<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05223

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNDLSQQATVTLSQTPELSNNDLMANENGETMPFGMLLQFMCHKISQELIVISELLPKYTDYNRKITITEFTYMARCLASKILAIVRWLKNYSKHDMCKRIQSFLDSQSQMFRDTADALCTIARNELVFARVPMYEVSTSVALSYGENIKIPIAIKKRFVPEEKISKAERNNILSIINGNIKSRLSLISSLIPPNIQNIRVKNGIVTLVVPGEFELSLTLLNNDANTKWTLLDIKVLVEQYEIGYGTKLVHPMQLYQIHQYLQQMIVHSKNPINDLYKYMHDFSTSLQLDVLFCESSQLASNQLRNKIIIEKYSQETGELVISYWLILKDKKQYVPSQYKIRICKDKNKPNNKLLVRHYPYIRGAPTLNFNTGRLSMSKLLCEISSMRIVEKLKELKTKLLKIKPLCECIFHDDLHPYISFNLLPSNNMNEDSIMNIYVNTFTGNVTCQMYEDDKNVQVFNDKINRNCNNIDELSVIIRDIKISILMKRYRKIVEKYNLFECSNLVVEEAQSIIHSNHCIVTMLGKKNNESLIFSIKTLDDNNLKINFYICKIANDMCLVRKYNPSNDIMNKRPETIDDILIGMTKNEINKNSINEEKTTDSNLITNFQYLESTFNAFINEYMICKVFSRFCNLPDGNAHFNGKRSTGIGAFTNLFTKNSKAEVYKFGKMALSIVDLWTNDIGPYNIYAVTFDIYNTPVKVDFYKRDRNDNHVVLLNGTNKTFVNFKCYKPWIHPFKIFENISESMRLKRHFNFVIYKAMKNFSHYYYKYFKSFCNIKAYTNGSVTIAYGENRNYLLFLSTCKKNIPYALRFGIDSTKSFVNGDNYKGGEEFIKALNPHMYFIHHLEKYFKNEFFMIFLMKYILKTLNSFLIIFNMPVPRCFLGIYSYEFTSMNNKMEIIAPSKISIYDEFTIRLLLGNSTLEIFVGDEDCIYITDGSCQDKKIPGLHSLILTYSYHKKSFNKPFFDYTNEELESFFEIKNMRYKINYSTLRKLCYDIDGENKYPVLPRSHLILRSLAIMILIPMTFMEQLSEVSYL
Length1037
PositionTail
OrganismParastrongyloides trichosuri (Possum-specific nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Parastrongyloides.
Aromaticity0.12
Grand average of hydropathy-0.219
Instability index37.51
Isoelectric point8.91
Molecular weight121095.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05223
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.25|      19|      32|     170|     188|       1
---------------------------------------------------------------------------
  170-  188 (30.21/18.66)	RNNILS.IINGNIKSRLSLI
  202-  221 (26.04/15.06)	KNGIVTlVVPGEFELSLTLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.13|      59|      71|     526|     587|       2
---------------------------------------------------------------------------
  526-  587 (101.14/70.33)	KKNNES.LIFSIKTLDDN.NLKINFY.ICKIANDMClvrKYNPSNDIMN.KRPETIDDILIGMTKN
  597-  659 (88.99/54.70)	EKTTDSnLITNFQYLESTfNAFINEYmICKVFSRFC...NLPDGNAHFNgKRSTGIGAFTNLFTKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.22|      10|      76|     763|     772|       3
---------------------------------------------------------------------------
  763-  772 (22.33/12.87)	FSHYYYKYFK
  842-  851 (20.89/11.57)	FIHHLEKYFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.54|      42|      75|     235|     276|       4
---------------------------------------------------------------------------
  233-  274 (74.85/44.05)	DI..............................KVLVEQYEIGYGTKLV.HPMQLYQIHQYLQQM....IVHSKN.PIN
  275-  352 (43.69/22.95)	DLykymhdfstslqldvlfcessqlasnqlrnKIIIEKYSQETGELVIsYWLILKDKKQYVPSQykirICKDKNkPNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.74|      57|      66|     886|     948|       5
---------------------------------------------------------------------------
  886-  948 (90.78/79.04)	YSYEFTSMNNKMEIIAPSKI.SIYDEFTIRLLLGNSTLEIFvgdedCiYITDGSCQDKKIPGLH
  954- 1011 (99.96/69.47)	YSYHKKSFNKPFFDYTNEELeSFFEIKNMRYKINYSTLRKL.....C.YDIDGENKYPVLPRSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.76|      30|     296|      54|      83|       6
---------------------------------------------------------------------------
   40-   72 (45.35/28.79)	FMCHKISQELIvisELLPKYTDYNRKITITEF....T
   73-  109 (42.41/26.42)	YMARCLASKILaivRWLKNYSKHDMCKRIQSFldsqS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.30|      23|      38|     407|     431|       7
---------------------------------------------------------------------------
  407-  431 (35.57/30.95)	CEcIFHDDLHPYIsFNLLPSNNMNE
  448-  470 (43.73/26.64)	CQ.MYEDDKNVQV.FNDKINRNCNN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05223 with Med14 domain of Kingdom Metazoa
Unable to open file!