<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05164

Description Mediator of RNA polymerase II transcription subunit 13
SequenceLQMRFEIHEKLSGEGFYQRSVLFLRERCELFGWLKCMHSAPGNIVEGPLTWRALTSKSLPKSSAPTHDDDISLPEPIPYINVAAEKDAIRAAPHVVRHWEHLSLGPIDQPKDVLYLVVVPDNPDICNLAVKYLEQLSQMYERMRLGRHIAMPTGVDSRDGCVRVGCRTQTGKYPTETTTLDFLNLVGRYVDNKAFMTKLRLFTQQMEENVLQLLSERDDIFERATYRETLALDWRAKRAAAAAVALAVEQRMAENSAEQGASVAAPEQPPAEPPLEPEDIPVDEPGTLPHVIVIYVLNPFTWGTEFRSALFTRVATLAVMRAFNTVCLRLPANRRPQLQLEIIPMEQVTDLLGCLPDYTNDNGSSQSMFENSGGSEREQVECVAVESLRNTVLSVYTQPRVLTADCIKSVQARCMTKFGPGSSLLDSLDEWERSGTTVFYKVPSNAYHLAPPPLLYQKHENGRIIQSSPEEQVLYVTYCVIGSDWLCVAVTDSLGRLNDNCLINLRTRHDHHIYKYRQQTQILDAMGRLWTYILGVLSMETRNWRLVIGRLGRIGHGEFKAWTYLLNKTALKRHSARLREVCTACAQMPGCTGTPSILSACLVSTEPEPYLRMFPGFSLNDAYSKKTRSTLPDDTNVTHIMVFPTSADIQLGSADQHAVGEDDWDFSDMDIPQDGNDLGDDFLSSICMDNLGPPQPSASFRNAGNSFFSENTADVSMENQPLATGFYISTAPAADVPDWFWASCPGAKNRTPVHLKSSLHINVPLVHQGDEFLQGKATTGDKQEKESAHPLDSTRTDEVLRHVLETYNALSWLNIDVVSGERRSCLPIHMQALTRLYHSVARLIM
Length845
PositionMiddle
OrganismHaemonchus placei (Barber's pole worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Trichostrongyloidea> Haemonchidae> Haemonchus.
Aromaticity0.08
Grand average of hydropathy-0.289
Instability index46.41
Isoelectric point5.59
Molecular weight94701.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05164
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.27|      35|     200|     399|     434|       1
---------------------------------------------------------------------------
  399-  434 (59.59/36.29)	PRVLTAdCIKSVQARCMTKFGPGSSLLDSLDEWERS
  595-  629 (63.68/34.79)	PSILSA.CLVSTEPEPYLRMFPGFSLNDAYSKKTRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.86|      83|     200|       2|      96|       2
---------------------------------------------------------------------------
    2-   96 (126.10/99.76)	QMRFEIHEKLS.GEGFYQRSVlfLRERCELfGWlKCMHSAPGNI...VEGPLTW.RALTSKSLPKSSAPTHDDDISlPEPIPYinvaaekDAIRAAPHVV
  205-  292 (127.76/72.51)	QMEENVLQLLSeRDDIFERAT..YRETLAL.DW.RAKRAAAAAValaVEQRMAEnSAEQGASVAAPEQPPAEPPLE.PEDIPV.......DEPGTLPHVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.06|      17|      31|     492|     522|       3
---------------------------------------------------------------------------
  492-  508 (30.80/41.12)	DSLGRLNDNCL..INLRTR
  524-  542 (27.26/ 7.36)	DAMGRLWTYILgvLSMETR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05164 with Med13 domain of Kingdom Metazoa
Unable to open file!