<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05216

Description Uncharacterized protein
SequenceMFNSSKTYKVTNWNSELTEKRPIRKASRGRHFDIFPQDSKQDEDNLSSHDRIRKGYIYPQHSYEHESLIFMHKNVKIEPRLDDTIKRAGSFFANVMKKGRTGAIISGKRTLVPKVFQVSEWNYKLPKIFNITQFFEDLSKGKGLYGLIKKFPTFEKNHDFLKYLYEYRVPIVRAIWFIKIVAVFKATHTDDGKQLKKSQALQNALEFVQSIISGYIIHSFKYFYIDGVYEEDKVEKWNYFSLLIKHMCEEGVLDRQDFLTDMIDLLNKYQDFHLDKPQRFKMLFVFVSQFTHYITQNIIISRRMAFLICRRFQRYHYDYMNIAERPITAGEAMNDLLKCENHRPIITSMTGMLYSIITECTQAMPRKNLVYVKRFTGMQVYDELGGSPLDDLTCPFDLMCEEGKLLPPDMIELLKPKIQEIVNRSIDMKYQWHEIISGKTYCSEIINVILNMFEILDNIYILNDEEMEMLNDDLFSCTLEIDKNTELTIRRRMAIHWCITSQRDGAHRVALIVRLLKVHLKKVSNIPTVMMQILNDYLYSEAPKPGNCNFGYEYRNFILFLIDLQTRGILTYKQLLTHWIKEKKIQKDNCLWGKTVKYVYGENYERDFHPIWNKNITMSSRYALQFYRRDSEKHTLLNVDGVTPEERIIIQLPLLPSIQNRNVINYRDKLMYGISIQRNEHINYIKEIAREIINVWKELYYFRIKYSKSRSHFREYYDAQRYYESGDILKRFRMQTYYDQTLITYWVAEDFKEHITGFIDNDTDILPGIDGLDYIMRMFCISMNLSGMIDYCLSLLQLFVKLEDVIITRGYNIIPGYLTKGYAFTITAYLSDNMIYFLNHPKVVDICNALYQNIENNIVLEGYPRTGYEASIAVFISQCKYYLLVYEIASSDDVMGAANDFEKLYPKKFIEVRTDQPRVKIRKLYFAKYLKTSPTFLPYNEIKNLAKHVNNGGLSCRVSFVLTAFNLVKKFGRDINRISALASYCANISALLNLENEWISTIVELLSIPNNTQSMYRGIHKIINVARTTLHYSVSSFILILTARFAFRPHELVAKLIKTNLMFAIRGVYARSKNGYQKVVLAALICTKIVTGYHDPFKLPRGYSGFNDITRPAVRRLGDFKACGVMFSRELDGVIYPLIRLFSTVNRPLKKYRRNRPAKKIRINHFFKACLLFISEQPWFHQKMHKSILNHDGDWQQFKKSLLKNFGVAGILLNYLSRRKGDRRAKLLTLACAENSSKKAFIEKSLASLNIWNFKAVFWDLWGLMTDSTRRPQMKNYPQRIHHCDMLITEIAKGIRDVYVKVSNTFKRHVDFKTDFNFRLECIKNIYLIEEIVNSFPKVWIPRVRSHYHKMKVTTLSAAVLKEFTSIITAKYSKANYATRMEQMSHLLHVTPFLRLLQNVCNKEVEFTYALLQGLYGYLSSLIKDFDSRRLLRPPLVSDKEGVILRVIIVAGMMDQLTRMQTMEPWAILFWQLLYFEVFHPEREEKYYNICYDALTCILFNSAFKIQPRIMSHAFHRARYWTYTQFCKKLKKEGHDRPYPIEKQQLSQLLPLPKRTFDFIVFDHYHKMLEKSKNAYNVSVGNINSIKPYARTGYYPIEKVKLTTFETIQQFFHELLGRKTVNFSFYQAVLADYVPKLSHNLIIRLSFHNHHNLFPKAPIIGDEKDAKLCIMYKHPEAELIEIPKEDKEKIKSMPPRPLMNPSLTNPTIASNPQIAAILAHTPEKPVLSPGSMVKDTHIPLDIKAQHSDMPNIAKEIIHEIEHFQYQSKPPTLIEQGSVSLDAGQPSSMLKQINESPIKQDMMSQQMSQNPLLQQQSTLHNRQIPANNNSQIMQQNIPNINKSSQQYNPPPHHSQKPYNSQDINIGMSGDMNSGIGSNINQNRMQYNDEGPYSRTLSQEPMQTDSLPPVLIPSGSMSKPNRRRANPNQGSGNKTPSKKRKESKPIDVVSPPVLQENIPNINQPQHPMGMRHFDNVPSNPQMPNYNNQSNYGLQGNVGLQNNIPSQPNMPPQPNMPSQGNLAHSQNLIHKNNMPSQGGIPNQGPIQQQPSLQPPINHHNQNVMHPSQERLSNPNNTIPNQNNQLNQNNSIPMNQRNPMNSQQQNPNAFMGSSGPPKLPPQSQNPQRPSQNPLNSMNIPRNTQSGPININNNQQPNSMNMPPTHQQSNPINLPLQQQPTSMNMPPVQNKNQMNMGNPSQGNMIPMQSSQHGNIHNMGNNQMNMPPNVPQNNTISRPNPQQQPPPPYNMTMNQQGASLNVNNNPGSNTIPMQNNMTNNNNIHMGGNQQNNMMNMPSNRQNNMNMPVNHQNTNIPPNQQNSSLGMPSGNQGASSGMQQKTNILQQVLNNPNANQNMQQNMQQNIQQNMQQNMQQNMQQNPQYNKPSGMPNMPQQQPVQQPKTMMGMNNQQQNVPQHVQQNMAPSQMRPNPLPQQTSQQPMQQQNINQKMYGSQGTNSGMSKTMGQNVMGTNPSSFQQQQPPAQQSTSSNMGNNMNTNIPNHLPPQNHMGNTIGSGMPSNINNNMPAPIGNNIVNNMPNNMNNTVHSSMPNQQRMMHPNMMNQSQQQQMTQQRQIQESQSMQQQRPQQMPNQQHQINNPMGNSQQQSIGNSRQQINNSQQSIGGHQQQMVNPQGQISNHQSQIPSHQQHMNPPSQMPPPQQQMNNQQPMMGNPQQQMGNMQQTMGSQQQQMSGHQQPWNMQHSSQNPMQKEIQSMNPGMRQPMNPPMTRDRMGMRAGSEAPLETKKILKDMLKQKNNTNTPMHLSNQQHPQGMVPQQQMNMNNQVHNQGPMMNTYEVNQRQEMLMSELQELMSTKGKNLSDCKRTFVVRDYTDGLNVKFSTEISGLIADRCEKEIWIDFIKNINTKFEEAAAIDARSTFETCLNCCTCYFSTVFFNSKYQKKLNSVMKYIEEKNKTVFIQRNLFVVNPMKKGLRVLEVICLNEFEAPPPQVLNSSIPLVPR
Length2955
PositionKinase
OrganismParastrongyloides trichosuri (Possum-specific nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Parastrongyloides.
Aromaticity0.08
Grand average of hydropathy-0.645
Instability index54.59
Isoelectric point9.46
Molecular weight341629.94
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
membrane	GO:0016020	IEA:UniProtKB-KW

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05216
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            15|     673.76|      37|      37|    2368|    2404|       1
---------------------------------------------------------------------------
 1795- 1830 (34.56/ 6.51)	.SPIK....QD.MMS.Q.QMSQN.PL.....LQ...QQ...S....TLHN.RQ...I..PANNNSQ
 1833- 1869 (37.12/ 7.53)	QQNI........PNI.N.KSSQQ.YN.....PPphhSQ...K....PYNS.QD...I..NIGMSGD
 1998- 2030 (42.18/ 9.56)	QNNIP....SQ.P...N.MPP.Q.PN.....MP...SQ...G....NLAH.SQ...N..LIHKNN.
 2073- 2099 (36.03/ 7.10)	NTIPN....QN.NQL.N.QNNSI.P......MN...QR...N....PM...............NSQ
 2163- 2194 (47.33/11.62)	QSNPI....NL.PLQ.Q.QPTSM..N.....MP.............PVQN..K...N..QMNMGNP
 2217- 2250 (54.44/14.47)	QMNMP....PNvPQN.N.TIS.R.PN......P...QQ...Q....P..P.PP...Y..NMTMNQQ
 2253- 2283 (38.52/ 8.09)	SLNVN....NN.PGS.N.TIPMQ.NN.....MT...NN...N....NIH...........MG.GNQ
 2284- 2323 (43.17/ 9.95)	QNNMM....NM.PS..N.RQNNM..N.....MP..vNH...QntniPPNQ.QN...S..SLGMPSG
 2368- 2404 (79.03/24.32)	QQNMQ....QN.PQY.N.KPSGM.PN.....MP...QQ...Q....PVQQ.PK...T..MMGMNNQ
 2405- 2450 (38.67/ 8.15)	QQNVP....QH.VQQ.NmAPSQMrPN....pLP...QQtsqQ....PMQQ.QNinqK..MYGSQGT
 2516- 2560 (46.95/11.47)	NNNMPapigNN.IVN.N.MPNNM.NNtvhssMP...NQ...Q....RMMH.PN......MMNQSQQ
 2568- 2598 (47.25/11.59)	QIQES....QS.MQQ.Q.RPQQM.PN..........QQ...H....QINN.P........MG.NSQ
 2634- 2668 (50.79/13.01)	QSQIP....SH.QQHmN.PPSQM.PP......P...QQ...Q...mNNQQ.P.......MMG.NPQ
 2699- 2731 (38.40/ 8.05)	QNPMQ....KE.IQS.M.NP.GM.R................Q....PMNP.PM...TrdRMGMRAG
 2743- 2778 (39.33/ 8.42)	KDMLK....QK.NNT.N.TPMHL.SN..........QQ...H....PQGMvPQ...Q..QMNMNNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.76|      47|     149|     221|     271|       2
---------------------------------------------------------------------------
  221-  271 (81.76/62.29)	KYFYIDGVYEEDKVEKWNYFSLLIKHMCEEGVLdrqdFLTDMIDLLN.KYQD
  373-  420 (83.01/53.38)	KRFTGMQVYDELGGSPLDDLTCPFDLMCEEGKL....LPPDMIELLKpKIQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.59|      19|      19|    2118|    2136|       3
---------------------------------------------------------------------------
 2120- 2141 (31.08/ 8.87)	QNPQRPSQNPLNSMNIPrntQS
 2349- 2366 (30.68/ 8.65)	QNMQQNMQQNIQQ.NMQ...QN
 2471- 2488 (31.55/ 9.12)	QQQQPPAQQS.TSSNMG...NN
 2682- 2697 (29.27/ 7.89)	QQQMSGHQQP...WNMQ...HS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.90|      10|      15|     657|     666|       4
---------------------------------------------------------------------------
  657-  666 (19.08/10.81)	SIQNRNVINY
  675-  684 (19.82/11.59)	SIQRNEHINY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     160.03|      39|     150|    1887|    1926|       5
---------------------------------------------------------------------------
 1682- 1712 (34.16/11.27)	...IPK.EDKEKiksmPP...........................RPLMN.........PSL.....TNPTIASNP
 1907- 1949 (64.38/29.08)	PVLIPS.GSMSK....PN...........................RRRANPNQGSGNKTPSKkrkesKPIDVVS.P
 2038- 2058 (28.02/ 7.65)	..................................................PNQGPIQQQPSL.....QPPINHHNQ
 2059- 2118 (33.46/10.86)	NVMHPSqERLSN....PNntipnqnnqlnqnnsipmnqrnpmnsqQQ..NPNAFMGSSGPPK.....LPPQ.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.50|      10|      15|    1954|    1965|       6
---------------------------------------------------------------------------
 1954- 1965 (16.35/10.08)	ENIPniNQPQHP
 1972- 1981 (20.16/ 6.30)	DNVP..SNPQMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.23|      10|      15|     700|     709|       7
---------------------------------------------------------------------------
  700-  709 (19.26/12.05)	YYFRIKYSKS
  716-  725 (19.97/12.82)	YYDAQRYYES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.36|      11|     109|    1480|    1490|      14
---------------------------------------------------------------------------
 1480- 1490 (21.04/11.18)	HPEREEKYYNI
 1587- 1597 (20.33/10.52)	KPYARTGYYPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.79|      11|      15|     325|     337|      19
---------------------------------------------------------------------------
  325-  337 (15.01/13.60)	RPITAgeAMNDLL
  343-  353 (20.78/11.01)	RPIIT..SMTGML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.18|      13|      19|    2599|    2611|      20
---------------------------------------------------------------------------
 2599- 2611 (23.22/11.34)	QQSIGNSRQQINN
 2620- 2632 (24.96/12.91)	QQQMVNPQGQISN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.50|      46|     214|    1303|    1351|      22
---------------------------------------------------------------------------
 1303- 1351 (81.19/54.52)	SNTFKRHVDFK.TDFNFRL..ECIKNIYLIE..EIVNSFPkvwIPR......VRSHYHKM
 1512- 1568 (70.31/39.24)	SHAFHRARYWTyTQFCKKLkkEGHDRPYPIEkqQLSQLLP...LPKrtfdfiVFDHYHKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.80|      15|      15|     771|     785|      24
---------------------------------------------------------------------------
  771-  785 (28.67/20.01)	GL.DYIMRMFCISMNL
  787-  802 (22.13/13.38)	GMiDYCLSLLQLFVKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.33|      13|      19|     281|     293|      27
---------------------------------------------------------------------------
  281-  293 (24.18/16.05)	KMLFVFVSQFTHY
  303-  315 (25.15/17.04)	RMAFLICRRFQRY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05216 with Med12 domain of Kingdom Metazoa
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