<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05083
Description |
RNA polymerase II holoenzyme cyclin-like subunit |
Sequence | MAANYWESSQHQNWLFTRASLADIRDDLDNSYKTLVTQHPYPDRRLMFIFLRDRILQMVKRLPFRQQCVATALVYMHRFLLSTPMQNVNIYLLVATAFYLASKTEESPHHIRVVAAEARNSWPDFIPGDVSRLGEMEFCLISEMRSQLIVWHPYRTLIDLKDNQNLKLTSDELGLAWCIINDSYMTDLPLTCPPFLIAVIAMFLAVVFYPYSKNSGNRQADLHSAVNLDGPFATMGSRPGMAGLMSSAMHALPMNPPISAASASANGANGRASAAGKDPLPMITPDRQQTLATIASSEKLTNTIKFLVESEIDLKQMINGTQEIISLYSVWEEYHEKSIKEAIARCFKSNYFDS |
Length | 354 |
Position | Kinase |
Organism | Phialophora attae |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Phialophora.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.109 |
Instability index | 42.28 |
Isoelectric point | 6.31 |
Molecular weight | 39985.53 |
Publications | |
Function
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The SRB8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II.
Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The srb8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II.
ECO:0000256 ARBA:ARBA00002306
ECO:0000256 ARBA:ARBA00003882
|
GO - Cellular Component | integral component of membrane GO:0016021 IEA:UniProtKB-KW
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP05083
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 112.50| 32| 151| 10| 41| 1
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10- 41 (58.46/38.69) QHQNWLFTRASLADIRDDLDNSYKT..LVTQHPY
162- 195 (54.04/35.26) DNQNLKLTSDELGLAWCIINDSYMTdlPLTCPPF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 99.26| 32| 224| 56| 89| 2
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56- 89 (54.54/55.40) LQMVkrLPFRQQCVAT.....ALVYMHRFLLSTPM...QNVN
280- 319 (44.72/37.19) LPMI..TPDRQQTLATiasseKLTNTIKFLVESEIdlkQMIN
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