<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05119

Description Uncharacterized protein
SequenceMSRKIYGDMEDEEEYMKPMLPTVPEKCGPPVISLGHLIEFAVQQIFHELTVLSEFIVQFAHSTRTLFIKLLAVVKWVKSSKKFESCASICYFLDQQSQYFIDTADRLVQLAREDLIHARVHDLLEKPIEHISICVRLDNLITYDEVGLQIFFLQSRFIRPSEITAREQASILARLNQVLQTRISICAKRMSPRITSVLIKNGMVTLTVPGEFSVSLSLLGERDTTKWTLLNIKILVEDYEIGYGTKLVHPLQVNMLHNVLQLRMDKADDAISEVYNFLHSFAQSLQLDVLYCQATQAVRGPMRQYTTIDRYDRTQGILIISYWLKKTHHNRFSSQYRIKISSSADNINSGLRVRHYPDGKNLPKIDDRTGRLSISGILSETVVIRCRERLLQIRECLKSLKPFSPVSLTGKAAPTLTYPLLGPESNQDEMLIISVNGFSGDVLVIVRALVLYSSRLELCELERFLNDRSSIQRISSLIYRLRILLMMERYRKSIASLAVRIVPEKTLSVLLPNISSLPSDRLCLQFVKEDAFFLIISWKSDDIKGFDIDMYLFCNTERKTNMIRLHPSQVLSSSPSSNFSSYDKSIGMPSVQRKRWIGNVKELSSAIAIIDDRIAFMRICEELSKRCVSYQPVTKEPVVGGLLLQISDFSGALPSASKEFFSSMTNCCLRLDTRSRVIWPFECTLTETPLIADIPGSANVLGKRSRTKLTVMEINGSGGISSLNTSESVSIHMLDRLTIFSHMYEPVREFADAYYSYYNQYCNIVAFTYHKLVIAYGTNRNYLVIISWKSQKTTKPYFYLTLGIWPNQRNLNNKCEQMNENVWNPHILMHQRLQEQFNRHRSLCQLMQYLIDTISPLCCLHNFIHMRLHSLRAYCQLSNLEPSLPITLQANLSVIDEHTIRLLYGNIHLEFLLVGGYRVGVRDCGRGGVSAHRLKTFCNKFVSPEMRSANDEPSAYLNWMHSSSSGPGSLPPHQITRSPASRIAASPMSYLSLSVPPADTVPSPLRHPQGDHLRCRSPILIDHGALQTMTAINDSDYLFSLSYLSRLGPALESYRRDNRGNSPLPAIHLKSLLTTPELIRISVSGAVPPSPRNESFLAVLNVYLDDDTMSLKLRIDFENSSPPSESDLRIFERYFKRYIARSGNEIAFIAFSNACRIVSPGIFSSIARIMEAQMDWSENSPWRPSLQLTMWNQEGSTSRARISPGIAIDQTNTNILIPLCLRPTKRKDGERNADASKYVIPLIYNTQTNMITRRNSEEDSSNASTILLSITEQYSHTTECPLWFAVNSLAYKFVPSNTTSSIQC
Length1304
PositionTail
OrganismDracunculus medinensis (Guinea worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Dracunculoidea> Dracunculidae> Dracunculus.
Aromaticity0.08
Grand average of hydropathy-0.144
Instability index50.21
Isoelectric point8.86
Molecular weight148286.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05119
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     348.66|     111|     140|     761|     898|       1
---------------------------------------------------------------------------
  761-  898 (172.40/168.76)	YCNI.VAFTyhkLVIAY..GTNRNYLVIISWKSQKTTKPYFyltlgIWPNQRNLNNK....CEQMNENVWNPHIL.MHQRLQEQFNRHRSlcQLMQYLIDTISPLCCLHNFI.HMRLHSLRayCQlsnlepsLPItlqanlsVIDeH
  904- 1023 (176.26/110.93)	YGNIhLEFL...LVGGYrvGVRDCGRGGVSAHRLKTFCNKF.....VSPEMRSANDEpsayLNWMHSSSSGPGSLpPHQITRSPASRIAA..SPMSYLSLSVPPADTVPSPLrHPQGDHLR..CR.......SPI.......LID.H
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.06|      62|     244|     302|     404|       2
---------------------------------------------------------------------------
  232-  282 (65.05/27.18)	IKILVEDYEIGYGTKLVH.PLQVNmlhnvlqlrMDKADD....................................AISEVYNFLHSFA
  338-  404 (98.62/135.73)	IKISSSADNINSGLRVRHyPDGKN.........LPKIDDRTGRLSISGILSEtvviRC.......RER.....LLQIRECLKSLKPFS
  610-  657 (37.39/ 8.80)	....................................IDDRIAFMRICEELSK....RCvsyqpvtKEPvvgglLLQISDFSGALPSAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.43|      17|     139|    1118|    1134|       3
---------------------------------------------------------------------------
 1118- 1134 (31.59/22.21)	ENSSPPSESDLRIFERY
 1258- 1274 (28.84/19.49)	EDSSNASTILLSITEQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.45|      40|     479|     186|     231|       9
---------------------------------------------------------------------------
  186-  231 (62.00/64.07)	CAKRMSPRitSVLIKNGMVTLT.......VPGefsvSLSLLGERDTTKWTLLN
  667-  713 (68.45/51.42)	CCLRLDTR..SRVIWPFECTLTetpliadIPG....SANVLGKRSRTKLTVME
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05119 with Med14 domain of Kingdom Metazoa
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