Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MSASGASSSGLKLNQRLKVISDVDQKITELVKHAQACILELSREKQISKTKMEEHSSAFKKCLNSIEADLSGQMQYLSHVCVGTAHQGTTFASQQRTMLAERSFDSLRDHLEAINNTHLSQTNDVQME |
Length | 128 |
Position | Head |
Organism | Enterobius vermicularis (Human pinworm) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Oxyuridomorpha> Oxyuroidea> Oxyuridae> Enterobius. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.491 |
Instability index | 35.93 |
Isoelectric point | 6.58 |
Molecular weight | 14207.88 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP05137 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) AERSFDSLR 2) ISKTKMEEHSSAFKKCLNSIE 3) MSASGASSSGLKLNQRLKVISDVDQKITELVKHAQACILEL | 100 47 1 | 108 67 41 |
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