<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05147

Description Uncharacterized protein
SequenceMLPTVPEKCGPPTITLGLLVDFAVQQTYHELTVLAELLPKKLDADRKISIVQFAHSTRTLFIKLLAIVKWLKSSKKFDSCASICYFLDQQAQYFIDTADYLVTLAREELVHARLPAFQVPAAIDVLTLGDFPRLPVCITSQFVTDHSITKREETSVLYRLNQVLKTKLSQSSASLSHRIREITFKNGMVTLIVPGEFEISLTLLGQKPTTKWTLLNIRFLVEDYEIGFGTQLIHPLQVNSVHNLLQLRMDQSEEPLKEAYNILHSVAQSLQLDILFCQATQVISGHMRKYATIESYSREEGVLVIAYWLRWTQQKRYVSQYRIKIFIDRNDPHSGLRIRHYPPNKRLPGIDDRSGRLSMNKILSQTMSIRCHEKLLRVRSGLEKIKPLTRVILTGNATFTLTYPLLERNSHVSEKLVVSVNSFSGRLEAVVAALGDCKEVKELALLLNEDAFLEKVAAVIVRLRVLLMMERFRKAVAPLPVRIVDESVVYAQFSSLKIIGLDRLCFQFIKEDIYFLVVSFKGKNKGTIDLEIYLFSSIDGRTSRLQLHPSQMLETWTSANFRSDCEDPSATRQRWLGSTKQLTSAIAAIDDRLAFMRLCDELDKRKVKYLPLETEHVVGGLILRITDFSEAITTGSKDFFDLLVNCCLRLDTRARVIWPFEYTLSENPLTPDYYDSAERASTKAERTKTTVLEIFANGGLGQLSTSENLYLSMIERLIVFSHMYEIAKQFAKAYYLHFHRFCNISAFTYYKLVIAYGELRNNLMLLTWKVQKTPKPAQYFHLTFGMCSMRDVANGKNSFLPVKDLSWNPHTILQARLQDMFNRKRSLAELMQYLIETVEPLSCLYSFAHMRIQSLRTYAQIMGYETALPIALQTNLVAVNETTLRLSFGAVTLEFLLLGDSKIGIRDASRRAAAAFHLRSFCNKFSRHCQEMISTIHDGHSPGPNWLRSPSAPSSLPHHMSRSPAMRLTSSPISHVSLSVPPSELELSPMRSSENASLSRTPILIDHAALRRITTVDPTGFCPLYEYLYALAYLARLGPALENYQNEHRAGSLPAIQFGYLKHNGECVQFSVPCAVPTAVKHDFLNLNIYLDERTMSLKLELKYESDEVPSRGEIEVAERYFEKCVAPLGNELAVIAFANACRSTSMGTFTAMTQIMEAQMMWREDSPWKPALQLVTSSTDSMTQRMRVTPGIIIDPSNVNVLVLVCLRPSRVDFTERGSDTTKQLIALIYNTQTNTVARRSSADDDNDNASSLLSSVSDQYSRTAERTLWAAVRTLAYKYVQS
Length1284
PositionTail
OrganismEnterobius vermicularis (Human pinworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Oxyuridomorpha> Oxyuroidea> Oxyuridae> Enterobius.
Aromaticity0.09
Grand average of hydropathy-0.091
Instability index42.82
Isoelectric point8.83
Molecular weight145751.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05147
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.90|      18|      18|     446|     463|       2
---------------------------------------------------------------------------
  446-  463 (28.59/17.47)	LLNEDAFLEKVAAVIVRL
  466-  483 (30.31/18.95)	LLMMERFRKAVAPLPVRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.60|      30|     203|     403|     436|       3
---------------------------------------------------------------------------
  403-  436 (40.04/41.74)	YPLLErNSHVSEKLVVSVNSFSgrlEAVVAALGD
  609-  638 (51.57/36.91)	YLPLE.TEHVVGGLILRITDFS...EAITTGSKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     602.01|     200|     560|      77|     306|       4
---------------------------------------------------------------------------
   77-  306 (280.68/325.51)	FDSCASICYFLDQQAQyFIDTADYlvTLAREELVharlPAFqVPAA..............IDVLTLGDFPRLPvciTSQfvtDHSITKREETSVLYRLNQVLKtKLSQSSASLSHRIREI...TFkngMVTLIVPGEFEISLTLLG...QKPTTKWTLLNIRF.LVEDYEIGFGTQLIHP...LQVNSvHNLLQLRmdqseepLKEAYNILHSVAQSLQ........LDILFCQATQVISGhMRKYATIESYsreEGVLVIA
  640-  871 (321.33/261.18)	FDLLVNCCLRLDTRAR.VIWPFEY..TLSENPLT....PDY.YDSAerastkaertkttvLEIFANGGLGQLS...TSE...NLYLSMIERLIVFSHMYEIAK.QFAKAYYLHFHRFCNIsafTY...YKLVIAYGELRNNLMLLTwkvQKTPKPAQYFHLTFgMCSMRDVANGKNSFLPvkdLSWNP.HTILQAR.......LQDMFNRKRSLAELMQylietvepLSCLYSFAHMRIQS.LRTYAQIMGY...ETALPIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.36|      14|      18|     509|     523|       5
---------------------------------------------------------------------------
  509-  523 (19.70/17.92)	IKEDIYfLVVSFKGK
  528-  541 (24.66/16.18)	IDLEIY.LFSSIDGR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05147 with Med14 domain of Kingdom Metazoa
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