<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05238

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMLLLYIFLLIPISSIHETIKKSCFEHYVLFVCDKSQFIGFYENEQLSIIDVFYNNNYEADERTFVTVTGQGSYAETNHFEVVKPNDENSLNNQILNIIKMPKRNGTITYHTILVDMIHTVDLSDIKIFTNYPTIVLFIGSELQDIKKTKIVLKMLELESLNNLKILSIVFNNQYMKIAKFLTDDINDNFLYNVTDQKRYDKVNKWILEKICYESGEVTTVTTTPTFISTITHSPSTFTTSQKPKKCNNYLIFAIDTTSNILNIDEFTFMKTTLEYNVSLLITDIKKVAIDSFDIKYNRRYNFNDIKTVEEFMMNIYIIKQRNDSSLSLLFKRMNTLHIPHDSTLSTFIFIAQNDKKEIEKSVVDGKILKNKGSLNFIMMKSNITRDDLSLLHPSNTFRWNLTSSIMSDDSNYSDDSSSDTKDEGGKYISNDKLSGGLKRKWNSEGGDSKNRNMKDMELEELLSDLPVVSHQQHNHGMIPFGMLLQFASHKISQELIVLSELIPKAYDQSKKISLVEFSFVTMNLFSKILAIVKWYTYFKKYRLCTPIQNFLDLQSQIFRDTADALCGIARVELAGARLPYFEMQAALNNIWGEHNILPLAIKKRFVPDPPISSGEQPIILSKLNQVLKNRLSLISSKIPVSITEITIKNGTATFKVIGEYEVTLTLLSAEVAAKWTILHIKILVEQHDIGYGTQLVHPLQLHNIHQHLQRLMYESKNPINTMHDFMHKFCLSLQLDVLYCEATQLTRKQYFRKLLIEKYDIEKGELLICYWPNFDDKKRVYPSEYKIRISHSKSPSYRGLRVYHIPYRAGMPQLDTNTGRLSLCTLINTSSSIRANDKLLALKQKLSIVNPMAGSYISGCSIRTIIFPLIEDSKLLDDEYLTFKVNLYTGAYHCSSSFLKPLKNIKELNDALNGIGSIKQIRELINEIRVNLFMEKYSAIIKIHYLIISEITLPEKARKYFSEIKDAKLCVRFHHDLPYYCVFVFVKDTDCSIVISQYTIFKNCRGDFVITPFMYESKKCHANVAKNNVEEVYDVNDYHPIIHFEDEIKDLILTMDMSIRHKRLEEDFMRKGVSLDEFNIKQPYGDTVVNIVNIPSIPLNDSAFFRTIVKIRMLCDNRIKVLWPFECTVRNVPIISDFFEYTSSDEFPVYLYGKKNLYILNRSSSSLYVTNANIDIVSTNFIEKMTTFAMMYKQIEHFSHSYYNFYRRYCNIKFFSFHKLVIAYGKDRDQLMYLTYKPSRKQYLISFGQDNTRKFSLGYDSNEPSNFTNYINAHNIVSYKLSEMTKKNYFLTELIHYLVNTSDTLTHLYRSIKPVIKSTEIFGQISREMVFFTQEYQLELYCQSEYFFKIVTGTISLGIFIYDSNSVFLKDCSYGEPMLVGLERFIKTQTDGVRVESLFKMTSSERNNYYGASRRVFRLPSIAFKKLTVPHSVEKNYSVLGKYIANIRAFDKLRIIFTQRKEKTIFKGCNIRINHVQRTSYYIKVIYQGAQLPKQINPPTIHFTVYLEPNTFNIKAKIEYDGSIKPPVEAIKKIEEYFEKTLSHGNCPQGVYSFMNILRLTYPTFFSNIAALMNWELNPQPTHFYRLKLDLISNDHRNPDNTVQYSPSFLIEEKSFRVLVPITLRPQKLQKNKNVDSSRIKLNAVWDINKNSFFVHKPSTDLLKSINDKITKQNELTKDSKDCNIESCVRIILTNNFEKLETQK
Length1704
PositionTail
OrganismParastrongyloides trichosuri (Possum-specific nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Parastrongyloides.
Aromaticity0.12
Grand average of hydropathy-0.248
Instability index40.03
Isoelectric point8.89
Molecular weight198349.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05238
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     556.38|     178|     351|     541|     888|       1
---------------------------------------------------------------------------
  693-  887 (287.06/354.25)	TQLVHplQLHNIHQHLQRLMYESKNPINTMHDF......MHKFCLSLQLDvLYCEAtqltrkQYFRK.......LLIEKY........DIEKGELLICYWPNF....DDKKRVypsEYKIRISHSKSPSYRGL..RVYHIPYRAGMPQLDTNTGRLSLCTLINTSSSIRANDKLlalkqKLSIVNPMAGSYISGCSIR...........TIIFPLIEDSKLLDDEYLTFKVNL
 1292- 1507 (269.33/108.53)	TELIH..YLVNTSDTLTHLYRSIKPVIKSTEIFgqisreMVFFTQEYQLE.LYCQS......EYFFKivtgtisLGIFIYdsnsvflkDCSYGEPMLVGLERFiktqTDGVRV...ESLFKMTSSERNNYYGAsrRVFRLPSIAFKKLTVPHSVEKNYSVLGKYIANIRAFDKL.....RIIFTQRKEKTIFKGCNIRinhvqrtsyyiKVIYQGAQLPKQINPPTIHFTVYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.99|      16|      19|     109|     126|       2
---------------------------------------------------------------------------
  109-  126 (24.40/21.53)	YHTILvdMIHTVDLSDIK
  131-  146 (28.59/17.89)	YPTIV..LFIGSELQDIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.88|      37|     233|     968|    1045|       4
---------------------------------------------------------------------------
  167-  205 (59.53/24.24)	SIVFnNQYMKIAKFLTDDINDNFLY.......NVTD...QKRYDkVNKW
  992- 1038 (56.35/10.94)	SIVI.SQYTIFKNCRGDFVITPFMYeskkchaNVAKnnvEEVYD.VNDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.95|      15|      20|    1222|    1236|       5
---------------------------------------------------------------------------
 1222- 1236 (27.64/19.33)	IAYGKDRDQLMYLTY
 1245- 1259 (27.31/19.00)	ISFGQDNTRKFSLGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.26|      17|      19|     274|     292|       7
---------------------------------------------------------------------------
  274-  292 (24.10/17.23)	EYNVSLLITDIKkvAIDSF
  295-  311 (31.15/16.58)	KYNRRYNFNDIK..TVEEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.08|      18|      19|     407|     425|      10
---------------------------------------------------------------------------
  407-  425 (27.47/22.62)	SDDsNYSDDSSSDTKDEGG
  429-  446 (32.61/21.80)	SND.KLSGGLKRKWNSEGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.59|      11|      19|    1188|    1198|      11
---------------------------------------------------------------------------
 1188- 1198 (21.74/12.25)	FAMMYKQIEHF
 1205- 1215 (22.85/13.28)	FYRRYCNIKFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.86|      20|      20|     918|     937|      13
---------------------------------------------------------------------------
  918-  937 (34.10/24.32)	IKQIREL.INEIRVNLFMEKY
  940-  960 (29.75/20.13)	IIKIHYLiISEITLPEKARKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.65|      52|     467|    1047|    1108|      14
---------------------------------------------------------------------------
 1047- 1108 (65.60/88.37)	EIKDLIlTMDMSIRH.....KRLEEDFmRKGVSldEFNIkqPYGdtVVNIVNIpsIPLNDSAFFRTI
 1513- 1569 (91.05/69.84)	NIKAKI.EYDGSIKPpveaiKKIEEYF.EKTLS..HGNC..PQG..VYSFMNI..LRLTYPTFFSNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05238 with Med14 domain of Kingdom Metazoa
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