<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05245

Description Uncharacterized protein
SequenceMSSGGTGKSLNVVTWHNQTSQRRPLKRGRLGPPDVYPQEPKQDEDNLGDDRLRKGYQVAITSYEHESIVWNAKVPRLNKLDETMSRGAQIIMQVMNRKAELNANLDKERKRGSKEGAFQGFSHTTTQAVKSKERKEWFLDLARGKSLASLVKRPPFFKKKEGALEYLCDYKVPVLRALWYLKLTAVGQAVASNLAKQKKSFIDQLACEQGALFTKFIRCMLTQISETHNLEQNLVYTERWPYFVCLCKHAYEDGMLERQEFLMDLCDIFGERFLTTSDNKPHFFTLFRMFLMFFSQYIDQITQNLILSRRCAYLIARRLAICKEEAESLSGGDKLINCKELFHGMMQCQNQKPIISILTGMLHAILIDCPAALVWNSFQVSEGKFPPMVQQLCGSPLDQLPCDIEDLPTLPGYGSDKMKELIQERVNEVRRRSIAVENHWSLNRMKKTNFATVVYACLEVLGALDAARIDQPRYIEKIYNIVFGGQNEEKFEYEDAIRVKVLLHWAVTVEREGTHRALVVAYILNYRKHRKEKQFGDEELQNILLEYLNTEAPQPTDLHFEEEFKNLMLLFYELQKLQLFSHDSYVSGLITTGEMSYQTPVLALIKSRESAAAASQNNDGQATKNNVNGGEEKLNNDGLGTSIAEMQKDLPDEHPFMGNELSQHERLLIHFPIPQSKQFRSDCNQRALLLHGVGEQREVALNDLRKVAKEIIKIWSKRIVIEFSQKPVEIRFKKRATPEQINSAVQKFKVQSYYDQVVLCGWFTEVFISMVSDFVDGHNSVLPSAEGLDVLLSMLDHCKFISGIMDFAKYLLPLLVELERKLTEQRVDCIPSNISAQLGFVLVAYISHHFNYFVLSKHAVDVVNGLYRIVEKQLSAKYLTGWGRTIAIFVTNTKKFLLETDLPRKKLEVKHEEPVRIAPVKQQLNTGAKYNADVFKKLLDSPRRIFSFNDYREWCTILEKFCDARYKFVVSAVKCAHHCGDNYDRLVELANICGHISAIASLSSEWCAAMQALCCSSVAGNHGFEELLFDINVEDSKCHTTLATFYMLLAGRSCFSMNVLFHELLHTVFRTLINSDSSKTDVDAEPGVCLALLVLANMVCQSEKPIILSPVYAGENYTDRQLFGMADKYILSASHLFDMNNTIFDLLFSIASISDCSKNKLRDYHDENKGDQGFCREYIAQLSKAVLLAMCEQDWITQRVYRICEESSLDLFNSPNLRKNGLGQQLLRMALRRKCERKVVNDLTICNGNSKKSLIDKLFSVLNIWNMRATYFDLKLMIKEISPEGTGKVVQQGAIAADALIGEIGKCCRDLFVNSRGKAESLPENATGKGFRLKYINNFWLISPLIHSCPKPVNLPTSFSGLTVQTKFLKEAALMLDTTTNCSHERVKQSVWLLSQEPFINLVLTCIKGEDLQRDGLVTSILKQLQEVASKIKDNPFLPYINKFSLEREGILLRCSLIGGMFDSVCHQMCCDAWALLFFQLMIYGVISLEKDGCSFESCYDMLSTLLIWSKTDPVNVTAINSQDPDTKYRFGSYASIIKKLKKELNERTLIPELRSLLQFLPISKSTFDVVSAETYGTVVTSPQKLSKGQFGTTPSKVFRIGLQLGEKSKLSAYDMIQNFNSESAVKRSWNWAMFQAVKLDKSPVPIQRHIQRLIQHTHYIEFSRPAICGGPIGPMKECALEFLSPPVMDTETSMRLPSAVGSASSISGSVPTGTNAPTTGNSASSELPVGPNRPIGYQNGTPINVNQNSNAESMMFAGSLQAVPDLNRNPASASPRGGRGGRRRGTGPASRATGTIRKKRQALEKAQGLASQIAQGVSSATAPTNTTFWGGQPAPQNPPMGYMSAQQAAISQQENSKTTIQRFVMKRQAANASSSSAQGFGAMTSASGNQYNPMMMKMENGVAPMDHQQSYSGPTPQLGMVQDQQRTQFGSQQDVYVQQAQPNPTN
Length1947
PositionKinase
OrganismSyphacia muris
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Oxyuridomorpha> Oxyuroidea> Oxyuridae> Syphacia.
Aromaticity0.09
Grand average of hydropathy-0.274
Instability index40.13
Isoelectric point8.60
Molecular weight219186.43
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05245
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.67|      11|      36|     158|     169|       1
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  130-  140 (20.69/12.79)	KSKERK.EWFLD
  158-  169 (15.98/14.00)	KKKEGAlEYLCD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     365.65|     112|     126|    1709|    1826|       2
---------------------------------------------------------------------------
 1709- 1826 (180.49/138.00)	GSVPTGTNAPTTGNSA.SSELPVGPNRPIGYQNGTPINVNQNSNAESMMFAGSLQAVPDLNRNPASASPRGG...RGGRRRGTGPASRaTGTIR.KKRQALEKAQGLASQIAQgvssaTAPTN
 1831- 1947 (185.16/126.50)	GGQPAPQNPPMGYMSAqQAAISQQENSKTTIQRFVMKRQAANASSSSAQGFGAMTSASGNQYNPMMMKMENGvapMDHQQSYSGPTPQ.LGMVQdQQRTQFGSQQDVYVQQAQ.....PNPTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.90|      14|      30|     767|     783|       3
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  767-  783 (20.88/20.39)	FISMVSDFVdghNSVLP
  800-  813 (27.03/15.52)	FISGIMDFA...KYLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     211.55|      49|     126|    1127|    1175|       4
---------------------------------------------------------------------------
 1127- 1175 (85.67/62.37)	DKYI..LSASHLFDM..NNTIFDLLFSIASISDCSKNKLRDY....HDENKGDQGFC
 1176- 1223 (56.76/38.41)	REYIaqLSKAVLLAMceQDWITQRVYRI.....CEESSLDLF....NSPNLRKNGLG
 1256- 1307 (69.12/48.65)	DK.L..FSVLNIWNM..RATYFDLKLMIKEISPEGTGKVVQQgaiaADALIGEIGKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.70|      26|     121|    1414|    1450|       5
---------------------------------------------------------------------------
  637-  662 (48.21/19.57)	DGLGTSIAEMQKDLPD...EHPFMG..NELS
 1415- 1445 (35.48/30.18)	DGLVTSILKQLQEVASkikDNPFLPyiNKFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.66|      28|     125|     190|     219|       7
---------------------------------------------------------------------------
  190-  219 (44.82/41.48)	VASNLAKQKK.....SFIDQL.ACEQgaLFTKFIRC
  315-  348 (42.85/31.50)	IARRLAICKEeaeslSGGDKLiNCKE..LFHGMMQC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.02|      13|      23|     534|     547|       9
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  534-  547 (19.47/15.38)	QFgDEELQNI.LLEY
  559-  572 (20.56/10.59)	HF.EEEFKNLmLLFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.74|      18|      20|     228|     247|      10
---------------------------------------------------------------------------
  228-  247 (31.66/22.79)	HNLEQNLVytERWPYFVCLC
  249-  266 (34.08/17.98)	HAYEDGML..ERQEFLMDLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.13|      20|      31|     892|     917|      11
---------------------------------------------------------------------------
  892-  917 (25.13/33.11)	NT.KKFllETDLPRKKLevkhEEPVRI
  925-  945 (31.00/19.82)	NTgAKY..NADVFKKLL....DSPRRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.02|      19|      19|     714|     732|      12
---------------------------------------------------------------------------
  714-  732 (35.56/22.46)	IWSKRIVIEF....SQKP.VEIRF
 1508- 1531 (27.46/15.70)	IWSKTDPVNVtainSQDPdTKYRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.58|      19|      22|      69|      87|      14
---------------------------------------------------------------------------
   69-   87 (33.49/22.15)	VWNAKVPRLNKLDETMSRG
   94-  112 (31.09/20.02)	VMNRKAELNANLDKERKRG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05245 with Med12 domain of Kingdom Metazoa
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