<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05195

Description Cyclin-dependent kinase 8 (inferred by orthology to a C. elegans protein)
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
Length583
PositionKinase
OrganismNippostrongylus brasiliensis (Rat hookworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Trichostrongyloidea> Heligmonellidae> Nippostrongylinae> Nippostrongylus.
Aromaticity0.09
Grand average of hydropathy-0.689
Instability index62.99
Isoelectric point8.69
Molecular weight67552.09
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05195
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.69|      20|      20|     478|     497|       2
---------------------------------------------------------------------------
  415-  435 (28.74/ 7.95)	QMNansqpMF..SGGDF.HQPM...QP
  442-  466 (30.19/ 8.69)	SMD..mggMMnqQQQQYQQQPIFASQP
  478-  497 (48.01/17.80)	QMN.....MM..QGQQFQHQGMMHAQP
  559-  572 (29.75/ 8.47)	Q...........QQQQQQQQQ..QQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.24|      19|      37|     499|     518|       3
---------------------------------------------------------------------------
  499-  518 (36.32/20.25)	MMrQQMPSSFQQHPQGMMQQ
  524-  536 (27.56/10.35)	DM...MP.NMQ...TGMQHQ
  540-  556 (35.36/15.48)	GM.QNMTG..NPPPYAMMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.00|      31|      37|     122|     157|       4
---------------------------------------------------------------------------
  122-  157 (49.50/54.72)	VPVMVPKGMVKSILYQILD.GIHYLHSNwvlhrDLKP
  160-  191 (50.50/39.11)	ILVMGDAPGVHRGRVKIADmGFARIFYN.....PLKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     131.50|      32|      32|     296|     327|       5
---------------------------------------------------------------------------
  240-  270 (35.59/18.19)	...FCKEEDIKAQ..SPyHYDQLKRIFTvMGY...PQ...ES
  278-  299 (23.08/ 9.35)	MPDY...HKLQTDikSS.Q.............tafPN...CS
  300-  332 (49.78/28.20)	MTRYMEKHKIESD..SP.QFKLLVKLLT.MDP.....nkrIS
  333-  346 (23.05/ 9.33)	CKDAMEE.........P.YFK........MDP..........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05195 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PDADIKKSLAMNIVDDQNQQATNPQVNQAMNQQLDSEPVNKRLRMGGQQMNANSQPMFSGGDFHQPMQPQHMISQSMDMGGMMNQQQQQYQQQPIFASQPMPASMPVSGQQQMNMMQGQQFQHQGMMHAQPMMMRQQMPSSFQQHPQGMMQQPGGGVDMMPNMQTGMQHQQVQGMQNMTGNPPPYAMMQQQQQQQQQQQQQQQQQPPQQQQAWNNYQ
367
583










Molecular Recognition Features






MoRF SequenceStartStop




1) PPPYAMMQQQ
2) QQQQQQQPPQQQQAWNNYQ
548
565
557
583