<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05109

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMGDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDARQVEEYVFNKCVSKDEYMRTIAKVINAINCNSKPSAVPSLLQPSRIQSASQNYRGAGLGIPPDPQPTHQQHQQKVMDRYHTSLCQTPPMMQSQESPSGALSGGNMQLSQSSLQQHSPVTHPVVPQVPYNMLSPIPSVPGSQNTSPNHQMYSRVKTEPKSSGNDGGAAEIPISDAMSARVWKREVPPPGNYYSAGFYDATSSNQYVERTHSSAPFMPRGTPISPSQQLTASPHHHHQHHQQHQPSVLENLINSPHYGSPMQSSQHVNGSGNQSVADLPFGNAIQQNDERMYTEKLRSLRPYVESLRARAQQCRLEGNEIAASKFDTMCNVLDGKSRVSFEYLLQIEAWIYKKQQFLVSNIVLNVCMLRIDLTTKYVSSSILQRKQASLNTGTLQPQPLVDAVNAVLLINSEAQVGYGDRVQTNTGVPSAGQWSVQSSRPQQQTSSQGLPNMVPSSVPVAHCPVRSTLMQSSIPLQTTSGQQVARHSIEHTYQRHSPYPNPNAGLRSGTQSVVLHHGLSRVQPAATVAALPPFSEANRTPATTDCSRVEDLYVMDDFLPTPIEAVSNNTSSQMEGLLPEAVRQELLAFGDRILADSNIEQMTDSHSVIVKFSLTSHNVPPLQLIIPKAYPNGEVMVGRAALDLDSFFFDDLQNVIHERLARPGLRTVTDFLETWVSFSSLKL
Length719
PositionTail
OrganismBrugia pahangi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.06
Grand average of hydropathy-0.516
Instability index61.97
Isoelectric point6.82
Molecular weight79407.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05109
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.73|      19|      21|     259|     279|       1
---------------------------------------------------------------------------
   87-  112 (30.54/ 9.53)	SASQNyrgaglgIPPDPQPTHQQHQQ
  261-  279 (39.19/21.15)	SPSQQ.......LTASPHHHHQHHQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.52|      27|     169|     122|     153|       2
---------------------------------------------------------------------------
  122-  148 (49.89/21.09)	LCQTPPMMQS..QESPSGALSGGNMQL.SQ
  162-  191 (37.67/18.03)	VPQVPYNMLSpiPSVPGSQNTSPNHQMySR
  193-  210 (22.96/ 6.16)	..KTEP........KSSGN.DGGAAEI.PI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.98|      21|      21|     459|     479|       3
---------------------------------------------------------------------------
  459-  479 (41.62/20.11)	QTNT.GVPSAGQWSV............QSSRPQQ
  480-  513 (26.36/10.21)	QTSSqGLPNMVPSSVpvahcpvrstlmQSSIPLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.88|      33|      58|     228|     260|       4
---------------------------------------------------------------------------
  228-  260 (59.61/33.29)	NYYSAGFYDA.TSSNQYVERT.HSSAPFMPRGTPI
  287-  321 (46.27/24.27)	NLINSPHYGSpMQSSQHVNGSgNQSVADLPFGNAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.85|      25|     170|     427|     458|       7
---------------------------------------------------------------------------
  427-  458 (37.45/34.66)	NTGTLQPQPLVDAVNAVLLinseaqvGYGDRV
  605-  629 (43.40/25.33)	NTSSQMEGLLPEAVRQELL.......AFGDRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05109 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVPSLLQPSRIQSASQNYRGAGLGIPPDPQPTHQQHQQKVMDRYHTSLCQTPPMMQSQESPSGALSGGNMQLSQSSLQQHSPVTHPVVPQVPYNMLSPIPSVPGSQNTSPNHQMYSRVKTEPKSSGNDGGAAEIPISDAMSARVWKRE
2) MGDDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDA
3) QSSIPLQTTSGQQVARHSIEHTYQRHSPYPNPNAGLRSGTQSVVLHH
4) SNQYVERTHSSAPFMPRGTPISPSQQLTASPHHHHQHHQQHQPSVLENLINSPHYGSPMQSSQHVNGSGN
75
1
507
240
222
39
553
309










Molecular Recognition Features






MoRF SequenceStartStop




1) YYSAGFY
229
235