|     778|       9
---------------------------------------------------------------------------
  766-  778 (23.83/14.15)	YYKLVIAYGEFRN
  796-  808 (26.03/16.11)	YFHLTFGMYSFRD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05263 with Med14 domain of Kingdom Metazoa
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