<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05091

Description Uncharacterized protein
SequenceMGTTTEAIAASATSLTAAVGNDAEKLQWIVLNQVEGVQMREMFWDLSKDVDVDVLACSEAVKMLRTMTEEEKTQCCKASLSLLSNKDDPRYIHYERILSSIFMIACNEGVLPLSDCCELLILCTNFSLTTPMDSRKFEYMQKNLHLIDYKGLRNILKLLVVERMQEVPSTITHHHRHMLLPVENMLLTLIDRQLNLLPCIFTITELHRVSNNSRAFLLPRVAKKFNDMFISFRPLTEMVTIIGRSWLYPIAAHISFPMSTPSWKLEVTTTRLHQRAHLPYKSELFAPQSFLLYTLLRQPRGKDTISYVMRQNTSLTPQRLQCDELLHMIILEAMSEMEKTDTRLDDPANQYQWMNITQTVTFSLLHGNASFARLLKILYESLSETVYRKGRDELMWVILQYVAVYIDRVSNEEMVRVAEIYNLLYSDEQTWSGADTDPLLFVRFLVPAAIWIHFYKKLGNSHTEILPKPSESLWRQIQFLQERTADSDPNIQNVADHNAVLAAVANAYSSDMPNFQKLVLTAVDVFLDGSPEEMNTVWHLPYGIVSYSKKTPLPLSLIDSLTFHARNHLFQLCLLKLTAMLSIQQAQKVPSPATIDTLVRLAVTTEFEYGVKQVLALLSSTLASVNKSTNLGPAQQDRSRDLLFVLCDILSYRFISYPFPVGSKINLMLWCYTALGNSQVQMNIVLCSALEQVMMRYWMWNSPQEMFYLSNAFLGMSLYYFIVIEATPLRNFTLKIVNLGKQGKLAVIFNTANPAFCDPQHGNVSVEQQYTNSHISLELLRCLLLSMFRSLKMTGIYNIFILLSTISSLEVLSKINSQLIGCNVDDGAADTVIYDELMHRVIQEVHQVQEIIYAQGLAAEEQLLKFFSGERRQTIFCVVYNMLFETKKIHPVIYSVLNSMNNKELTATINKFTDYFIFIFKKNLPSDDQQFTAMIGILNDMAFNLHLISLDRLLISLVLHPTDDGATEIAMLIIHSLVGSYPDLHNRITALVHIIPSNKIGNSGAAFFNKMSEYYSQFPELSYREMEAKMRREMQIELGMRPIEQSTVNPELHMPIYYGNIMERILPIVDIILLRAIETVVADQLFTTLLMCFKPCYRYHPQPAAYMYSVLYCLDKTISHTVRARDFVLEICGQLEDRDGKYALLTPSFISDNHQLSLPSQFCQALVDRILQASNYAHQPPAFVYKDWRFAEMPPAGQALTGACIELLASPHAPVITAHALIDLVFIRPLHQPYATINAVALILTALPVSFQQVFYDHIVSVLDSEALHGDPSVCFGSLESECLLLTENQLLTNLALGHAYLQHCNTSSLAALPEFVRDQLAPKLVTEAQLIFVLRLVVPILQRFYDAKERSKQIQDLAVDVYKMTVKVNERVGVLKYEDSICDFLYHMKYMYVGDFVKNEAEQAIQRLSPSMRNKLKYISHTQMNTAIDLPHKLAPGPSNLDVVRRDVWMERSAASHTVQFSQTMKLIRGSSWYWGNMSWKDAEKVLMSQLPGTYLVRDSASDRYIFTISYRTKHSVHHTRLAQHGGNFCLGGPNSLVKANSLVSFIENSLQSCCKRRICMLMHPKSDSTGIETLELNHLLRRHELLPSLKYLCRVVIRNCVEKELLASLPLPSNMICYLEDPKYFVPPCLYHILHLSDSSYEGMLEAYAVLRHLRRYSTIFAMSSGALPAAISVIRVSGKESRRCLEELTGREKILPRELFYANIRRDGELIDRGMAVFLPGPKTSTGEDVAEFYVHGSRAVVDCLLEALAQFDNVQPAKAGEFTKRAFFNGKMTLHEVQSLAYLLAARTQRQRRLALHRNTLGKKQIIEVRASVEASIDFGDDVEFQWEDIRVAMSSIISELSCIQEQMKRGALINEGLRIVILGQTNVGKSSLFNHMANRDMAIVSSIEGTTRDSLEVTVQLSSVPVTIIDTAGIREIPLDSLEAEGIQRTLRRAVEADIIIVVLDSSMCKDFERDVRSVLSWCNLKKDTPVFVALNKCDLRSVPNNILLPWPTISISCISGEGISSLLKIISDYIDELCPISDNSALVSSQVHRLLVKEAISVLAKALKAKDVAIAAELLRDVSDCISEMSGIVVNEQILDEIFSSFCIGK
Length2096
PositionTail
OrganismBrugia pahangi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.08
Grand average of hydropathy0.044
Instability index46.56
Isoelectric point6.27
Molecular weight237628.99
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GTP binding	GO:0005525	IEA:UniProtKB-KW
GTPase activity	GO:0003924	IEA:InterPro

GO - Biological Process
intracellular signal transduction	GO:0035556	IEA:InterPro
negative regulation of signal transduction	GO:0009968	IEA:UniProtKB-KW
regulation of growth	GO:0040008	IEA:UniProtKB-KW
tRNA modification	GO:0006400	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05091
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.01|      15|      51|    2012|    2026|       1
---------------------------------------------------------------------------
 2012- 2026 (27.69/16.43)	LLKIISDYIDELCPI
 2064- 2078 (27.32/16.11)	LLRDVSDCISEMSGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     117.84|      24|      54|    1159|    1182|       3
---------------------------------------------------------------------------
 1132- 1148 (21.13/ 9.87)	....CGQLEDR...DGKYALLTPS
 1159- 1182 (43.43/29.16)	PSQFCQALVDRILQASNYAHQPPA
 1193- 1214 (29.91/17.47)	MPPAGQALTGACIELLASPHAP..
 1218- 1235 (23.38/11.81)	....AHALIDLVFIRP..LHQPYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.62|      21|      50|    1704|    1727|       4
---------------------------------------------------------------------------
 1704- 1727 (33.40/31.78)	YANIR..RDGELIDRGmavFLPGPKT
 1755- 1777 (33.21/22.08)	FDNVQpaKAGEFTKRA...FFNGKMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.47|      27|     686|     198|     230|       7
---------------------------------------------------------------------------
  198-  230 (39.62/39.03)	PCIFTIteLHRVSNNSraflLPRVAKKFNDMFI
  891-  917 (47.84/29.24)	PVIYSV..LNSMNNKE....LTATINKFTDYFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.29|      35|      53|    1024|    1058|       9
---------------------------------------------------------------------------
 1012- 1054 (54.81/40.77)	SEYY........sqfpelsyREMEAKMRREMQIELGM..RPIEQSTVNPELHM
 1055- 1107 (48.47/35.03)	PIYYgnimerilpivdiillRAIETVVADQLFTTLLMcfKPCYRYHPQPAAYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.10|      40|      54|    1796|    1841|      11
---------------------------------------------------------------------------
 1796- 1841 (52.85/66.97)	RRLALHRNTLgkKQIIEVRASVEASIDFGddvEFQWEDIRVaMSSI
 1853- 1892 (66.25/55.36)	KRGALINEGL..RIVILGQTNVGKSSLFN...HMANRDMAI.VSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.00|      34|      38|     549|     582|      12
---------------------------------------------------------------------------
  549-  582 (58.99/36.49)	KKTPLPLSLIDSLTFHARNHLFQLCLLKLTAMLS
  587-  619 (50.70/30.30)	QKVPSP.ATIDTLVRLAVTTEFEYGVKQVLALLS
  627-  647 (27.31/12.83)	KSTNLGPAQQD....RSRDLLFVLC.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.55|      20|      38|    1285|    1304|      13
---------------------------------------------------------------------------
 1285- 1304 (34.66/23.18)	LLTENQLLTNLALGHAYLQH
 1325- 1344 (32.89/21.58)	LVTEAQLIFVLRLVVPILQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.43|      18|      44|      74|      91|      16
---------------------------------------------------------------------------
   74-   91 (32.94/17.23)	QCCK.....ASLSLLSNKDDPRY
  115-  137 (28.49/13.98)	DCCEllilcTNFSLTTPMDSRKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05091 with Med23 domain of Kingdom Metazoa
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