<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05135

Description Uncharacterized protein
SequenceMTVCGEEICVIVGEVSETNLFGWELLISMGDGKNSKEEAEKGKVILCYGKREYVVSEERKEGSPDDNGERRQKNAVKKPRQFDLATMFEETHRVAAERNAERGLRSSFQDSLISPHEKEESTEISEVSDPADPLPLWLIKVLTEQKKKSEDDTKEEDDADVFTVPLPKNFVSAPSSSEQPDPSAVLDQGDTMSAEKEDDDDFEDFGEVPVMQLIPTECEVVVLNGKKPVSALAFDHQGTRFACGGWDYAVNLYEFQKMDYTFRPSRELAPCESHVINDLAFSTNGEQLLVASGHAQIRILDRQGKQWAETVRGDQYLVDLSNTSGHTSAVNCCCWHPLIKTEFLSCGDDGTLRIWSLDDYKELRHCITKQRKVIKTKTGGGRRAIATCCAYSRDGKLIGAGCSDGSIQIWKNGNLFVNTTYLNRTAHSKPVTSIQFSANGQQILSRSLDGTLKLFDLKSFKEPVLMKNDLFTDFEGTDCGFSPRGELVFTGTSTSDDGGIDGALLFFDSSNFELVYQIKYPKLSCMRIKWHEKINQILVALSDGSLRLYYDPVSSARGALLCVSRPLRRARQQEVVREEMILSPLTLEMFQPRGEEGEEKEVTTWRLRKFLRMQDNKLRPDFRKPADMPMSGPSSGGRQMGTKRNRDFLADTDVRASILRHAEEAEKNPYYVAKAYLKNQPVTIFQEKTTAPEEEEGDAELQPLYKQPMIDYHFKEELEKSREKVEDLFNFEGFKIGRGTYGHVYKAHPRRPDIFGEDTKKEYALKLIEGQGFSMSACREIALLRELKHPNLIRLRRVFLTLERKVWFCMDFAEHDLWHIIKFHRAAKQKKTPVLVPKGMVKSLLYQILDGIHYLHTNWILHRDLKPANILVTGEGPGVERGRVKIGDMGFARVFYNPLRPLAELDPVVVTFWYRAPELLLGAKHYTKAIDIWAIGCIFAELLTSEPVFFCREEDIKASSPYHQDQLNRIFTVMGFPSEKEWEDLKKMPEYQKLIQDFKRTSYANCTLQRYMEKHKIRAETPAFSLLQRLLTMDPIKRITAQEALDDDYFKEDPKPTADVFNGCAIPYPKREYLSDENEVKSGSGSKTQQAPPPQQSQQQPITMHQQQPIIEPAAKKMRLQSTQQMPPTQPQMEPPLINPSVSGIFASNVSNQDYPPVGSGSKAMQFEQQHQPPVIQSQQINNSNMQQLPYPQHQQHQIISQGPNMYQQQPQISMNQPMVPTSQPHISARPMQMPAQTNIMQSSYQQPIMQPSGMIVPQPAPEMMPQQGQYMMPQQQQWPPMQQRYQ
Length1287
PositionKinase
OrganismEnterobius vermicularis (Human pinworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Oxyuridomorpha> Oxyuroidea> Oxyuridae> Enterobius.
Aromaticity0.08
Grand average of hydropathy-0.608
Instability index52.35
Isoelectric point6.02
Molecular weight146705.19
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05135
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     180.06|      26|      99|    1086|    1111|       1
---------------------------------------------------------------------------
 1086- 1103 (28.54/10.43)	...................SKTQ.QAPPP....QQSQQQPIT
 1104- 1135 (32.99/13.20)	MHQQQ..PIIepaakkmrlQSTQ.QMPPT....Q.PQMEP..
 1167- 1201 (33.06/13.24)	FEQQHqpPVI..qsqqinnSNMQ.QLPYP....QHQQHQIIS
 1206- 1219 (23.27/ 7.15)	MYQQQ..PQI.........................SMNQPM.
 1220- 1250 (35.55/14.80)	VPTSQ..PHI........sARPM.QMPAQtnimQSSYQQPIM
 1251- 1272 (26.66/ 9.26)	QPSGM..IV..............pQPAPE....MMPQQGQYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.19|      25|      39|     584|     619|       2
---------------------------------------------------------------------------
  584-  611 (37.22/24.61)	PLTLEMfqpRGEEGEEKEVTTWRLRKFL
  625-  649 (43.97/32.44)	PADMPM...SGPSSGGRQMGTKRNRDFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.12|      15|      39|     902|     919|       3
---------------------------------------------------------------------------
  902-  919 (24.32/23.55)	LAEL...DPVvvtFWYRAPEL
  939-  956 (23.80/13.96)	FAELltsEPV...FFCREEDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.81|      36|      39|     697|     734|       4
---------------------------------------------------------------------------
  664-  696 (28.05/10.73)	.EAEKNPYYvakaylkN....QPVT..IFQEKTTAPEE..E.....E..
  697-  734 (59.85/35.96)	GDAELQPLY.......K....QPMIdyHFKEELEKSREKVEDLFNFEGF
  737-  773 (50.90/24.72)	GRGTYGHVY.......KahprRPDI...FGEDTKK..EYALKLIEGQGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.00|      25|      40|     815|     842|       5
---------------------------------------------------------------------------
  815-  842 (37.21/46.13)	HDLWhIIkfHRAAKQKKTPVL.....VPKGMVK
  856-  885 (39.79/32.49)	HTNW.IL..HRDLKPANILVTgegpgVERGRVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     286.27|      46|      46|     405|     450|       6
---------------------------------------------------------------------------
  249-  292 (41.71/25.60)	.AVNLY..........efqKMDYTFRPSR....EL....A.PCESH.VIND...LAFST.NGEQLL...VAS...
  295-  349 (45.00/28.28)	AQIRIL............dRQGKQWAETVrgdqYLvdlsNTSGHTS.AVNC...CCWHPlIKTEFL...SCGDD.
  350-  398 (34.38/19.63)	GTLRIWslddykelrhcitKQRKVIKTKT....GG....GRRA....IATC...CAYSR.DGKLI..........
  405-  450 (75.39/53.02)	GSIQIW.............KNGNLFVNTT....YL....NRTAHSK.PVTS...IQFSA.NGQQIL...SRSLDG
  462-  498 (48.64/31.24)	EPV.LM.............KN.DLF..TD....F.......EG......TD...CGFSP.RGELVFtgtSTSDDG
  502-  544 (41.15/25.14)	GAL....................LFFDSS....NF....ELVYQIKyPKLScmrIKWHE.KINQIL...VALSDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.12|      44|      46|     124|     167|       7
---------------------------------------------------------------------------
  124-  167 (74.45/45.67)	ISEVSDPADPLPLWLIKVLTEQKKKSEDDTKEEDDADVFTVPL.P
  171-  215 (71.67/43.68)	VSAPSSSEQPDPSAVLDQGDTMSAEKEDDDDFEDFGEVPVMQLiP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05135 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EYLSDENEVKSGSGSKTQQAPPPQQSQQQPITMHQQQPIIEPAAKKMRLQSTQQMPPTQPQMEPPLINPSVSGIFASNVSNQDYPPVGSGSKAMQFEQQHQPPVIQSQQINNSNMQQLPYPQHQQHQIISQGPNMYQQQPQISMNQPMVPTSQPHISARPMQMPAQTNIMQSSYQQPIMQPSGMIVPQPAPEMMPQQGQYMMPQQQQWPPMQQRYQ
2) QKKKSEDDTKEEDDADVFTVPLPKNFVSAPSSSEQPDPSAVLDQGDTMSAEKEDDDDFEDFGE
1072
145
1287
207










Molecular Recognition Features






MoRF SequenceStartStop




NANANA