<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05083

Description RNA polymerase II holoenzyme cyclin-like subunit
SequenceMAANYWESSQHQNWLFTRASLADIRDDLDNSYKTLVTQHPYPDRRLMFIFLRDRILQMVKRLPFRQQCVATALVYMHRFLLSTPMQNVNIYLLVATAFYLASKTEESPHHIRVVAAEARNSWPDFIPGDVSRLGEMEFCLISEMRSQLIVWHPYRTLIDLKDNQNLKLTSDELGLAWCIINDSYMTDLPLTCPPFLIAVIAMFLAVVFYPYSKNSGNRQADLHSAVNLDGPFATMGSRPGMAGLMSSAMHALPMNPPISAASASANGANGRASAAGKDPLPMITPDRQQTLATIASSEKLTNTIKFLVESEIDLKQMINGTQEIISLYSVWEEYHEKSIKEAIARCFKSNYFDS
Length354
PositionKinase
OrganismPhialophora attae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Phialophora.
Aromaticity0.10
Grand average of hydropathy-0.109
Instability index42.28
Isoelectric point6.31
Molecular weight39985.53
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The SRB8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II. 

Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The srb8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II. 


ECO:0000256	ARBA:ARBA00002306
ECO:0000256	ARBA:ARBA00003882

GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP05083
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.50|      32|     151|      10|      41|       1
---------------------------------------------------------------------------
   10-   41 (58.46/38.69)	QHQNWLFTRASLADIRDDLDNSYKT..LVTQHPY
  162-  195 (54.04/35.26)	DNQNLKLTSDELGLAWCIINDSYMTdlPLTCPPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.26|      32|     224|      56|      89|       2
---------------------------------------------------------------------------
   56-   89 (54.54/55.40)	LQMVkrLPFRQQCVAT.....ALVYMHRFLLSTPM...QNVN
  280-  319 (44.72/37.19)	LPMI..TPDRQQTLATiasseKLTNTIKFLVESEIdlkQMIN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05083 with CycC domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA