<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05089

Description Uncharacterized protein
SequenceMERCSFILKKKNRKCRMLVKNGQKYCGEHAIYDDQNEDRIICPNDPRHTVNKSHLQKHLSSRCNSRLPEVPWIVKNFNLAGSPNGVEPWYRPSDGEFLRIRKIIERIYNQIASDITDSFLKNEFIENCASSFSKLKKKHIWQISSIIEHLRIIELLNNDKRWCMIDFGTGRAQLSYWMAKIAPKCRFLLIEKMGSRNKFDNKIHKFKLIHFKIEELDLVFLERLRCSVEHLDLSKIDLIRDVDNTAAVCKHFCGAATDFGIRCLMNGVKSGLNVNGFVLAPCCHHRTTYNEYIGRAFLGSHGICSSDEFAALRHISTWAVCGFLNQENLDATVSVSSHSPKFENLGQQKAKLEFMLLNSAEKELLGQKAKAVLEFGRVVELRKFGYDVSLCRYVKRTVSPENLLIDNSDSPKVDGMSIEGSGLNSVSGPETSEEQKKRFEIECEFVQALANPHYLNSQRGYFKEPYFINYLKYLLYWKRPEYARALKYPQCLHFLEAVQSSAFREAITCTANAKFIEEQQLLQWQYYTRKRQRLHSFVTVAEPAVDLPSTCESCVLFAREFQEQLGNDRAVKISAVEKEFKFVEALEETCERMLQYKLHKEKSDISRFAKEESNTMKALNELRSKGVKVELGIPYEMWDTPSVEIVTLKQNCETLLERYENDLEQWYNIRNRPLLEEYLCKKRVLKRTERDCMEISDNLEL
Length701
PositionMiddle
OrganismBrugia pahangi (Filarial nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Spiruromorpha> Filarioidea> Onchocercidae> Brugia.
Aromaticity0.10
Grand average of hydropathy-0.457
Instability index44.10
Isoelectric point8.52
Molecular weight81562.83
Publications









Function






Annotated function

tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro)
and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
metal ion binding	GO:0046872	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
tRNA 2'-O-methyltransferase activity	GO:0106050	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05089
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.33|      16|      18|     339|     354|       2
---------------------------------------------------------------------------
  339-  354 (30.10/22.97)	SPKFENLGQQ.KAKLEF
  359-  375 (23.23/16.00)	SAEKELLGQKaKAVLEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.24|      16|      18|     482|     499|       3
---------------------------------------------------------------------------
  445-  457 (20.72/ 6.15)	FVQALANP...HYLNS
  482-  497 (28.25/12.45)	YARALKYPQCLHFLEA
  503-  518 (21.27/ 9.20)	FREAITCTANAKFIEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.54|      21|     169|       5|      25|       4
---------------------------------------------------------------------------
    5-   25 (38.60/25.64)	SFILKKKNRKCRMLV..KNG..QKY
  175-  199 (31.94/19.98)	SYWMAKIAPKCRFLLieKMGsrNKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05089 with Med31 domain of Kingdom Metazoa
Unable to open file!