<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05211

Description Uncharacterized protein
SequenceMSFQPKQYKMVHWSSNDNLPEKRLIRKNSKGRCFDVFPQDTLQDEDNISSIDRIRKGFIIDVRSYEHDSFLINSQKNNSFGKTLENTTTKAFQFFDNIIKKKCLDISKNNKKNIFQKLFQVTDCNYKFSKTYTIQQFFEDLCKGKDSFGLLKKFPYFENKDNFLKYLFNYRVPISKAIWFIKIMAIFKATQFEDGKAPKKSQVQQAALEYVQTLISGYIIHTFKYFHSNNESIEEKIERWNYYALLIKHMFEEGVLDRQDFLTDMIDLLNEYIDFPLDGPTRFKLLFIFTSQFSSFITQNIILSRRMAFVICRRFRKYHFDYMNIMGDFIDCGTTINELLKCEHHRPLILSMVGILCCILTECIQAITYKYIHVDRKFCGIKWFDDLTSTPLEYLTCTFDIICEGTGRMSLESISRIKDKINEFTERSIDLKYMLHSVITGQEDCSDVTMMILNMFDALDTIYICNEQELKNIYEYIFTHKTHMKEKTEVIIKLRLLIHWCITSQRYGTERAAIVSKLLLIHFRTTKISSTKNMIEILNDYINTECPSPGYCNYGYEFRNFIHFLNTLQDYNLLSYKELLKNWIKRKKINPEDCLWRKTMKYVYGENYERDLNPSWNKYTQMSSRYALQFYRRDSEKHILINLEDVNIEERIFLQMPLLPSIKNRDDIIYRENIIYGSITRVWKKLYFFKIKHNSNGVDFHEYHDFDKYLKSGDILMKFRRQTYFDQTLITYWVGYDFRDYLKSYIVNETSRLPGSDGLDYILRMFCISMNICGMIEFIDELLIYISKLEDIMIERRYNMIPGMLTKSYSFTIVGYLSEHFSYFLQHPKAPSVINGLYSTIENTIVLKGYPRTGYDMNIAMFIYYSKYILAAEEMYNVSSLGGSVKDIEKLYPLPYIEIKTDQTKIKPKKLYFGKYLKTTPQMLSHSELQKMTKDINEGGINSRLSFVLASLQAAKNLGRDINKLTLLGNYVANVSVHLRLENEWMSVILEMCSLTTNPNTIYKGVHRTVNIGRTVQHYPLSTFIMILAAKYVIRPRDLIYTLTKNTMISVFKGTYLKSKFGYEKVILAALICTKILTGYHDPFKLPKGYTGLQEIKRPDIRRLADFKACAVLSFKEINDVLYSFIKLLSLANRPIKNVQKKRPGKRIRINHFFKACLLCISEQNWFYQKISLCIYQPTDELIKDNFLNSNGLCGTLLKFISRSKADRQVKLQILSNTEKLTHKDFIEKTLDTLNIYNFKSVYWSLYGLLNDTERKLKDKNYAQKIFNSNHVMKCIAEGIKNMFLKPSNIYGENIFFKSDSFFRLKNISKLWLLKHLIDDFPKINIPQNDYKKSKISVMPLSQAVLIEFTYFLTESYSKIEYIKRTEQFSYILRSTPFVEILQSCANENLTHTHALLQGFYSYLTNIIKEFDSRRILSSQLINEKNGIRLRIIIISGLMEQLLTMPAIEPWAYLLWQLLYLEIIHPEKXCYMICYEALSTILFMSAFKVQPRQNEGIHHRARYWAYNHFCKRLRRECQDRPFPSNKKQLEQLLPLPKRTFDYIIFDNYYKLIAKADNVLEVEGNTSEVIKLVKRTGYYPVEKIKLTTFEVIPGFFHESLGRKTVNFWFYQANILDYSPRIDYNMIINLSYHNHRNIFPRAPIYGENKALKENFVYLQPSIEFNVTKEERPSLDNTKTKLINNSVVSPKIVNVPDKNNTFPIQNIQNGSNNVSKQSSNTTLKPLQINGEIIDPSRPQFNPIQQNIIPPSSQVPVQYQQNPMSDVLNYNYQQPNQMPKVQKRKTNTSEITKTPIKKRKDVSDVIPPPMGSNNMINPRSVMTQQNIIPQQNVLPHLQNVQTKMLPPNPPTNNVYQQMNKNQGIPQHDINSTKSMIYSNNEQSAINPMRQNNTDQRMFEQMRSNQNPQGYILPQQTRSILQQNERSNYMEKFDNQNKHNNMLKEMLQQKNPQPSQMMPPQYSQPINNPNINQKTQFTQQQRDMLYYNSQQQQQHNQIPYQDSNMGRINQQHPNKPQQYNQQYMYPR
Length2022
PositionKinase
OrganismParastrongyloides trichosuri (Possum-specific nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Strongyloididae> Parastrongyloides.
Aromaticity0.12
Grand average of hydropathy-0.455
Instability index48.14
Isoelectric point9.27
Molecular weight238633.89
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05211
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     341.51|      41|      41|    1835|    1875|       1
---------------------------------------------------------------------------
 1674- 1709 (43.86/19.05)	NTK.TKLIN..N..SVVSPKIVNV...P.DKNNTFPIQNI..QN...G.....SN
 1759- 1795 (31.52/11.43)	........P..M..SDVLNYNYQQ...P.NQMPKVQKRKT..NTseiTKTPIKKR
 1797- 1834 (43.82/19.03)	DV..SDVIP..P..PMGSNNMINPrsvM.TQQNIIPQQNV..........LPHLQ
 1835- 1875 (72.36/36.67)	NVQ.TKMLP..P..NPPTNNVYQQ...M.NKNQGIPQHDI..NS...TKSMIYSN
 1876- 1919 (47.34/21.21)	NEQ.SAINPmrQ..NNTDQRMFEQ...M.RSNQN.PQGYIlpQQ...TRSILQQN
 1923- 1945 (32.74/12.18)	NYM.EKF.......................DNQN..KHN...NM...LKEMLQQK
 1946- 1983 (46.87/20.92)	NPQpSQMMP..PqySQPINN..PN...I.NQKTQFTQQQ.........RDMLYYN
 1987- 2017 (23.00/ 6.16)	QQQ.HNQIP.yQ..DSNMGRINQQ...HpNKPQQYNQQ.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.07|      28|      51|     863|     890|       2
---------------------------------------------------------------------------
  863-  890 (47.39/32.53)	IYYSKYILAAEEMYNVSSLGGSVKDIEK
  911-  938 (49.68/34.50)	LYFGKYLKTTPQMLSHSELQKMTKDINE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.48|      30|      44|    1097|    1128|       3
---------------------------------------------------------------------------
 1097- 1128 (45.70/37.22)	KRPDIR.RLAD.FKACaVLSFKEINdVLYSFIKL
 1142- 1173 (50.77/31.60)	KRPGKRiRINHfFKAC.LLCISEQN.WFYQKISL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.64|      39|      51|     109|     147|       4
---------------------------------------------------------------------------
  109-  147 (71.88/40.12)	NNKKNIFQKLFQVTDCNYK...FSKTYTIQQF..FEDLCKGKDS
  158-  201 (55.76/29.43)	ENKDNFLKYLFNYRVPISKaiwFIKIMAIFKAtqFEDGKAPKKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.51|      23|      51|      26|      48|       5
---------------------------------------------------------------------------
   26-   48 (41.80/27.21)	RKNSKGRCFDVFPQDTLQDEDNI
   76-   98 (39.71/25.45)	KNNSFGKTLENTTTKAFQFFDNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.29|      41|      51|    1193|    1237|       7
---------------------------------------------------------------------------
 1193- 1230 (44.44/32.36)	...............LCGTLLKFisrsKADRQVKLQILSNTE.KLTH..KDFIEKT
 1231- 1266 (32.78/15.40)	LDTLNIYnfksvywsLYG..................LLNDTErKLKD..KNYAQKI
 1285- 1321 (51.06/28.29)	LKPSNIY..........GENIFF....KSDSFFRLKNISKLW.LLKHliDDF....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.59|      30|     266|     264|     297|       8
---------------------------------------------------------------------------
  264-  297 (49.89/33.80)	DMIDLLNEYIDFPLDGPTRFKllfiFTSQFSSFI
  533-  562 (59.70/31.93)	NMIEILNDYINTECPSPGYCN....YGYEFRNFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.23|      20|     102|    1484|    1507|      10
---------------------------------------------------------------------------
  223-  243 (33.68/15.83)	FKYFHSNNESIEEKIERWNyY
 1487- 1506 (39.56/22.86)	FKVQPRQNEGIHHRARYWA.Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.24|      36|      40|     770|     809|      11
---------------------------------------------------------------------------
  770-  809 (54.48/44.27)	MNICGmieFIDELLIYI...SKLEDImIERRYNMIPG.MLTKSY
  811-  850 (53.76/31.16)	FTIVG...YLSEHFSYFlqhPKAPSV.INGLYSTIENtIVLKGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.15|      27|     680|     736|     765|      18
---------------------------------------------------------------------------
  704-  731 (44.72/25.91)	HDFDKYLKSgDILMKFRR...QTYFDQTLIT
  736-  765 (43.43/33.63)	YDFRDYLKS.YIVNETSRlpgSDGLDYILRM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05211 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KNNTFPIQNIQNGSNNVSKQSSNTTLKPLQINGEIIDPSRPQFNPIQQNIIPPSSQVPVQYQQNPMSDVLNYNYQQPNQMPKVQKRKTNTSEITKTPIKKRKDVSDVIPPPMGSNNMINPRSVMTQQNIIPQQNVLPHLQNVQTKMLPPNPPTNNVYQQMNKNQGIPQHDINSTKSMIYSNNEQSAINPMRQNNTDQRMFEQMRSNQNPQGYILPQQTRSILQQNERSNYMEKFDNQNKHNNMLKEMLQQKNPQPSQMMPPQYSQPINNPNINQKTQFTQQQRDMLYYNSQQQQQHNQIPYQDSNMGRINQQHPNKPQQYNQQYMYPR
1695
2022










Molecular Recognition Features






MoRF SequenceStartStop




NANANA