<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05091

Description Uncharacterized protein
SequenceMGTTTEAIAASATSLTAAVGNDAEKLQWIVLNQVEGVQMREMFWDLSKDVDVDVLACSEAVKMLRTMTEEEKTQCCKASLSLLSNKDDPRYIHYERILSSIFMIACNEGVLPLSDCCELLILCTNFSLTTPMDSRKFEYMQKNLHLIDYKGLRNILKLLVVERMQEVPSTITHHHRHMLLPVENMLLTLIDRQLNLLPCIFTITELHRVSNNSRAFLLPRVAKKFNDMFISFRPLTEMVTIIGRSWLYPIAAHISFPMSTPSWKLEVTTTRLHQRAHLPYKSELFAPQSFLLYTLLRQPRGKDTISYVMRQNTSLTPQRLQCDELLHMIILEAMSEMEKTDTRLDDPANQYQWMNITQTVTFSLLHGNASFARLLKILYESLSETVYRKGRDELMWVILQYVAVYIDRVSNEEMVRVAEIYNLLYSDEQTWSGADTDPLLFVRFLVPAAIWIHFYKKLGNSHTEILPKPSESLWRQIQFLQERTADSDPNIQNVADHNAVLAAVANAYSSDMPNFQKLVLTAVDVFLDGSPEEMNTVWHLPYGIVSYSKKTPLPLSLIDSLTFHARNHLFQLCLLKLTAMLSIQQAQKVPSPATIDTLVRLAVTTEFEYGVKQVLALLSSTLASVNKSTNLGPAQQDRSRDLLFVLCDILSYRFISYPFPVGSKINLMLWCYTALGNSQVQMNIVLCSALEQVMMRYWMWNSPQEMFYLSNAFLGMSLYYFIVIEATPLRNFTLKIVNLGKQGKLAVIFNTANPAFCDPQHGNVSVEQQYTNSHISLELLRCLLLSMFRSLKMTGIYNIFILLSTISSLEVLSKINSQLIGCNVDDGAADTVIYDELMHRVIQEVHQVQEIIYAQGLAAEEQLLKFFSGERRQTIFCVVYNMLFETKKIHPVIYSVLNSMNNKELTATINKFTDYFIFIFKKNLPSDDQQFTAMIGILNDMAFNLHLISLDRLLISLVLHPTDDGATEIAMLIIHSLVGSYPDLHNRITALVHIIPSNKIGNSGAAFFNKMSEYYSQFPELSYREMEAKMRREMQIELGMRPIEQSTVNPELHMPIYYGNIMERILPIVDIILLRAIETVVADQLFTTLLMCFKPCYRYHPQPAAYMYSVLYCLDKTISHTVRARDFVLEICGQLEDRDGKYALLTPSFISDNHQLSLPSQFCQALVDRILQASNYAHQPPAFVYKDWRFAEMPPAGQALTGACIELLASPHAPVITAHALIDLVFIRPLHQPYATINAVALILTALPVSFQQVFYDHIVSVLDSEALHGDPSVCFGSLESECLLLTENQLLTNLALGHAYLQHCNTSSLAALPEFVRDQLAPKLVTEAQLIFVLRLVVPILQRFYDAKERSKQIQDLAVDVYKMTVKVNERVGVLKYEDSICDFLYHMKYMYVGDFVKNEAEQAIQRLSPSMRNKLKYISHTQMNTAIDLPHKLAPGPSNLDVVRRDVWMERSAASHTVQFSQTMKLIRGSSWYWGNMSWKDAEKVLMSQLPGTYLVRDSASDRYIFTISYRTKHSVHHTRLAQHGGNFCLGGPNSLVKANSLVSFIENSLQSCCKRRICMLMHPKSDSTGIETLELNHLLRRHELLPSLKYLCRVVIRNCVEKELLASLPLPSNMICYLEDPKYFVPPCLYHILHLSDSSYEGMLEAYAVLRHLRRYSTIFAMSSGALPAAISVIRVSGKESRRCLEELTGREKILPRELFYANIRRDGELIDRGMAVFLPGPKTSTGEDVAEFYVHGSRAVVDCLLEALAQFDNVQPAKAGEFTKRAFFNGKMTLHEVQSLAYLLAARTQRQRRLALHRNTLGKKQIIEVRASVEASIDFGDDVEFQWEDIRVAMSSIISELSCIQEQMKRGALINEGLRIVILGQTNVGKSSLFNHMANRDMAIVSSIEGTTRDSLEVTVQLSSVPVTIIDTAGIREIPLDSLEAEGIQRTLRRAVEADIIIVVLDSSMCKDFERDVRSVLSWCNLKKDTPVFVALNKCDLRSVPNNILLPWPTISISCISGEGISSLLKIISDYIDELCPISDNSALVSSQVHRLLVKEAISVLAKALKAKDVAIAAELLRDVSDCISEMSGIVVNEQILDEIFSSFCIGK
Length2096
PositionTail
OrganismBrugia pahangi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.08
Grand average of hydropathy0.044
Instability index46.56
Isoelectric point6.27
Molecular weight237628.99
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GTP binding	GO:0005525	IEA:UniProtKB-KW
GTPase activity	GO:0003924	IEA:InterPro

GO - Biological Process
intracellular signal transduction	GO:0035556	IEA:InterPro
negative regulation of signal transduction	GO:0009968	IEA:UniProtKB-KW
regulation of growth	GO:0040008	IEA:UniProtKB-KW
tRNA modification	GO:0006400	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05091
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.01|      15|      51|    2012|    2026|       1
---------------------------------------------------------------------------
 2012- 2026 (27.69/16.43)	LLKIISDYIDELCPI
 2064- 2078 (27.32/16.11)	LLRDVSDCISEMSGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     117.84|      24|      54|    1159|    1182|       3
---------------------------------------------------------------------------
 1132- 1148 (21.13/ 9.87)	....CGQLEDR...DGKYALLTPS
 1159- 1182 (43.43/29.16)	PSQFCQALVDRILQASNYAHQPPA
 1193- 1214 (29.91/17.47)	MPPAGQALTGACIELLASPHAP..
 1218- 1235 (23.38/11.81)	....AHALIDLVFIRP..LHQPYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.62|      21|      50|    1704|    1727|       4
---------------------------------------------------------------------------
 1704- 1727 (33.40/31.78)	YANIR..RDGELIDRGmavFLPGPKT
 1755- 1777 (33.21/22.08)	FDNVQpaKAGEFTKRA...FFNGKMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.47|      27|     686|     198|     230|       7
---------------------------------------------------------------------------
  198-  230 (39.62/39.03)	PCIFTIteLHRVSNNSraflLPRVAKKFNDMFI
  891-  917 (47.84/29.24)	PVIYSV..LNSMNNKE....LTATINKFTDYFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.29|      35|      53|    1024|    1058|       9
---------------------------------------------------------------------------
 1012- 1054 (54.81/40.77)	SEYY........sqfpelsyREMEAKMRREMQIELGM..RPIEQSTVNPELHM
 1055- 1107 (48.47/35.03)	PIYYgnimerilpivdiillRAIETVVADQLFTTLLMcfKPCYRYHPQPAAYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.10|      40|      54|    1796|    1841|      11
---------------------------------------------------------------------------
 1796- 1841 (52.85/66.97)	RRLALHRNTLgkKQIIEVRASVEASIDFGddvEFQWEDIRVaMSSI
 1853- 1892 (66.25/55.36)	KRGALINEGL..RIVILGQTNVGKSSLFN...HMANRDMAI.VSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.00|      34|      38|     549|     582|      12
---------------------------------------------------------------------------
  549-  582 (58.99/36.49)	KKTPLPLSLIDSLTFHARNHLFQLCLLKLTAMLS
  587-  619 (50.70/30.30)	QKVPSP.ATIDTLVRLAVTTEFEYGVKQVLALLS
  627-  647 (27.31/12.83)	KSTNLGPAQQD....RSRDLLFVLC.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.55|      20|      38|    1285|    1304|      13
---------------------------------------------------------------------------
 1285- 1304 (34.66/23.18)	LLTENQLLTNLALGHAYLQH
 1325- 1344 (32.89/21.58)	LVTEAQLIFVLRLVVPILQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.43|      18|      44|      74|      91|      16
---------------------------------------------------------------------------
   74-   91 (32.94/17.23)	QCCK.....ASLSLLSNKDDPRY
  115-  137 (28.49/13.98)	DCCEllilcTNFSLTTPMDSRKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05091 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA