<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05112

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMGDDDWPSQRFRDHVINRLEPELARSRQNAPNLPVPGDARQVEEYVFQKCVSKDEYMRTIAKVINAINCNSKSSALQTSQFTQQTQQDYRPPPDPQPTHQQHQPVVERYQAPPLGQPPPMLQSLPVSSGVLSSGSNQLSFQQCTVAHPSVPQQSQFGLLNKPSSTISPTQPSPTHQIYSRMSKQEPNIPATNIAQRGAIMNRMWKPAHEPLGGYVPPTTYGNVPPTSGSYMERPSTSYPSCAALAASPQSSSQLQQQSGILENLISPSHYGPQPPPTTHTLVNNIVMNNSMIMDPQQSISNVPNSQQNEQLQYMEKLRMLEHYTEPLRCRAQKHRIEGQEAIANKFDQICNVLQGRTRVSLDYLKQIETWIYKKSDLVLQQVPLSGAAATSVSQSQPQPLVDAMNAVLLNGESQSNCREQLQRGNNMTSTAEQWQNIGGQQASPHGPSVVLPIGLTAVQSGSIAQIHSPHQMQPPIQTRLDHASYQHSRHSPYPPASTVRSNSQLHQQISAHHISPKIAPPPVICDVPPPIIENVHSSGGMDGGNVEDLYVMDDFLPITFETLPSGTMMQVENQLPEAARRELHSLSDRFIVDPNIQPLSDSHSIIVKCSLRSYSVPPLLLVIPSTYPVGNVSVDRPALDIGLFFFFYSSESTVRSYYINQQQLQNTSSSAVLDDYSSFCNFDDIIT
Length687
PositionTail
OrganismDracunculus medinensis (Guinea worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Dracunculoidea> Dracunculidae> Dracunculus.
Aromaticity0.06
Grand average of hydropathy-0.534
Instability index71.11
Isoelectric point6.11
Molecular weight76117.55
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05112
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     398.92|      72|     174|      69|     140|       1
---------------------------------------------------------------------------
    7-   75 (44.20/12.16)	...............................PS....QR..................FRDHVINRLE.P...ELAR..SRQNAPNLPV..PGD..ARQVE.EYVFqkcvskdeymrtiakvinainCN.SKSSA
   76-  150 (121.41/45.54)	LQ.TSQFTQQT........QQDYR.PPPDPQPT....HQ..................QHQPVVERYQAP...PLGQ..PPPMLQSLPV..SSGVLSSGSN.QLSF...................qqCTvAHPSV
  151-  247 (91.08/32.43)	PQ.QSQFGLLN........KPSSTiSPTQPSPT....HQiysrmskqepnipatniaQRGAIMNRMWKPahePLGGyvPPTTYGNVPP..TSGSYMERPS.T.SY...................psCA.ALAAS
  248-  313 (70.46/23.51)	PQsSSQLQQQSgilenlisPSHYG.PQP.PPTT....HT..................LVNNIV...MNN...SMIM..DPQ..QSI.....SNVPNSQQNeQLQY.............................
  475-  539 (71.77/24.08)	PI.QTRLDHAS........YQHSRhSPYPPASTvrsnSQ..................LHQQISAHHISP...KIA...PPPVICDVPPpiIENVHSSG....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.31|      16|      19|     437|     452|       2
---------------------------------------------------------------------------
  437-  452 (30.89/17.36)	IG......GQQASPHGPSVVLP
  453-  474 (25.43/12.87)	IGltavqsGSIAQIHSPHQMQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05112 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ESQSNCREQLQRGNNMTSTAEQWQNIGGQQAS
2) MGDDDWPSQRFRDHVINRLEPELARSRQNAPNLPVPGDA
3) PLGGYVPPTTYGNVPPTSGSYMERPSTSYPSCAALAASPQSSSQLQQQSGILENLISPSHYGPQPPPTTHTLVNNIVM
4) PQQSQFGLLNKPSSTISPTQPSPTHQIYSRMSKQEPNIPATNIAQRGAIMNRMWKPAH
5) SALQTSQFTQQTQQDYRPPPDPQPTHQQHQPVVERYQAPPLGQPPPMLQSLPVSS
6) SIAQIHSPHQMQPPIQTRLDHASYQHSRHSPYPPASTVRSNSQLHQQISAHH
412
1
210
151
74
462
443
39
287
208
128
513










Molecular Recognition Features






MoRF SequenceStartStop




NANANA