<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05104

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKNRKGIQFIKGICFVFFLQTELNGLKWKCLTTPLSQRTWTSLEQDPVLSAYARCLQAGILCAWRRQPPQPTGTLAAMQLPDYRIDVVKELWVFWYSHEEPDCLTEYTSHLACSEDGQGNWSVPGIQYETRTLFFKALHNLIERNMLKNGYIRIGKYFTRPYEVPSSDRIHCSPSYVNGISFNFFVHGENIVCATVSVQRQPTLFRLSRRHLDLGKKQPVILGPWSMRAVLLPEQPRIVDSTTPSLQQQSSAPQYGNFTSLSSVAHQVNPVPSSSIDSDTISNSYDGAGTISKAAVDKLWSEWLQFFCLIVNVERNLGSADTVGYIGYTENTSPAKNSLPKMVLVDVDGVHMWYPSSLIVVQASDDLLLRQNEKTINDEDSDFFNSGSNSSSFTARTPPATGGHARLRSTPSFRKRKKRLSECDTGSNAERHNAMYGTMVNGARAAQRFFEESFIAPASSRRKESTESPSSSGLGLLMSAATNDDDCRWNFTDGMRRKDREEGCGCHHCRLQQSSSATALPSLPSQCITLQQGIIYYNHLSYPFVYFFISFLQYDTCIDQESNQSCCTPVNFSNSSLETKKEGSAIFHRRSSSCTRSPSPPRSPPWEKKILATSSETGDSEHNLDWIRESYFRNSRSSSRSGRADLLHEDRHICPKTPDASTIMESPERRRVQRNSVQMFGKIGSCKPIYQNLSPTSRPRSPACDTSQAESLGRMQSKDCLSNDFASSAGKHTPTITDQQPNLINSLRLKKGKKLKGRKRKADEKLEWSGIESLDVSFLTAKVGEDNEDDDNINFTCPSNFKLRECKSVINGEVVESSNAVPHTRSSLNVSTSQSQDVLRSLPVFSQIGSAMPSNAGVNLTPSIFTSDCDTQPLFLDDCNPSAITMVERKSPVDTVVTDSVHLSPPASNERVEPTQILGGTVANVMARVGGPPSVGDYMIYPTPPSVDATQSQQFSPQNTLIQANPTSILYPPTVSYMAAAAAAAVNLCHNIPPVQLPPTVVSETDATTEATPTIKRELENDDERHLGKLHYSIGEKPVYGKFMQLEMALSRKFAGNILAKEFLSLEAKECRMLEGVYADQLKLIKAAVAAREKRKKVGRAPDYLFMRERLRNLAPHSSFTTVRHYRIPYNNGHMFSSHCLPTLQMLPHGMSMNGVPNFVTNGPPFGAASYNGNNSVMSMMMSSGCLPPGGTTIMQPVPSSSRMGVVHMNQQMSMAHLRPLARIPSMPPYASSQTGPLQHPPFMGQSAQFCSPPGVMNAPNPISSFPGGPMCSMSTGPVQSSHMLSGMHGTTPSQPLGANNMHAAGPPNGQFSMQQPQQPFQQLSHFVNNANFNGQVGMTAVNPSQQSIYQQQIMFRCNMNGNLPAQHPIHSSDSYGIDSQGQAPVEPPPPFSQSINQQYAAVHNVQGGSMIYPQSAHMMRQNTLMSQAQNQNMMCGPRTSQNPMMTVPSSIGSPNNGGLFGNRLMNMPHVMDTAAVPPNNIRTHPEGKSLVLAVLLQDTVLDLHYDSVFDACPICSCNGSIRAKELGVYITPPEVLRQPPAQQQLIVSKPTSGFYNSTSNSCNCGFSAVRHRYLSMKAGLFAEDAKEATDINETQSQPAIPHTIWFDSMSGRDMNFIALLREQTLVRDLGGLLDQVTLLSLQCERASQTERIGSDSSKHCEYIISEVDQRELPLVFQAACEVACMEMNCRRPPHDVRSVLLHDWGVQISNEMREPRESECMALLQEIGPILEESLRIARSSPLFGSNNIVEGPLTWRFFDRKALKAAGGTEDDSGPEAVPNIVVASEKDAVITSPQIIRLWEKMSLEPYDQPKDVLYIGVVPDNLICIEKTKKYLMDLSRMYEQCRFGRHIPFSREVLRDGLLRVPTRYPATNPGECDNFLNQVERHIGDNKSLITRLKVYMQYFENEMARILINNDDIFSRDKYRAALAESQIHSVQHISIAAYQCGVSSSDHMPPPSAPGSIIISGQSGDASHGPNSTSGPSSSGVTIGESLTPDGSIGDGSAQNMTNFSSFMTEQLVADGIIAEDEPGTLPHVIVIYLVNPFLLGAEENPLVARVVTVALMRAFNALLYRLNNKRRPQLQLEMIALQNIFDYCGASADFLKDERGRLNGYDQGRLEKSQNERLSSSDSLKTIAFSVYTHSRVVLPDIVRGILPKSMTRFGPASAMVDLLNELERKEPIYYKVPSKPFILAPPSPVMQRPNCDLMQINTDEAVLFVSYCLIGNDWLAATVTDHQGHSLDNCLINLRLKPDHKRVNMRYKQSTQIRDSLYRLWSYILGTLANGTRNWRLVIGRVGRIGHGEFKFWTQILSKSYLKQVGTRMKHVCRACHVMPGTSEVPGVLSACLVSLEPEAHLRVFPSSFQHDDRFLKNSRHRALTTPDDTSCTHILVFPTSPELNLDHQGGNGVAELEEDDFSNLLTEEIGEEFSELIGNGEDLMTNGTGPPPQSASFRLGGNTGIPSEYADVSIENQPLATGYYISTAPASDLPEWFWSACPSAKRRNPVHLKSSLHLNTPNVQQGDDISSFGKGTEACHHQLDSQATADVLRYVLEMYNALSWLNMDLVSGERRSCLPIHIQALMWLCNAVNRFIN
Length2592
PositionMiddle
OrganismBrugia pahangi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.07
Grand average of hydropathy-0.384
Instability index57.45
Isoelectric point6.61
Molecular weight287109.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05104
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.49|      17|      50|    1543|    1560|       1
---------------------------------------------------------------------------
  958-  974 (32.11/18.41)	QNTLIQANPTSILYPPT
 1543- 1559 (31.38/23.80)	QQQLIVSKPTSGFYNST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.76|      35|      39|    1220|    1254|       2
---------------------------------------------------------------------------
 1220- 1252 (57.37/24.96)	.........................PLARIPSMPPYA..SSQTG.....PLQHPPFM.GQSAQFCS
 1253- 1294 (47.66/19.40)	PP................gvmnapnPISSFPG.GPMC..SMSTG.....PVQSSHMLsGMHGTTPS
 1295- 1359 (32.73/10.85)	QPlgannmhaagppngqfsmqqpqqPFQQLSHFVNNAnfNGQVGmtavnPSQQSIYQ.QQIMFRCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     376.11|     119|     169|       9|     146|       3
---------------------------------------------------------------------------
    9-  146 (193.64/161.16)	FIKGICFVFFLQTElNGLkwkCLTTP.........LSQRTWTSLEQDPVlsayarclqagILCAWRRQ....PPQP...TGTLAAMQ....LPDYriDVVKEL.WVFWYSHEEPDCLTEyTSHLACSEDGQGNWSVPGIQ..YETRTLFFKALHNlIERNM
  176-  317 (182.46/109.50)	YVNGISFNFFVHGE.NIV...CATVSvqrqptlfrLSRRHLDLGKKQPV...........ILGPWSMRavllPEQPrivDSTTPSLQqqssAPQY..GNFTSLsSVAHQVNPVPSSSID.SDTISNSYDGAGTISKAAVDklWSEWLQFFCLIVN.VERNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     370.84|     123|     534|     810|     947|       4
---------------------------------------------------------------------------
  649-  787 (174.48/118.90)	EDRHICPKTPdASTIMESPERRRVQRnSVQMFGKIGSCKPIYQ..NLSPTsrPRSPACDTsQAESLgrmqsKDClsNDFA.SSAGKHTP...TITDQ...QPNLINSlRLKKGKKLKGrkRKADEKLEWSGIESLDvSFLTAKVGEDN
  816-  947 (196.36/158.97)	ESSNAVPHTR.SSLNVSTSQSQDVLR.SLPVFSQIGSAMPSNAgvNLTPS..IFTSDCDT.QPLFL.....DDC..NPSAiTMVERKSPvdtVVTDSvhlSPPASNE.RVEPTQILGG..TVANVMARVGGPPSVG.DYMIYPTPPSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.57|      29|    1389|     594|     622|       5
---------------------------------------------------------------------------
  594-  622 (53.57/27.73)	CTRSPSPPRSPPWEKKILATSSETGDSEH
 1948- 1976 (51.06/26.03)	CGVSSSDHMPPPSAPGSIIISGQSGDASH
 1981- 2003 (26.93/ 9.61)	.TSGPSSSGVTIGES..LTPDGSIGD...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      18|    1389|    1018|    1037|       6
---------------------------------------------------------------------------
 1018- 1037 (28.77/24.68)	ELENDDERHLgkLHYSIGEK
 2410- 2427 (31.59/19.66)	ELEEDDFSNL..LTEEIGEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.82|      39|     166|    1393|    1440|       7
---------------------------------------------------------------------------
 1380- 1426 (54.83/51.96)	SQGQAP.VEPPPPFSQsiNQQYAAVHNVqgGSmiyPQSAHMMrQNTLM
 1427- 1466 (69.98/42.92)	SQAQNQnMMCGPRTSQ..NPMMTVPSSI..GS...PNNGGLF.GNRLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.04|      15|     534|    1062|    1170|      10
---------------------------------------------------------------------------
 1135- 1154 (28.41/115.04)	MFSSHCLPtlqmlPHGMS.MN
 1181- 1196 (28.63/30.34)	MMSSGCLP.....PGGTTiMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.05|      29|     813|    1103|    1131|      17
---------------------------------------------------------------------------
 1103- 1131 (53.73/37.03)	DYLFMRERLRNLAPHSSFTTVRHYRI.PYN
 1918- 1947 (45.32/29.95)	DDIFSRDKYRAALAESQIHSVQHISIaAYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      23|    1645|     535|     557|      20
---------------------------------------------------------------------------
  535-  557 (46.83/36.38)	IYYNHLSYPFVYFFIS.FLQYDTC
 2182- 2205 (41.72/31.29)	IYYKVPSKPFILAPPSpVMQRPNC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05104 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSNSSSFTARTPPATGGHARLRSTPSFRKRKKRLSECDTGSN
2) MMRQNTLMSQAQNQNMMCGPRTSQNPMMTVPSSIGS
3) NDFASSAGKHTPTITDQQPNLINSLRLKKGKKLK
4) NGNLPAQHPIHSSDSYGIDSQGQAPVEPPPPFSQSINQQY
5) PGVMNAPNPISSFPGGPMCSMSTGPVQSSHMLSGMHGTTPSQPLGANNMHAAGPPNGQFSMQQPQQPFQQLSHFVN
6) PSAPGSIIISGQSGDASHGPNSTSGPSSSGVTIGESLTPDGS
7) SSRSGRADLLHEDRHICPKTPDASTIMESPERRRVQRNSVQ
8) TVVTDSVHLSPPASNERVEPTQILGGTVAN
387
1419
723
1361
1254
1959
638
895
428
1454
756
1400
1329
2000
678
924










Molecular Recognition Features






MoRF SequenceStartStop




NANANA