<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05215

Description Uncharacterized protein
SequenceMIDKKFRDELISKREHVELLYSFQGSKIGRGTYGHVYKATPRFETPENKGKTYAIKLIDGNGFSMSSCREIALLRELSHPNLIKLNRVFLSSERKVWLLFDYAEHDLWHIIKFHRNAKQRKQAVMVPKSMVKSLLFQILDGIHYLHTNWILHRDLKPANILVVGDDPYERGRVKVADMGFARTFHSPVRPMADLDPVVVTFWYRAPELLLGAKHYTKAIDIWAIGCIFAELLTSEPIFFCREEDIKASSPYHKDQLNRIFQVMGYPQEADWPDLKKMPEYQRLLKDFKKQLFSECTLYRYLDKHKIKTNNKGFNLLQKLLTFDPMKRISAIDAINDPYFQESPKPTQDVFRGGPIPYPRREFMQDENEEKILNKQITQQNVPVQQHMSNNISTNKIVQQTNNQMIHTSESVIKPNQYQNMTSQSDYEYRRNHSGNINQTPNQQMGVFNNRNQQNQYMQQQMFANNDPNRNVPQQPTHQESTRAPGRQYLNQQQYHVNPQDNNRMMVQQNQHQMHQKQQQNQMMMQQQNRFVQNQEQTNMVQMQHPHIQQPYPQQPQQHQMQTQQQIMHQQNLMWKQQQQQQQQQQHQQQRYQ
Length592
PositionKinase
OrganismParastrongyloides trichosuri (Possum-specific nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Parastrongyloides.
Aromaticity0.09
Grand average of hydropathy-0.964
Instability index52.24
Isoelectric point9.45
Molecular weight70533.29
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05215
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.48|      15|      17|     556|     570|       1
---------------------------------------------------------------------------
  502-  517 (25.87/ 8.01)	NRMMVQQ.....NQHQMhQKQ
  564-  583 (23.61/ 6.70)	QQIMHQQnlmwkQQQQQ.QQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     110.53|      18|      18|     442|     459|       2
---------------------------------------------------------------------------
  403-  418 (22.18/ 8.49)	QMIHTSESVIKP...NQ....Y..Q
  422-  442 (19.92/ 6.65)	SQSDYEYRRNHSgniNQ....TPNQ
  443-  459 (29.46/14.42)	.QMGVFNNRNQQ...NQ....YMQQ
  477-  491 (19.62/ 6.41)	HQE...STRAPG...RQ....YLNQ
  525-  542 (19.36/ 6.20)	QQ....QNRFVQ...NQeqtnMVQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.49|      14|      22|      69|      82|       3
---------------------------------------------------------------------------
   69-   82 (23.01/13.75)	REIALLRELSHPNL
   94-  107 (25.48/15.88)	RKVWLLFDYAEHDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.53|      16|      18|     364|     379|       5
---------------------------------------------------------------------------
  364-  379 (26.09/16.79)	QDENEEKILNKQITQQ
  384-  399 (27.44/18.05)	QQHMSNNISTNKIVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.62|      17|      22|     207|     223|       9
---------------------------------------------------------------------------
  202-  221 (25.14/20.61)	WY...rapELLLGAK.HYTKAIDI
  222-  245 (21.48/16.44)	WAigcifaELLTSEPiFFCREEDI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05215 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ESPKPTQDVFRGGPIPYPRREFMQDENEEKILNKQITQQNVPVQQHMSNNISTNKIVQQTNNQMIHTSESVIKPNQYQNMTSQSDYEYRRNHSGNINQTPNQQMGVFNNRNQQNQYMQQQMFANNDPNRNVPQQPTHQESTRAPGRQYLNQQQYHVNPQDNNRMMVQQNQHQMHQKQQQNQMMMQQQNRFVQNQEQTNMVQMQHPHIQQPYPQQPQQHQMQTQQQIMHQQNLMWKQQQQQQQQQQHQQQRYQ
341
592










Molecular Recognition Features






MoRF SequenceStartStop




1) QHQQQ
585
589