<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05086

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMLRPAQERETLWHGICIRSYTYRSLVLGFGVAQRATCVLQWAAGAHRYTVATPAHQPAANAHHLLHHHLDNYINWHKDLMSFGVVLRETYAPLLALSRLPTLPQLGLHHVRTQMPTPTFTLLAHSWRKIRIIYAGAYSLEVGIRGGNMVTIRDGSYSKFDRTTVVDEFAPALGPQVSSSTTSGSRGGGVRGGAGSAAAPLTVAKLELLCTPSEPPPGAPPGPPLAPLQRFLACVYLKRTLPRFIQQEEFLSLVCMEATSVTFRCESAGLSARVALHPQHMQSLHLQLSVLPEHKEILSPDDLQVMEKFFETRVAIPPYRSSALHGWARAFGAPPVALPSLAALMRADLAPAALAASAPAPPLWQLQWALRIPPAAPQIVPAGHPAVLNAKNKILFFICLTRGDTQLVLPLVYDSQNNSTQLADKRDAQPHLLAVNLHLKRFSEFNQTHSECTLWPAVRDLLTNFTLPQEAPPATAQPPP
Length479
PositionTail
OrganismPapilio machaon (Old World swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.08
Grand average of hydropathy-0.023
Instability index53.04
Isoelectric point9.30
Molecular weight52406.97
Publications
PubMed=26354079

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05086
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.70|      29|      45|     400|     429|       1
---------------------------------------------------------------------------
  400-  429 (47.32/28.01)	TRGDTQLvLPLVYDSQNNST..QLADKRDAQP
  447-  477 (50.37/26.19)	THSECTL.WPAVRDLLTNFTlpQEAPPATAQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.90|      22|      50|       3|      36|       2
---------------------------------------------------------------------------
    3-   25 (39.00/38.48)	RPAQERETL..........WH......GICIRSyTYRSL
   56-   93 (28.90/ 7.80)	QPAANAHHLlhhhldnyinWHkdlmsfGVVLRE.TYAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.70|      19|      19|     334|     352|       3
---------------------------------------------------------------------------
  195-  217 (27.43/11.02)	SAAAPltvaKLELLCTPSEPPPG
  334-  352 (29.79/12.66)	PVALP....SLAALMRADLAPAA
  356-  374 (37.48/18.01)	SAPAP....PLWQLQWALRIPPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.62|      16|      16|     228|     243|       5
---------------------------------------------------------------------------
  228-  243 (29.18/19.16)	QRFLACVYLKRTLPRF
  247-  262 (27.44/17.62)	EEFLSLVCMEATSVTF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05086 with Med14 domain of Kingdom Metazoa
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