<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05251

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTEDDWPSQRFRDNVINRLEPELARNRQNAPNLPVPGDARQVEEYVFNKCHSKDEYMRTIAKVINAINCNSKSAAAPSPSTMVHSPSYQASQAPPSSYRVSGVPPDPQPTQQEASQAREQFQAPPLGQPPPMIPSQQTSPLGINISGMNQGVQRSPIGQHNAVPHQQPQQQPFMMSTSVPSMPPAQSSPTHQMYNRMKPVEQKVSSDVMQRETMARSWKQPEMAQNAYTAQPFGSASASFLEPMHPSTSHSQPQRMMPGHSMQQQSQPGSILEHLINSSQYSSQPSQSQRVYEARLRRLMKYAEPLRAKSRQCRMEGNDTAAAKFEAMSEMVEGKRQAIVVTSRVVSMEYLEQLEEWIYKKHDLLQGPGLPSVANQQSQPPLVAAVNAVLLNGDSQGTTGERLPPSQGIMAPGTQWGPSPKQRSSHSTSNHVPQNLISPITINSPMSNLPVPNSVPLSPQMHSPQMIPVSQGIQQMHHPVDHTHYQRPSPYPHPMTTLRNSPQYQQPASAPQNAMTGMNPQVDAAIDVPTVGSQPHDEFYPSVEDFLPTPYESVQPASAMLIGGQLPEKARHELMCFNDRISFDPNIELTSDGHGMIVKCSLLSHSVPPLRLIIPKSYPNGCLSAERAALDLDSFYFDDLQSLIHDRLADRSLTTISDYLETWESVVRNYYLTQQNQTPVQTSFDDILQNNFDDILSS
Length698
PositionTail
OrganismSyphacia muris
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Oxyuridomorpha> Oxyuroidea> Oxyuridae> Syphacia.
Aromaticity0.06
Grand average of hydropathy-0.672
Instability index73.25
Isoelectric point6.09
Molecular weight77589.23
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05251
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     325.63|      46|      46|      95|     140|       1
---------------------------------------------------------------------------
   95-  140 (85.65/29.58)	PSSYRVSGV..PPDPQ.......PTQQEASQAR.........E.....QFQAP.P..LGQ..P.....PPMI.....PS.QQTSP
  142-  189 (54.62/16.32)	..GINISGM..NQGVQ.....rsPIGQHNAVPH.........Q.....QPQQQ.PfmMST..S.....VPSM.....PP.AQSSP
  199-  253 (40.70/10.37)	PVEQKVSS.....D..........VMQRETMARswkqpemaqN.....AYTAQ.P..FGS..AsasflEPMH.....PStSHSQP
  381-  426 (58.03/17.78)	PLVAAVNAVllNGDSQ.......GTTGERLPPS.........Q.....GIMAP.G..TQW..G.....PS.......PK.QRSSH
  452-  509 (40.34/10.22)	PNS.....V..PLSPQmhspqmiPVSQGIQQMH.........HpvdhtHYQRPsP....Y..P.....HPMTtlrnsPQyQQPAS
  511-  558 (46.29/12.76)	PQN.AMTGM..NPQVD..aaidvPT..VGSQPH.........D.....EFY.P.S..VEDflP.....TPYE.....SV.QPAS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.89|      21|     284|       8|      28|       3
---------------------------------------------------------------------------
    8-   28 (37.84/25.34)	SQRFRDNVINRL....EPELARNRQ
  288-  312 (31.05/19.56)	SQRVYEARLRRLmkyaEPLRAKSRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05251 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GDSQGTTGERLPPSQGIMAPGTQWGPSPKQRSSHSTSNHVPQNLISPITINSPMSNLPVPNSVPLSPQMHSPQMIPVSQGIQQMHHPVDHTHYQRPSPYPHPMTTLRNSPQYQQPASAPQNAMTGMNPQVDAAIDVPTV
2) INCNSKSAAAPSPSTMVHSPSYQASQAPPSSYRVSGVPPDPQPTQQEASQAREQFQAPPLGQPPPMIPSQQTSPLGINISGMNQGVQRSPIGQHNAVPHQQPQQQPFMMSTSVPSMPPAQSSPTHQMYNRMKPVEQKVSSDVMQRETMARSWKQPEMAQNAYTAQPFGSASASFLEPMHPSTSHSQPQRMMPGHSMQQQSQPGSILEHLINSSQ
3) MTEDDWPSQRFRDNVINRLEPELARNRQNAPNLPVPGDARQVEEYVFN
393
67
1
531
280
48










Molecular Recognition Features






MoRF SequenceStartStop




NANANA