<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05169

Description Uncharacterized protein
SequenceMSAKTSKVLSWYQSTADKRTLRRHKIGPPDVHPQEPRQEEDNLSNERLRKGYQVGATPFEHESLVFNSRSAKLDRLDEAHAKSTALLNFVLHRKGEINANLDKERRKNRETAGAQFVATKTKERAVWFTDLARGKALSQLAKKVPTIKRQDGLEYLCDYRIPPFRALWYLKVTAALTGSSNTTKQKKSISDLFSAEYKEIFVKAIKDLTGRMWCVNDLSTCPIYKERWLYISNLSKIAFEDGVIERQDFLNELCDIFSDYFVRRVKNEEKLPQLRVYLMFLTQFLRHINNNLILARRLAHMIAMKLRLYKMEYDEQNNTITKGAEAFIALTQCSAYRPVIHVLIAILQNIVIDAPAAVIWNKFKVSTTDKLPFILSQLCGSPLDLLPCAVHELPLTPGKDSERFSELLKLRTAEIVRRSQAVQDKWSFNQKEQFAFAKLVNGCLDVIGILDSTDVFEPNVLSTVTKRLFNFQSENWAEDVLIRMKLMLHWAVTAEREGSHRAVIVTKVIYNQVLQQQSYMFGPFHMQDIILNYFYTEAPTVGSKYYHQEFASLVTLFIELSRFKLFVHDCFVKELIKSGELDYQRPVMDKYKSENKATDVISSSLISAQFEDLTPDEPPKPSSLISFRQDEKDEHIYLNDPMSVNDRILIQMPLRQTEEHRSEANQRALVLYGMDDVRENHKAEMKKIAKEICKIWQKKICVVFSEGNEVPLWKQSINSQKIVEILARFRSQTYYDQMMICGWCAESFSDMIRDFVLGHSLQMPTSEGLDIICGMFEAAQYIYGIFELCEAVTPMLLSAEKVIRSLAADVIPGSMSGQLGYVFVAYISRHWHYFLHSDLAPVITNQLYELIERMIRAHEYPVTSWGRTIAAFVYHSKCQLKKSQLSPIKLHGAHDDFRHVFNHGSSSYNGGCRYNALFFTDVFEKKLRFFSYHEYKKRLPSFGQLYNRYSFVINSFIAAKNCMRDHDRLADLAAFCGHISAQIPALADEWVAAIKALCCTSVSQHTGYGELLAHIDINDCSTHYPLATFVLLLAGKYAFSVPRLIAELLNNAFPVVMKREQSSFVSGRYNVLGRSEYDCEPGACLTLLILAQISCATDEPYHLSEHYVGTNPKVKLLPKCADEHILSMIHWCEMDSVLFPMLSNICILMDTLRGRFKDLDFEPSRIIDSTNYRREYLMILLKATQSVICEEDWVTLKMFRIVETNRMEAFNHDRLKQNCLGQQLLRMGIRRRSEREVLRELSVCNGNSKKALIDKLLAVMNMWNMRATLFDLMLMIKEISPEGAQKHAQQSAIAADALMGEIGKCCRDLFTNAHKEGIQLPPAILGRDFRFRHVTNFWLIASLVRLCPQPSNVPNQFHHMTVSGKFLKEAASMLDTANDSSKERIQQSAWLLSQQPFLNLVLACLKGENFQPNKDMLVSSLYKQLLDLTSKTKENPALPLMKKFSAEREALLLRLSLVGGIFKQVSDN
Length1468
PositionKinase
OrganismHaemonchus placei (Barber's pole worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Trichostrongyloidea> Haemonchidae> Haemonchus.
Aromaticity0.10
Grand average of hydropathy-0.203
Instability index42.56
Isoelectric point8.62
Molecular weight168589.09
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05169
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     211.54|      57|     486|     360|     457|       1
---------------------------------------------------------------------------
  374-  431 (92.20/81.61)	ILSQLCGSPLDLLPCAVHE..LPLTPGKDSERFSELLKLrTAEIVRRSQAVQDKWSFNQK
 1343- 1395 (82.25/44.68)	.LVRLCPQPSN.VPNQFHH..MTV.SGKFLKEAASMLD..TANDSSKERIQQSAWLLSQQ
 1417- 1455 (37.08/42.09)	LVSSLYKQLLDLTSKTKENpaLPLMKKFSAEREALLLRL.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     288.11|      95|     486|     513|     636|       2
---------------------------------------------------------------------------
  513-  621 (141.77/129.28)	VLQQQSY..MFGPFHMQDIILNY.FYTEAPTVGSKYyhqEFaSLVTLFIELsrfklfVHDCF..VKELIKSGELDYQRPVMDK..YKSENKATDVIsssLISAQFEDLTpDEPPKP
 1002- 1103 (146.34/93.38)	VSQHTGYgeLLAHIDINDCSTHYpLATFVLLLAGKY...AF.SVPRLIAEL......LNNAFpvVMKREQSSFVSGRYNVLGRseYDCEPGACLTL...LILAQISCAT.DEPYHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.78|      31|     486|     195|     263|       3
---------------------------------------------------------------------------
  122-  158 (50.61/63.19)	KERAVWFTDlargkaLSQLAKKVPTIKRQDGLEYLCD
  225-  255 (57.18/38.83)	KERWLYISN......LSKIAFEDGVIERQDFLNELCD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     296.05|      90|     306|     901|     999|       6
---------------------------------------------------------------------------
  901-  999 (147.54/138.64)	FNHGSSSYNggCRYNALFFTDVfekklRFFSYHEYKKRLPSFGQlyNRYSFVINSFIAAKNCMRDHDRLADLAAFCGHIS.......AQIPALADEWVAAIKALCC
 1210- 1306 (148.52/112.53)	FNHDRLKQN..CLGQQLLRMGI.....RRRSEREVLRELSVCNG..NSKKALIDKLLAVMNMWNMRATLFDLMLMIKEISpegaqkhAQQSAIAADALMGEIGKCC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.56|      26|     190|      86|     120|       7
---------------------------------------------------------------------------
   42-   58 (18.43/ 6.84)	..............NLSNERlRK.....GYQVGATP
   86-  120 (35.23/46.68)	LLNFVLHrkgeINANLDKER.RKnretaGAQFVATK
  281-  297 (22.90/10.37)	LTQFLRH....INNNLILAR.R..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.65|      16|     432|     884|     900|      11
---------------------------------------------------------------------------
  884-  900 (26.74/19.75)	QLSPIKLhGAHDDFRHV
 1319- 1334 (31.91/18.38)	QLPPAIL.GRDFRFRHV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05169 with Med12 domain of Kingdom Metazoa
Unable to open file!