<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05238

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMLLLYIFLLIPISSIHETIKKSCFEHYVLFVCDKSQFIGFYENEQLSIIDVFYNNNYEADERTFVTVTGQGSYAETNHFEVVKPNDENSLNNQILNIIKMPKRNGTITYHTILVDMIHTVDLSDIKIFTNYPTIVLFIGSELQDIKKTKIVLKMLELESLNNLKILSIVFNNQYMKIAKFLTDDINDNFLYNVTDQKRYDKVNKWILEKICYESGEVTTVTTTPTFISTITHSPSTFTTSQKPKKCNNYLIFAIDTTSNILNIDEFTFMKTTLEYNVSLLITDIKKVAIDSFDIKYNRRYNFNDIKTVEEFMMNIYIIKQRNDSSLSLLFKRMNTLHIPHDSTLSTFIFIAQNDKKEIEKSVVDGKILKNKGSLNFIMMKSNITRDDLSLLHPSNTFRWNLTSSIMSDDSNYSDDSSSDTKDEGGKYISNDKLSGGLKRKWNSEGGDSKNRNMKDMELEELLSDLPVVSHQQHNHGMIPFGMLLQFASHKISQELIVLSELIPKAYDQSKKISLVEFSFVTMNLFSKILAIVKWYTYFKKYRLCTPIQNFLDLQSQIFRDTADALCGIARVELAGARLPYFEMQAALNNIWGEHNILPLAIKKRFVPDPPISSGEQPIILSKLNQVLKNRLSLISSKIPVSITEITIKNGTATFKVIGEYEVTLTLLSAEVAAKWTILHIKILVEQHDIGYGTQLVHPLQLHNIHQHLQRLMYESKNPINTMHDFMHKFCLSLQLDVLYCEATQLTRKQYFRKLLIEKYDIEKGELLICYWPNFDDKKRVYPSEYKIRISHSKSPSYRGLRVYHIPYRAGMPQLDTNTGRLSLCTLINTSSSIRANDKLLALKQKLSIVNPMAGSYISGCSIRTIIFPLIEDSKLLDDEYLTFKVNLYTGAYHCSSSFLKPLKNIKELNDALNGIGSIKQIRELINEIRVNLFMEKYSAIIKIHYLIISEITLPEKARKYFSEIKDAKLCVRFHHDLPYYCVFVFVKDTDCSIVISQYTIFKNCRGDFVITPFMYESKKCHANVAKNNVEEVYDVNDYHPIIHFEDEIKDLILTMDMSIRHKRLEEDFMRKGVSLDEFNIKQPYGDTVVNIVNIPSIPLNDSAFFRTIVKIRMLCDNRIKVLWPFECTVRNVPIISDFFEYTSSDEFPVYLYGKKNLYILNRSSSSLYVTNANIDIVSTNFIEKMTTFAMMYKQIEHFSHSYYNFYRRYCNIKFFSFHKLVIAYGKDRDQLMYLTYKPSRKQYLISFGQDNTRKFSLGYDSNEPSNFTNYINAHNIVSYKLSEMTKKNYFLTELIHYLVNTSDTLTHLYRSIKPVIKSTEIFGQISREMVFFTQEYQLELYCQSEYFFKIVTGTISLGIFIYDSNSVFLKDCSYGEPMLVGLERFIKTQTDGVRVESLFKMTSSERNNYYGASRRVFRLPSIAFKKLTVPHSVEKNYSVLGKYIANIRAFDKLRIIFTQRKEKTIFKGCNIRINHVQRTSYYIKVIYQGAQLPKQINPPTIHFTVYLEPNTFNIKAKIEYDGSIKPPVEAIKKIEEYFEKTLSHGNCPQGVYSFMNILRLTYPTFFSNIAALMNWELNPQPTHFYRLKLDLISNDHRNPDNTVQYSPSFLIEEKSFRVLVPITLRPQKLQKNKNVDSSRIKLNAVWDINKNSFFVHKPSTDLLKSINDKITKQNELTKDSKDCNIESCVRIILTNNFEKLETQK
Length1704
PositionTail
OrganismParastrongyloides trichosuri (Possum-specific nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Parastrongyloides.
Aromaticity0.12
Grand average of hydropathy-0.248
Instability index40.03
Isoelectric point8.89
Molecular weight198349.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05238
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     556.38|     178|     351|     541|     888|       1
---------------------------------------------------------------------------
  693-  887 (287.06/354.25)	TQLVHplQLHNIHQHLQRLMYESKNPINTMHDF......MHKFCLSLQLDvLYCEAtqltrkQYFRK.......LLIEKY........DIEKGELLICYWPNF....DDKKRVypsEYKIRISHSKSPSYRGL..RVYHIPYRAGMPQLDTNTGRLSLCTLINTSSSIRANDKLlalkqKLSIVNPMAGSYISGCSIR...........TIIFPLIEDSKLLDDEYLTFKVNL
 1292- 1507 (269.33/108.53)	TELIH..YLVNTSDTLTHLYRSIKPVIKSTEIFgqisreMVFFTQEYQLE.LYCQS......EYFFKivtgtisLGIFIYdsnsvflkDCSYGEPMLVGLERFiktqTDGVRV...ESLFKMTSSERNNYYGAsrRVFRLPSIAFKKLTVPHSVEKNYSVLGKYIANIRAFDKL.....RIIFTQRKEKTIFKGCNIRinhvqrtsyyiKVIYQGAQLPKQINPPTIHFTVYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.99|      16|      19|     109|     126|       2
---------------------------------------------------------------------------
  109-  126 (24.40/21.53)	YHTILvdMIHTVDLSDIK
  131-  146 (28.59/17.89)	YPTIV..LFIGSELQDIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.88|      37|     233|     968|    1045|       4
---------------------------------------------------------------------------
  167-  205 (59.53/24.24)	SIVFnNQYMKIAKFLTDDINDNFLY.......NVTD...QKRYDkVNKW
  992- 1038 (56.35/10.94)	SIVI.SQYTIFKNCRGDFVITPFMYeskkchaNVAKnnvEEVYD.VNDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.95|      15|      20|    1222|    1236|       5
---------------------------------------------------------------------------
 1222- 1236 (27.64/19.33)	IAYGKDRDQLMYLTY
 1245- 1259 (27.31/19.00)	ISFGQDNTRKFSLGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.26|      17|      19|     274|     292|       7
---------------------------------------------------------------------------
  274-  292 (24.10/17.23)	EYNVSLLITDIKkvAIDSF
  295-  311 (31.15/16.58)	KYNRRYNFNDIK..TVEEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.08|      18|      19|     407|     425|      10
---------------------------------------------------------------------------
  407-  425 (27.47/22.62)	SDDsNYSDDSSSDTKDEGG
  429-  446 (32.61/21.80)	SND.KLSGGLKRKWNSEGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.59|      11|      19|    1188|    1198|      11
---------------------------------------------------------------------------
 1188- 1198 (21.74/12.25)	FAMMYKQIEHF
 1205- 1215 (22.85/13.28)	FYRRYCNIKFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.86|      20|      20|     918|     937|      13
---------------------------------------------------------------------------
  918-  937 (34.10/24.32)	IKQIREL.INEIRVNLFMEKY
  940-  960 (29.75/20.13)	IIKIHYLiISEITLPEKARKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.65|      52|     467|    1047|    1108|      14
---------------------------------------------------------------------------
 1047- 1108 (65.60/88.37)	EIKDLIlTMDMSIRH.....KRLEEDFmRKGVSldEFNIkqPYGdtVVNIVNIpsIPLNDSAFFRTI
 1513- 1569 (91.05/69.84)	NIKAKI.EYDGSIKPpveaiKKIEEYF.EKTLS..HGNC..PQG..VYSFMNI..LRLTYPTFFSNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05238 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA