<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05083

Description RNA polymerase II holoenzyme cyclin-like subunit
SequenceMAANYWESSQHQNWLFTRASLADIRDDLDNSYKTLVTQHPYPDRRLMFIFLRDRILQMVKRLPFRQQCVATALVYMHRFLLSTPMQNVNIYLLVATAFYLASKTEESPHHIRVVAAEARNSWPDFIPGDVSRLGEMEFCLISEMRSQLIVWHPYRTLIDLKDNQNLKLTSDELGLAWCIINDSYMTDLPLTCPPFLIAVIAMFLAVVFYPYSKNSGNRQADLHSAVNLDGPFATMGSRPGMAGLMSSAMHALPMNPPISAASASANGANGRASAAGKDPLPMITPDRQQTLATIASSEKLTNTIKFLVESEIDLKQMINGTQEIISLYSVWEEYHEKSIKEAIARCFKSNYFDS
Length354
PositionKinase
OrganismPhialophora attae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Phialophora.
Aromaticity0.10
Grand average of hydropathy-0.109
Instability index42.28
Isoelectric point6.31
Molecular weight39985.53
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The SRB8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II. 

Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The srb8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05083
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.50|      32|     151|      10|      41|       1
---------------------------------------------------------------------------
   10-   41 (58.46/38.69)	QHQNWLFTRASLADIRDDLDNSYKT..LVTQHPY
  162-  195 (54.04/35.26)	DNQNLKLTSDELGLAWCIINDSYMTdlPLTCPPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.26|      32|     224|      56|      89|       2
---------------------------------------------------------------------------
   56-   89 (54.54/55.40)	LQMVkrLPFRQQCVAT.....ALVYMHRFLLSTPM...QNVN
  280-  319 (44.72/37.19)	LPMI..TPDRQQTLATiasseKLTNTIKFLVESEIdlkQMIN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05083 with CycC domain of Kingdom Fungi
Unable to open file!